Skip to main content

Main menu

  • HOME
  • CONTENT
    • Early Release
    • Featured
    • Current Issue
    • Issue Archive
    • Blog
    • Collections
    • Podcast
  • TOPICS
    • Cognition and Behavior
    • Development
    • Disorders of the Nervous System
    • History, Teaching and Public Awareness
    • Integrative Systems
    • Neuronal Excitability
    • Novel Tools and Methods
    • Sensory and Motor Systems
  • ALERTS
  • FOR AUTHORS
  • ABOUT
    • Overview
    • Editorial Board
    • For the Media
    • Privacy Policy
    • Contact Us
    • Feedback
  • SUBMIT

User menu

Search

  • Advanced search
eNeuro
eNeuro

Advanced Search

 

  • HOME
  • CONTENT
    • Early Release
    • Featured
    • Current Issue
    • Issue Archive
    • Blog
    • Collections
    • Podcast
  • TOPICS
    • Cognition and Behavior
    • Development
    • Disorders of the Nervous System
    • History, Teaching and Public Awareness
    • Integrative Systems
    • Neuronal Excitability
    • Novel Tools and Methods
    • Sensory and Motor Systems
  • ALERTS
  • FOR AUTHORS
  • ABOUT
    • Overview
    • Editorial Board
    • For the Media
    • Privacy Policy
    • Contact Us
    • Feedback
  • SUBMIT
PreviousNext
Research ArticleResearch Article: New Research, Disorders of the Nervous System

Differential Electrographic Signatures Generated by Mechanistically-Diverse Seizurogenic Compounds in the Larval Zebrafish Brain

Joseph Pinion, Callum Walsh, Marc Goodfellow, Andrew D. Randall, Charles R. Tyler and Matthew J. Winter
eNeuro 28 February 2022, 9 (2) ENEURO.0337-21.2022; https://doi.org/10.1523/ENEURO.0337-21.2022
Joseph Pinion
1Biosciences, College of Life and Environmental Sciences, University of Exeter, Exeter, Devon EX4 4QD, United Kingdom
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Callum Walsh
2Medical School, University of Exeter, Exeter, Devon EX4 4PS, United Kingdom
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Marc Goodfellow
3Living Systems Institute and Mathematics, College of Engineering, Mathematics and Physical Sciences, University of Exeter, Exeter, Devon EX4 4QF, United Kingdom
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Andrew D. Randall
2Medical School, University of Exeter, Exeter, Devon EX4 4PS, United Kingdom
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Charles R. Tyler
1Biosciences, College of Life and Environmental Sciences, University of Exeter, Exeter, Devon EX4 4QD, United Kingdom
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Matthew J. Winter
1Biosciences, College of Life and Environmental Sciences, University of Exeter, Exeter, Devon EX4 4QD, United Kingdom
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF
Loading

Article Information

DOI 
https://doi.org/10.1523/ENEURO.0337-21.2022
PubMed 
35228313
Published By 
Society for Neuroscience
History 
  • Received August 16, 2021
  • Revision received January 13, 2022
  • Accepted January 21, 2022
  • Published online February 28, 2022.
Copyright & Usage 
Copyright © 2022 Pinion et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Joseph Pinion1,
  2. Callum Walsh2,
  3. Marc Goodfellow3,
  4. Andrew D. Randall2,
  5. Charles R. Tyler1 and
  6. Matthew J. Winter1
  1. 1Biosciences, College of Life and Environmental Sciences, University of Exeter, Exeter, Devon EX4 4QD, United Kingdom
  2. 2Medical School, University of Exeter, Exeter, Devon EX4 4PS, United Kingdom
  3. 3Living Systems Institute and Mathematics, College of Engineering, Mathematics and Physical Sciences, University of Exeter, Exeter, Devon EX4 4QF, United Kingdom
  1. Correspondence should be addressed to Matthew J. Winter at M.Winter{at}exeter.ac.uk.
View Full Text

Author contributions

  1. Author contributions: A.D.R., C.R.T., and M.J.W. designed research; J.P. performed research; J.P., C.W., and M.G. analyzed data; J.P. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by the National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) through a Ph.D. Studentship awarded to J.P. (NC/R001421/1) and by the University of Exeter, College of Life and Environmental Sciences.

Funding

  • National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs)

    NC/R001421/1

Other Version

  • You are viewing the most recent version of this article.
  • previous version (February 28, 2022).

Online Impact

 

Article usage

Select a custom date range for the past year
E.g., 2025-12-13
to
E.g., 2025-12-13

Article usage: February 2022 to December 2025

AbstractFullPdf
Feb 20221508
Mar 202240147164
Apr 202271229140
May 20223113033
Jun 20221610821
Jul 202278019
Aug 202286913
Sep 202258122
Oct 2022138023
Nov 202266317
Dec 202255014
Total 2022578937474
Jan 202335513
Feb 202337111
Mar 202337912
Apr 20232793
May 202368040
Jun 20232807
Jul 202368615
Aug 202338127
Sep 202357921
Oct 202348611
Nov 202378513
Dec 2023210112
Total 202346962185
Jan 20244785
Feb 202448016
Mar 202418610
Apr 202477517
May 202469319
Jun 20246877
Jul 2024109425
Aug 202478412
Sep 202487726
Oct 202427912
Nov 202467712
Dec 202468413
Total 202467994174
Jan 202569715
Feb 202511089
Mar 2025510414
Apr 202528313
May 202529410
Jun 202579714
Jul 20251410232
Aug 202529119
Sep 2025814422
Oct 202599913
Nov 2025812116
Dec 20253292
Total 2025671169179
Total75840621012
Back to top

In this issue

eneuro: 9 (2)
eNeuro
Vol. 9, Issue 2
March/April 2022
  • Table of Contents
  • Index by author
  • Ed Board (PDF)
Email

Thank you for sharing this eNeuro article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Differential Electrographic Signatures Generated by Mechanistically-Diverse Seizurogenic Compounds in the Larval Zebrafish Brain
(Your Name) has forwarded a page to you from eNeuro
(Your Name) thought you would be interested in this article in eNeuro.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Print
View Full Page PDF
Citation Tools
Differential Electrographic Signatures Generated by Mechanistically-Diverse Seizurogenic Compounds in the Larval Zebrafish Brain
Joseph Pinion, Callum Walsh, Marc Goodfellow, Andrew D. Randall, Charles R. Tyler, Matthew J. Winter
eNeuro 28 February 2022, 9 (2) ENEURO.0337-21.2022; DOI: 10.1523/ENEURO.0337-21.2022

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Respond to this article
Share
Differential Electrographic Signatures Generated by Mechanistically-Diverse Seizurogenic Compounds in the Larval Zebrafish Brain
Joseph Pinion, Callum Walsh, Marc Goodfellow, Andrew D. Randall, Charles R. Tyler, Matthew J. Winter
eNeuro 28 February 2022, 9 (2) ENEURO.0337-21.2022; DOI: 10.1523/ENEURO.0337-21.2022
Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Significance Statement
    • Introduction
    • Materials and Methods
    • Results
    • Discussion
    • Acknowledgments
    • Footnotes
    • References
    • Synthesis
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF

Keywords

  • 3Rs
  • drug discovery
  • electrophysiology
  • neuropharmacology
  • seizures
  • zebrafish

Responses to this article

Respond to this article

Jump to comment:

No eLetters have been published for this article.

Related Articles

Cited By...

More in this TOC Section

Research Article: New Research

  • Anxiety-associated behaviors following ablation of Miro1 from cortical excitatory neurons
  • Different but complementary motor functions reveal an asymmetric recalibration of upper limb bimanual coordination
  • Altered excitability and glutamatergic synaptic transmission in the medium spiny neurons of the nucleus accumbens in mice deficient in the heparan sulfate endosulfatase Sulf1
Show more Research Article: New Research

Disorders of the Nervous System

  • Altered PI3K/mTOR signaling within the forebrain leads to respiratory deficits in a mouse model of epilepsy
  • Lack of ADAP1/Centaurin-α1 Ameliorates Cognitive Impairment and Neuropathological Hallmarks in a Mouse Model of Alzheimer's Disease
  • The PDGFBB-PDGFRβ Pathway and Laminins in Pericytes Are Involved in the Temporal Change of AQP4 Polarity during Temporal Lobe Epilepsy Pathogenesis
Show more Disorders of the Nervous System

Subjects

  • Disorders of the Nervous System
  • Home
  • Alerts
  • Follow SFN on BlueSky
  • Visit Society for Neuroscience on Facebook
  • Follow Society for Neuroscience on Twitter
  • Follow Society for Neuroscience on LinkedIn
  • Visit Society for Neuroscience on Youtube
  • Follow our RSS feeds

Content

  • Early Release
  • Current Issue
  • Latest Articles
  • Issue Archive
  • Blog
  • Browse by Topic

Information

  • For Authors
  • For the Media

About

  • About the Journal
  • Editorial Board
  • Privacy Notice
  • Contact
  • Feedback
(eNeuro logo)
(SfN logo)

Copyright © 2025 by the Society for Neuroscience.
eNeuro eISSN: 2373-2822

The ideas and opinions expressed in eNeuro do not necessarily reflect those of SfN or the eNeuro Editorial Board. Publication of an advertisement or other product mention in eNeuro should not be construed as an endorsement of the manufacturer’s claims. SfN does not assume any responsibility for any injury and/or damage to persons or property arising from or related to any use of any material contained in eNeuro.