Article Figures & Data
Figures
- Figure 1.
Age-related changes in total GM volume (first row), total WM volume (second row), and total CSF volume (third row). The first column showed LME model estimates using all participants’ data, the second column using only that of male participants, and the third column for female participants. Dots correspond to raw volumes adjusted for sex and eTIV. Colored thin lines are conditional fit of the longitudinal data using the estimated LME model. Longer green thick lines represent association with baseline age, whereas shorter black thick lines represent association with time for the longitudinal component. Data from male participants are shown in blue, whereas that of female participants are shown in red. Estimated model parameters, t values, and p-values are given in Extended Data Figure 1-1.
- Figure 2.
Linear relationship between (a) regional GM volumes and baseline age as well as (b) regional GM volumes and time from baseline scan. The cortex is divided into 34 ROIs for each hemisphere based on the Desikan–Killany atlas. Estimated model parameters, t values, and p-values are given in Extended Data Figures 2-1, 2-2, 2-3 using data from all participants, male only, and female only, respectively.
- Figure 3.
Estimated LME models for selected subcortical ROIs using all participants’ data. Volumes are adjusted for sex and eTIV. Dots correspond to adjusted raw volumes. Colored thin lines are conditional fit of the longitudinal data using the estimated LME model. Longer green thick lines represent association with baseline age, whereas shorter black thick lines represent association with time for the longitudinal component. Data from male participants are shown in blue, whereas data from female participants are shown in red. Estimated model parameters, t values, and p-values are given in Extended Data Figure 3-1.
- Figure 4.
Estimates of LME model for cerebellar volumes: (a) cortex and (b) WM. Sex-specific LME estimates are also shown in the insets. Dots correspond to raw volumes adjusted for sex and eTIV. Colored thin lines are conditional fit of the longitudinal data using the estimated LME model. Longer green thick lines represent association with baseline age, whereas shorter black thick lines represent association with time for the longitudinal component. Data from male participants are shown in blue, whereas that of female participants are shown in red. Estimated model parameters, t values, and p-values are also given in Extended Data Figure 3-1.
Tables
Age group (M/F) All mean (SD) Male mean (SD) Female mean (SD) 50s (15/47) Age, years
Age range, years54.65 (3.07)
50.17–59.9254.38 (3.43)
50.17–59.9254.73 (2.98)
50.17–59.08MMSE 29.52 (0.67) 29.33 (0.82) 29.57 (0.62) ACE-R 97.42 (1.50) 97.13 (1.55) 97.51 (1.49) Education, years 14.03 (2.25) 15.00 (3.40) 13.72 (1.66) BDI 4.56 (5.33) 2.53 (2.50) 5.21 (5.83) 60s (24/59) Age, years
Age range, years65.21 (2.73)
60.17–69.9265.28 (2.59)
60.42–69.6765.18 (2.81)
60.17–69.92MMSE 29.43 (0.77) 29.50 (0.72) 29.41 (0.79) ACE-R 96.53 (2.46) 97.00 (2.62) 96.34 (2.39) Education, years 13.55 (2.09) 14.75 (2.27) 13.07 (1.82) BDI 4.18 (4.46)* 2.65 (3.31)* 4.78 (4.72) 70s (35/47) Age, years
Age range, years73.25 (2.64)
70.08–79.6773.42 (2.71)
70.42–79.6773.13 (2.60)
70.08–79.50MMSE 28.98 (1.02) 28.91 (1.09) 29.02 (0.97) ACE-R 94.70 (2.86) 94.34 (3.02) 94.96 (2.74) Education, years 13.17 (2.22) 14.31 (2.26) 12.32 (1.78) BDI 5.15 (4.62) 4.29 (4.09) 5.79 (4.92) ↵* One participant has no data.
M, male; F, female; MMSE, Mini-Mental State Examination total score; ACE-R, Addenbrooke’s Cognitive Examination–Revised total score; BDI - Beck Depression Inventory score.
Extended Data Figure 1-1
Estimated model parameters and their corresponding t values and p-values of the optimal LME models for the total GM volume, total WM volume, and total CSF volume using data from all participants, male only participants, and female only participants. Download Figure 1-1, XLS file.
Extended Data Figure 2-1
Estimated model parameters and their corresponding t values and p-values (corrected for multiple comparisons using FDR) of the optimal LME models for regional GM volume using all participants’ data. Download Figure 2-1, XLS file.
Extended Data Figure 2-2
Estimated model parameters and their corresponding t values and p-values (corrected for multiple comparisons using FDR) of the optimal LME models for regional GM volume using data from male participants only. Download Figure 2-2, XLS file.
Extended Data Figure 2-3
Estimated model parameters and their corresponding t values and p-values (corrected for multiple comparisons using FDR) of the optimal LME models for regional GM volume using data from female participants only. Download Figure 2-3, XLS file.
Extended Data Figure 3-1
Estimated model parameters and their corresponding t values and p-values (corrected for multiple comparisons using FDR) of the optimal LME models for selected subcortical ROIs using data from all participants, male only participants, and female only participants. This extended data supports both Figures 3, 4. Download Figure 3-1, XLS file.
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