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Research ArticleResearch Article: New Research, Neuronal Excitability

Prenatal Opioid Exposure Impairs Endocannabinoid and Glutamate Transmission in the Dorsal Striatum

Gregory G. Grecco, Braulio Muñoz, Gonzalo Viana Di Prisco, Emma H. Doud, Brandon M. Fritz, Danielle Maulucci, Yong Gao, Amber L. Mosley, Anthony J. Baucum and Brady K. Atwood
eNeuro 8 April 2022, 9 (2) ENEURO.0119-22.2022; https://doi.org/10.1523/ENEURO.0119-22.2022
Gregory G. Grecco
1Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, Indiana 46202
2Medical Scientist Training Program, Indiana University School of Medicine, Indianapolis, Indiana 46202
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  • ORCID record for Gregory G. Grecco
Braulio Muñoz
1Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, Indiana 46202
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Gonzalo Viana Di Prisco
1Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, Indiana 46202
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Emma H. Doud
3Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202
4Center for Proteome Analysis, Indiana University School of Medicine, Indianapolis, Indiana 46202
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Brandon M. Fritz
1Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, Indiana 46202
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Danielle Maulucci
1Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, Indiana 46202
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Yong Gao
1Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, Indiana 46202
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Amber L. Mosley
3Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202
4Center for Proteome Analysis, Indiana University School of Medicine, Indianapolis, Indiana 46202
5Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, Indiana 46202
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Anthony J. Baucum
1Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, Indiana 46202
6Department of Biology, Indiana University-Purdue University, Indianapolis, Indiana 46202
7Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, Indiana 46202
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Brady K. Atwood
1Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, Indiana 46202
7Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, Indiana 46202
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0119-22.2022
PubMed 
35396255
Published By 
Society for Neuroscience
History 
  • Received March 20, 2022
  • Accepted March 24, 2022
  • Published online April 8, 2022.
Copyright & Usage 
Copyright © 2022 Grecco et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Gregory G. Grecco1,2,
  2. Braulio Muñoz1,
  3. Gonzalo Viana Di Prisco1,
  4. Emma H. Doud3,4,
  5. Brandon M. Fritz1,
  6. Danielle Maulucci1,
  7. Yong Gao1,
  8. Amber L. Mosley3,4,5,
  9. Anthony J. Baucum1,6,7 and
  10. Brady K. Atwood1,7
  1. 1Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, Indiana 46202
  2. 2Medical Scientist Training Program, Indiana University School of Medicine, Indianapolis, Indiana 46202
  3. 3Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202
  4. 4Center for Proteome Analysis, Indiana University School of Medicine, Indianapolis, Indiana 46202
  5. 5Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, Indiana 46202
  6. 6Department of Biology, Indiana University-Purdue University, Indianapolis, Indiana 46202
  7. 7Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, Indiana 46202
  1. Correspondence should be addressed to Brady K. Atwood at bkatwood{at}iu.edu.
View Full Text

Author contributions

  1. Author contributions: G.G.G. and B.K.A. designed research; G.G.G., B.M., G.V.D.P., E.H.D., B.M.F., D.M., and Y.G. performed research; G.G.G., B.M., G.V.D.P., E.H.D., B.M.F., A.L.M., and A.J.B. analyzed data; G.G.G. and B.K.A. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • The proteomics work was supported, in part, by the Indiana Clinical and Translational Sciences Institute and, in part, by Grant UL1-TR-002529 from the National Institutes of Health (NIH), the National Center for Advancing Translational Sciences, a Clinical and Translational Sciences Award, and Cancer Center Support Grant P30-CA-082709 for the Indiana University Simon Comprehensive Cancer Center from the National Cancer Institute. This work was also supported by NIH grants R01-AA-027214 (to B.K.A.), F30-AA-028687 (to G.G.G.), and F32-AA-026488 (to B.M.F.); by Indiana University (B.K.A.); Indiana University Health (B.K.A.), and the Stark Neurosciences Research Institute (B.K.A., G.G.G.).

Funding

  • Indiana CTSI

    UL1TR002529
  • HHS | NIH | National Cancer Institute (NCI)

    P30CA082709
  • National Institute on Alcohol Abuse and Alcoholism

    R01AA027214; F30AA028687; F32AA026488

Other Version

  • You are viewing the most recent version of this article.
  • previous version (April 08, 2022).

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Prenatal Opioid Exposure Impairs Endocannabinoid and Glutamate Transmission in the Dorsal Striatum
Gregory G. Grecco, Braulio Muñoz, Gonzalo Viana Di Prisco, Emma H. Doud, Brandon M. Fritz, Danielle Maulucci, Yong Gao, Amber L. Mosley, Anthony J. Baucum, Brady K. Atwood
eNeuro 8 April 2022, 9 (2) ENEURO.0119-22.2022; DOI: 10.1523/ENEURO.0119-22.2022

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Prenatal Opioid Exposure Impairs Endocannabinoid and Glutamate Transmission in the Dorsal Striatum
Gregory G. Grecco, Braulio Muñoz, Gonzalo Viana Di Prisco, Emma H. Doud, Brandon M. Fritz, Danielle Maulucci, Yong Gao, Amber L. Mosley, Anthony J. Baucum, Brady K. Atwood
eNeuro 8 April 2022, 9 (2) ENEURO.0119-22.2022; DOI: 10.1523/ENEURO.0119-22.2022
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Keywords

  • endocannabinoid
  • methadone
  • plasticity
  • prenatal opioid exposure
  • proteomics

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