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Research ArticleResearch Article: New Research, Disorders of the Nervous System

Impaired Subcortical Processing of Amplitude-Modulated Tones in Mice Deficient for Cacna2d3, a Risk Gene for Autism Spectrum Disorders in Humans

Gerhard Bracic, Katrin Hegmann, Jutta Engel and Simone Kurt
eNeuro 11 April 2022, 9 (2) ENEURO.0118-22.2022; DOI: https://doi.org/10.1523/ENEURO.0118-22.2022
Gerhard Bracic
1School of Medicine, Department of Biophysics, Center for Integrative Physiology and Molecular Medicine (CIPMM), Saarland University, Homburg 66421, Germany
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Katrin Hegmann
2Institute of Neurobiology, University of Ulm, Ulm 89069, Germany
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Jutta Engel
1School of Medicine, Department of Biophysics, Center for Integrative Physiology and Molecular Medicine (CIPMM), Saarland University, Homburg 66421, Germany
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Simone Kurt
1School of Medicine, Department of Biophysics, Center for Integrative Physiology and Molecular Medicine (CIPMM), Saarland University, Homburg 66421, Germany
2Institute of Neurobiology, University of Ulm, Ulm 89069, Germany
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0118-22.2022
PubMed 
35410870
Published By 
Society for Neuroscience
History 
  • Received March 19, 2022
  • Accepted March 21, 2022
  • Published online April 11, 2022.
Copyright & Usage 
Copyright © 2022 Bracic et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Gerhard Bracic1,
  2. Katrin Hegmann2,
  3. Jutta Engel1 and
  4. Simone Kurt1,2
  1. 1School of Medicine, Department of Biophysics, Center for Integrative Physiology and Molecular Medicine (CIPMM), Saarland University, Homburg 66421, Germany
  2. 2Institute of Neurobiology, University of Ulm, Ulm 89069, Germany
  1. Correspondence should be addressed to Simone Kurt at simone.kurt{at}uni-saarland.de.
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Author contributions

  1. Author contributions: S.K. designed research; K.H. and S.K. performed research; G.B., K.H., and S.K. analyzed data; G.B., J.E., and S.K. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by Deutsche Forschungsgemeinschaft (DFG) Grant PP1608 (En 294/5-1, En 294/5-2, and KU 1972/5-2) and CRC 894 (to J.E.).

Funding

  • DFG PP1608

    En 294/5-1; En 294/5-2; KU 1972/5-2

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Impaired Subcortical Processing of Amplitude-Modulated Tones in Mice Deficient for Cacna2d3, a Risk Gene for Autism Spectrum Disorders in Humans
Gerhard Bracic, Katrin Hegmann, Jutta Engel, Simone Kurt
eNeuro 11 April 2022, 9 (2) ENEURO.0118-22.2022; DOI: 10.1523/ENEURO.0118-22.2022

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Impaired Subcortical Processing of Amplitude-Modulated Tones in Mice Deficient for Cacna2d3, a Risk Gene for Autism Spectrum Disorders in Humans
Gerhard Bracic, Katrin Hegmann, Jutta Engel, Simone Kurt
eNeuro 11 April 2022, 9 (2) ENEURO.0118-22.2022; DOI: 10.1523/ENEURO.0118-22.2022
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Keywords

  • auditory processing disorder
  • autism spectrum disorders
  • Ca2+ channel subunit
  • Cacna2d3
  • inferior colliculus
  • temporal coding

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