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Research ArticleResearch Article: New Research, Disorders of the Nervous System

Metformin Reduces Repeat Mild Concussive Injury Pathophysiology

Erica L. Underwood, John B. Redell, Mark E. Maynard, Nobuhide Kobori, Michael J. Hylin, Kimberly N. Hood, Rebecca K. West, Jing Zhao, Anthony N. Moore and Pramod K. Dash
eNeuro 13 December 2021, 9 (1) ENEURO.0421-21.2021; DOI: https://doi.org/10.1523/ENEURO.0421-21.2021
Erica L. Underwood
Department of Neurobiology and Anatomy, The University of Texas McGovern Medical School, Houston, TX 77030
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John B. Redell
Department of Neurobiology and Anatomy, The University of Texas McGovern Medical School, Houston, TX 77030
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Mark E. Maynard
Department of Neurobiology and Anatomy, The University of Texas McGovern Medical School, Houston, TX 77030
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Nobuhide Kobori
Department of Neurobiology and Anatomy, The University of Texas McGovern Medical School, Houston, TX 77030
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Michael J. Hylin
Department of Neurobiology and Anatomy, The University of Texas McGovern Medical School, Houston, TX 77030
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Kimberly N. Hood
Department of Neurobiology and Anatomy, The University of Texas McGovern Medical School, Houston, TX 77030
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Rebecca K. West
Department of Neurobiology and Anatomy, The University of Texas McGovern Medical School, Houston, TX 77030
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Jing Zhao
Department of Neurobiology and Anatomy, The University of Texas McGovern Medical School, Houston, TX 77030
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Anthony N. Moore
Department of Neurobiology and Anatomy, The University of Texas McGovern Medical School, Houston, TX 77030
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Pramod K. Dash
Department of Neurobiology and Anatomy, The University of Texas McGovern Medical School, Houston, TX 77030
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0421-21.2021
PubMed 
34903525
Published By 
Society for Neuroscience
History 
  • Received October 6, 2021
  • Revision received November 5, 2021
  • Accepted November 9, 2021
  • Published online December 13, 2021.
Copyright & Usage 
Copyright © 2021 Underwood et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Erica L. Underwood*,
  2. John B. Redell*,
  3. Mark E. Maynard,
  4. Nobuhide Kobori,
  5. Michael J. Hylin,
  6. Kimberly N. Hood,
  7. Rebecca K. West,
  8. Jing Zhao,
  9. Anthony N. Moore and
  10. Pramod K. Dash
  1. Department of Neurobiology and Anatomy, The University of Texas McGovern Medical School, Houston, TX 77030
  1. Correspondence should be addressed to Pramod K. Dash at p.dash{at}uth.tmc.edu.
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Author contributions

  1. Author contributions: E.L.U., J.B.R., A.N.M., and P.K.D. designed research; E.L.U., J.B.R., M.E.M., N.K., M.J.H., K.N.H., J.Z., and A.N.M. performed research; E.L.U., J.B.R., M.E.M., N.K., M.J.H., K.N.H., A.N.M., and P.K.D. analyzed data; E.L.U., J.B.R., R.K.W., A.N.M., and P.K.D. wrote the paper.

  2. ↵* E.L.U. and J.B.R. contributed equally to this work.

  3. M. J. Hylin’s present address: Department of Psychology, Southern Illinois University, Carbondale, IL 62901.

  4. M. E. Maynard’s present address: Department of Electrical and Computer Engineering, University of Houston, Houston, TX 77204.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported in part by grants from the National Institutes of Health (NS086301, NS101686), and funds made available by the Gilson Longenbaugh Foundation/Mission Connect to P.K.D. Salary support for E.L.U. was provided by a T32 grant (2T32GM008792-16) from National Institute of General Medical Sciences.

Funding

  • HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS)

    NS086301; NS101686
  • HHS | NIH | National Institute of General Medical Sciences (NIGMS)

    2T32GM008792-16

Other Version

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Metformin Reduces Repeat Mild Concussive Injury Pathophysiology
Erica L. Underwood, John B. Redell, Mark E. Maynard, Nobuhide Kobori, Michael J. Hylin, Kimberly N. Hood, Rebecca K. West, Jing Zhao, Anthony N. Moore, Pramod K. Dash
eNeuro 13 December 2021, 9 (1) ENEURO.0421-21.2021; DOI: 10.1523/ENEURO.0421-21.2021

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Metformin Reduces Repeat Mild Concussive Injury Pathophysiology
Erica L. Underwood, John B. Redell, Mark E. Maynard, Nobuhide Kobori, Michael J. Hylin, Kimberly N. Hood, Rebecca K. West, Jing Zhao, Anthony N. Moore, Pramod K. Dash
eNeuro 13 December 2021, 9 (1) ENEURO.0421-21.2021; DOI: 10.1523/ENEURO.0421-21.2021
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Keywords

  • axonal injury
  • cognitive dysfunction
  • mild traumatic brain injury
  • oxygen consumption rate
  • repeat concussion
  • tissue respiration

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