Skip to main content

Main menu

  • HOME
  • CONTENT
    • Early Release
    • Featured
    • Current Issue
    • Issue Archive
    • Blog
    • Collections
    • Podcast
  • TOPICS
    • Cognition and Behavior
    • Development
    • Disorders of the Nervous System
    • History, Teaching and Public Awareness
    • Integrative Systems
    • Neuronal Excitability
    • Novel Tools and Methods
    • Sensory and Motor Systems
  • ALERTS
  • FOR AUTHORS
  • ABOUT
    • Overview
    • Editorial Board
    • For the Media
    • Privacy Policy
    • Contact Us
    • Feedback
  • SUBMIT

User menu

Search

  • Advanced search
eNeuro
eNeuro

Advanced Search

 

  • HOME
  • CONTENT
    • Early Release
    • Featured
    • Current Issue
    • Issue Archive
    • Blog
    • Collections
    • Podcast
  • TOPICS
    • Cognition and Behavior
    • Development
    • Disorders of the Nervous System
    • History, Teaching and Public Awareness
    • Integrative Systems
    • Neuronal Excitability
    • Novel Tools and Methods
    • Sensory and Motor Systems
  • ALERTS
  • FOR AUTHORS
  • ABOUT
    • Overview
    • Editorial Board
    • For the Media
    • Privacy Policy
    • Contact Us
    • Feedback
  • SUBMIT
PreviousNext
Research ArticleResearch Article: New Research, Disorders of the Nervous System

Disruption of VGLUT1 in Cholinergic Medial Habenula Projections Increases Nicotine Self-Administration

Elizabeth A. Souter, Yen-Chu Chen, Vivien Zell, Valeria Lallai, Thomas Steinkellner, William S. Conrad, William Wisden, Kenneth D. Harris, Christie D. Fowler and Thomas S. Hnasko
eNeuro 7 December 2021, 9 (1) ENEURO.0481-21.2021; https://doi.org/10.1523/ENEURO.0481-21.2021
Elizabeth A. Souter
1Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Elizabeth A. Souter
Yen-Chu Chen
2Department of Neurobiology and Behavior sciences, University of California, Irvine, Irvine, CA 92697
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Vivien Zell
1Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Valeria Lallai
2Department of Neurobiology and Behavior sciences, University of California, Irvine, Irvine, CA 92697
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Valeria Lallai
Thomas Steinkellner
1Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
William S. Conrad
1Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
William Wisden
3Department of Life Sciences and UK Dementia Research Institute, Imperial College London, London SW7 2AZ, United Kingdom
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for William Wisden
Kenneth D. Harris
4Institute of Neurology, University College London, London WC1N 3BG, United Kingdom
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Kenneth D. Harris
Christie D. Fowler
2Department of Neurobiology and Behavior sciences, University of California, Irvine, Irvine, CA 92697
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Christie D. Fowler
Thomas S. Hnasko
1Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093
5Research Service VA San Diego Healthcare System, San Diego, CA 92161
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Thomas S. Hnasko
  • Article
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF
Loading

Article Information

DOI 
https://doi.org/10.1523/ENEURO.0481-21.2021
PubMed 
34876472
Published By 
Society for Neuroscience
History 
  • Received November 12, 2021
  • Accepted November 21, 2021
  • Published online December 7, 2021.
Copyright & Usage 
Copyright © 2022 Souter et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Elizabeth A. Souter1,
  2. Yen-Chu Chen2,
  3. Vivien Zell1,
  4. Valeria Lallai2,
  5. Thomas Steinkellner1,
  6. William S. Conrad1,
  7. William Wisden3,
  8. Kenneth D. Harris4,
  9. Christie D. Fowler2 and
  10. Thomas S. Hnasko1,5
  1. 1Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093
  2. 2Department of Neurobiology and Behavior sciences, University of California, Irvine, Irvine, CA 92697
  3. 3Department of Life Sciences and UK Dementia Research Institute, Imperial College London, London SW7 2AZ, United Kingdom
  4. 4Institute of Neurology, University College London, London WC1N 3BG, United Kingdom
  5. 5Research Service VA San Diego Healthcare System, San Diego, CA 92161
  1. Correspondence should be addressed to Thomas S. Hnasko at thnasko{at}health.ucsd.edu.
View Full Text

Author contributions

  1. Author contributions: T.S.H. designed research; E.A.S., Y.-C.C., V.Z., V.L., T.S., W.S.C., C.D.F., and T.S.H. performed research; W.W. and K.D.H. contributed unpublished reagents/analytic tools; E.A.S., Y.-C.C., V.Z., V.L., T.S., W.S.C., C.D.F., and T.S.H. analyzed data; E.A.S., W.S.C., C.D.F., and T.S.H. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by the Tobacco-Related Disease Research Program Grant 340144; and National Institutes of Health National Institute on Drug Abuse Grants R01DA036612, K99DA046514, and DP1DA039658, National Institute on Aging Grant K99AG059834, and National Institute on Deafness and Other Communication Disorders Grant R01DC009947-01.

Funding

  • Tobacco-Related Disease Research Program (TRDRP)

    340144
  • HHS | NIH | National Institute on Drug Abuse (NIDA)

    R01DA036612; K99DA046514; DP1DA039658
  • HHS | NIH | National Institute on Aging (NIA)

    K99AG059834
  • HHS | NIH | National Institute on Deafness and Other Communication Disorders (NIDCD)

    R01DC009947-01

Other Version

  • You are viewing the most recent version of this article.
  • previous version (December 07, 2021).

Online Impact

 

Article usage

Select a custom date range for the past year
E.g., 2025-06-16
to
E.g., 2025-06-16

Article usage: December 2021 to June 2025

AbstractFullPdf
Dec 20213800155
Total 20213800155
Jan 2022189360138
Feb 202253234111
Mar 20221816770
Apr 202288521
May 2022711625
Jun 2022311717
Jul 202248626
Aug 202218121
Sep 202257036
Oct 2022148225
Nov 2022219928
Dec 2022117618
Total 20223341573536
Jan 2023118523
Feb 202317815
Mar 202326915
Apr 202319213
May 202337722
Jun 2023110417
Jul 20231110836
Aug 202348347
Sep 2023711121
Oct 2023212228
Nov 202339020
Dec 20231012645
Total 2023561145302
Jan 2024212239
Feb 202449928
Mar 2024613045
Apr 20241111030
May 2024910424
Jun 2024610224
Jul 2024311337
Aug 2024910945
Sep 2024910031
Oct 2024310025
Nov 2024111025
Dec 20241011328
Total 2024731312381
Jan 2025811539
Feb 2025614127
Mar 2025912127
Apr 2025911026
May 2025611426
Jun 20254278
Total 202542628153
Total88546581527
Back to top

In this issue

eneuro: 9 (1)
eNeuro
Vol. 9, Issue 1
January/February 2022
  • Table of Contents
  • Index by author
  • Ed Board (PDF)
Email

Thank you for sharing this eNeuro article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Disruption of VGLUT1 in Cholinergic Medial Habenula Projections Increases Nicotine Self-Administration
(Your Name) has forwarded a page to you from eNeuro
(Your Name) thought you would be interested in this article in eNeuro.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Print
View Full Page PDF
Citation Tools
Disruption of VGLUT1 in Cholinergic Medial Habenula Projections Increases Nicotine Self-Administration
Elizabeth A. Souter, Yen-Chu Chen, Vivien Zell, Valeria Lallai, Thomas Steinkellner, William S. Conrad, William Wisden, Kenneth D. Harris, Christie D. Fowler, Thomas S. Hnasko
eNeuro 7 December 2021, 9 (1) ENEURO.0481-21.2021; DOI: 10.1523/ENEURO.0481-21.2021

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Respond to this article
Share
Disruption of VGLUT1 in Cholinergic Medial Habenula Projections Increases Nicotine Self-Administration
Elizabeth A. Souter, Yen-Chu Chen, Vivien Zell, Valeria Lallai, Thomas Steinkellner, William S. Conrad, William Wisden, Kenneth D. Harris, Christie D. Fowler, Thomas S. Hnasko
eNeuro 7 December 2021, 9 (1) ENEURO.0481-21.2021; DOI: 10.1523/ENEURO.0481-21.2021
Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Significance Statement
    • Introduction
    • Materials and Methods
    • Results
    • Discussion
    • Footnotes
    • References
    • Synthesis
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF

Keywords

  • Acetylcholine
  • corelease
  • glutamate
  • interpeduncular nucleus
  • medial habenula
  • nicotine

Responses to this article

Respond to this article

Jump to comment:

No eLetters have been published for this article.

Related Articles

Cited By...

More in this TOC Section

Research Article: New Research

  • Release of extracellular matrix components after human traumatic brain injury
  • Action intentions reactivate representations of task-relevant cognitive cues
  • Functional connectome correlates of laterality preferences: Insights into Hand, Foot, and Eye Dominance Across the Lifespan
Show more Research Article: New Research

Disorders of the Nervous System

  • Release of extracellular matrix components after human traumatic brain injury
  • Gene variants related to primary familial brain calcification: perspectives from bibliometrics and meta-analysis
  • Expression of HDAC3-Y298H Point Mutant in Medial Habenula Cholinergic Neurons Has No Effect on Cocaine-Induced Behaviors
Show more Disorders of the Nervous System

Subjects

  • Disorders of the Nervous System
  • Home
  • Alerts
  • Follow SFN on BlueSky
  • Visit Society for Neuroscience on Facebook
  • Follow Society for Neuroscience on Twitter
  • Follow Society for Neuroscience on LinkedIn
  • Visit Society for Neuroscience on Youtube
  • Follow our RSS feeds

Content

  • Early Release
  • Current Issue
  • Latest Articles
  • Issue Archive
  • Blog
  • Browse by Topic

Information

  • For Authors
  • For the Media

About

  • About the Journal
  • Editorial Board
  • Privacy Notice
  • Contact
  • Feedback
(eNeuro logo)
(SfN logo)

Copyright © 2025 by the Society for Neuroscience.
eNeuro eISSN: 2373-2822

The ideas and opinions expressed in eNeuro do not necessarily reflect those of SfN or the eNeuro Editorial Board. Publication of an advertisement or other product mention in eNeuro should not be construed as an endorsement of the manufacturer’s claims. SfN does not assume any responsibility for any injury and/or damage to persons or property arising from or related to any use of any material contained in eNeuro.