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Research ArticleResearch Article: New Research, Cognition and Behavior

Oxytocin Facilitates Allomaternal Behavior under Stress in Laboratory Mice

Yousuke Tsuneoka, Chihiro Yoshihara, Ryuko Ohnishi, Sachine Yoshida, Eri Miyazawa, Masanobu Yamada, Kazuhiko Horiguchi, W. Scott Young, Katsuhiko Nishimori, Tadafumi Kato and Kumi O. Kuroda
eNeuro 11 January 2022, 9 (1) ENEURO.0405-21.2022; https://doi.org/10.1523/ENEURO.0405-21.2022
Yousuke Tsuneoka
1Laboratory for Affiliative Social Behavior, RIKEN Center for Brain Science, Wako 351-0198, Japan
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Chihiro Yoshihara
1Laboratory for Affiliative Social Behavior, RIKEN Center for Brain Science, Wako 351-0198, Japan
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Ryuko Ohnishi
1Laboratory for Affiliative Social Behavior, RIKEN Center for Brain Science, Wako 351-0198, Japan
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Sachine Yoshida
1Laboratory for Affiliative Social Behavior, RIKEN Center for Brain Science, Wako 351-0198, Japan
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Eri Miyazawa
1Laboratory for Affiliative Social Behavior, RIKEN Center for Brain Science, Wako 351-0198, Japan
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Masanobu Yamada
2Department of Internal Medicine, Division of Endocrinology and Metabolism, Gunma University Graduate School of Medicine, Maebashi 371-8511, Japan
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Kazuhiko Horiguchi
2Department of Internal Medicine, Division of Endocrinology and Metabolism, Gunma University Graduate School of Medicine, Maebashi 371-8511, Japan
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W. Scott Young
3Section on Neural Gene Expression, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892-9663
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Katsuhiko Nishimori
4Department of Obesity and Internal Inflammation, Fukushima Medical University, Fukushima 960-1295, Japan
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Tadafumi Kato
5Department of Psychiatry and Behavioral Science, Graduate School of Medicine, Juntendo University, Tokyo 113-0033, Japan
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Kumi O. Kuroda
1Laboratory for Affiliative Social Behavior, RIKEN Center for Brain Science, Wako 351-0198, Japan
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0405-21.2022
PubMed 
35017259
Published By 
Society for Neuroscience
History 
  • Received September 28, 2021
  • Revision received December 6, 2021
  • Accepted January 4, 2022
  • Published online January 11, 2022.
Copyright & Usage 
Copyright © 2022 Tsuneoka et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Yousuke Tsuneoka1,*,
  2. Chihiro Yoshihara1,*,
  3. Ryuko Ohnishi1,*,
  4. Sachine Yoshida1,*,
  5. Eri Miyazawa1,
  6. Masanobu Yamada2,
  7. Kazuhiko Horiguchi2,
  8. W. Scott Young3,
  9. Katsuhiko Nishimori4,
  10. Tadafumi Kato5 and
  11. Kumi O. Kuroda1
  1. 1Laboratory for Affiliative Social Behavior, RIKEN Center for Brain Science, Wako 351-0198, Japan
  2. 2Department of Internal Medicine, Division of Endocrinology and Metabolism, Gunma University Graduate School of Medicine, Maebashi 371-8511, Japan
  3. 3Section on Neural Gene Expression, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892-9663
  4. 4Department of Obesity and Internal Inflammation, Fukushima Medical University, Fukushima 960-1295, Japan
  5. 5Department of Psychiatry and Behavioral Science, Graduate School of Medicine, Juntendo University, Tokyo 113-0033, Japan
  1. Correspondence should be addressed to Kumi O. Kuroda at kumi.kuroda{at}riken.jp.
  • Y. Tsuneoka’s present address: Department of Anatomy, School of Medicine, Toho University, Tokyo 143-8540, Japan.

  • S. Yoshida’s present address: Department of Anatomy, School of Medicine, Toho University, Tokyo 143-8540, Japan.

  • R. Ohnishi’s present address: Department of Bioscience and Biotechnology, Faculty of Agriculture, University of the Ryukyus, Nishihara 903-0213, Japan.

View Full Text

Author contributions

  1. Author contributions: C.Y. and K.O.K. designed research; Y.T., C.Y., R.O., S.Y., and K.O.K. performed research; M.Y., K.H., W.S.Y., K.N., and T.K. contributed unpublished reagents/analytic tools; Y.T., C.Y., R.O., S.Y., E.M., and K.O.K. analyzed data; Y.T., C.Y., E.M., W.S.Y., T.K., and K.O.K. wrote the paper.

  2. ↵*Y.T., C.Y., R.O., and S.Y. contributed equally to this work.

  • Y. Tsuneoka’s present address: Department of Anatomy, School of Medicine, Toho University, Tokyo 143-8540, Japan.

  • S. Yoshida’s present address: Department of Anatomy, School of Medicine, Toho University, Tokyo 143-8540, Japan.

  • R. Ohnishi’s present address: Department of Bioscience and Biotechnology, Faculty of Agriculture, University of the Ryukyus, Nishihara 903-0213, Japan.

View Abstract

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported in part by the RIKEN Brain Science Institute (2004-2017), RIKEN Center for Brain Science (2018-21; K.O.K.), a Long-Term Fellowship of the Human Frontier Science Program (2002-2004; K.O.K.), a DRI Research Grant from RIKEN (2005-2006; K.O.K.), a Research Facilitation Grant of Uehara Memorial Foundation, Japan (2008; K.O.K.), and by Japan Society for the Promotion of Science KAKENHI Grant Numbers JP17790832, JP26282220, and JP18H02710 (to K.O.K.), JP21890307 (to Y.T.), and JP20890287 (to S.Y.). W.S.Y’s research was supported by the National Institutes of Health Intramural Research Program Grant ZIAMH002498.

Funding

  • Japan Society for the Promotion of Science (JSPS)

    JP17790832; JP26282220

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  • You are viewing the most recent version of this article.
  • previous version (January 11, 2022).

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AbstractFullPdf
Jan 20225170251
Feb 2022175102163
Mar 202240214126
Apr 20221511678
May 20221514746
Jun 20221813936
Jul 20221212441
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Sep 2022512147
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Total 20228681429938
Jan 2023129128
Feb 2023210426
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May 202318836
Jun 2023010019
Jul 2023179733
Aug 202398942
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Total 2023961249434
Jan 20241811753
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Apr 20242510948
May 20241212645
Jun 2024511632
Jul 20241312442
Aug 2024139840
Sep 2024119142
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Total 20241731336519
Jan 20251511749
Feb 2025911641
Mar 20251011834
Apr 2025910743
May 20251412744
Jun 20252113454
Jul 20251111340
Aug 20251412571
Sep 2025721639
Oct 20252815637
Nov 20252219163
Dec 20251618174
Total 20251761701589
Jan 2026107119
Total 2026107119
Total132357862499
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Oxytocin Facilitates Allomaternal Behavior under Stress in Laboratory Mice
Yousuke Tsuneoka, Chihiro Yoshihara, Ryuko Ohnishi, Sachine Yoshida, Eri Miyazawa, Masanobu Yamada, Kazuhiko Horiguchi, W. Scott Young, Katsuhiko Nishimori, Tadafumi Kato, Kumi O. Kuroda
eNeuro 11 January 2022, 9 (1) ENEURO.0405-21.2022; DOI: 10.1523/ENEURO.0405-21.2022

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Oxytocin Facilitates Allomaternal Behavior under Stress in Laboratory Mice
Yousuke Tsuneoka, Chihiro Yoshihara, Ryuko Ohnishi, Sachine Yoshida, Eri Miyazawa, Masanobu Yamada, Kazuhiko Horiguchi, W. Scott Young, Katsuhiko Nishimori, Tadafumi Kato, Kumi O. Kuroda
eNeuro 11 January 2022, 9 (1) ENEURO.0405-21.2022; DOI: 10.1523/ENEURO.0405-21.2022
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Keywords

  • maternal behavior
  • medial preoptic area
  • Mus musculus
  • oxytocin
  • vasopressin

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