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Research ArticleResearch Article: Negative Results, Cognition and Behavior

Chronic hM4Di-DREADD-Mediated Chemogenetic Inhibition of Forebrain Excitatory Neurons in Postnatal or Juvenile Life Does Not Alter Adult Mood-Related Behavior

Praachi Tiwari, Darshana Kapri, Amartya Pradhan, Angarika Balakrishnan, Pratik R. Chaudhari and Vidita A. Vaidya
eNeuro 3 February 2022, 9 (1) ENEURO.0381-21.2021; https://doi.org/10.1523/ENEURO.0381-21.2021
Praachi Tiwari
Department of Biological Sciences, Tata Institute of Fundamental Research, Mumbai 400005, India
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Darshana Kapri
Department of Biological Sciences, Tata Institute of Fundamental Research, Mumbai 400005, India
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Amartya Pradhan
Department of Biological Sciences, Tata Institute of Fundamental Research, Mumbai 400005, India
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  • ORCID record for Amartya Pradhan
Angarika Balakrishnan
Department of Biological Sciences, Tata Institute of Fundamental Research, Mumbai 400005, India
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Pratik R. Chaudhari
Department of Biological Sciences, Tata Institute of Fundamental Research, Mumbai 400005, India
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Vidita A. Vaidya
Department of Biological Sciences, Tata Institute of Fundamental Research, Mumbai 400005, India
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  • ORCID record for Vidita A. Vaidya
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0381-21.2021
PubMed 
35115382
Published By 
Society for Neuroscience
History 
  • Received September 19, 2021
  • Revision received December 21, 2021
  • Accepted December 25, 2021
  • Published online February 3, 2022.
Copyright & Usage 
Copyright © 2022 Tiwari et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Praachi Tiwari,
  2. Darshana Kapri,
  3. Amartya Pradhan,
  4. Angarika Balakrishnan,
  5. Pratik R. Chaudhari and
  6. Vidita A. Vaidya
  1. Department of Biological Sciences, Tata Institute of Fundamental Research, Mumbai 400005, India
  1. Correspondence should be addressed to Vidita A. Vaidya at vvaidya{at}tifr.res.in.
View Full Text

Author contributions

  1. Author contributions: P.T. and V.A.V. designed research; P.T., D.K., A.P., A.B., P.R.C., and V.A.V. performed research; P.T., D.K., and A.B. contributed unpublished reagents/analytic tools; P.T., D.K., A.P., and P.R.C. analyzed data; P.T. and V.A.V. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • The study was supported by project RTI4003 from the Department of Atomic Energy to Tata Institute of Fundamental Research, and by the Sree Ramakrishna Paramahamsa Research Grant (2020) from the Sree Padmavathi Venkateswara Foundation (SreePVF), Vijayawada, Andhra Pradesh.

Funding

  • Department of Atomic Energy, Tata Institute of Fundamental Research

    RTI4003
  • Sree Padmavathi Venkateswara Foundation

    Sree Ramakrishna Paramahamsa Research Grant

Other Version

  • You are viewing the most recent version of this article.
  • previous version (February 03, 2022).

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Feb 20221427271333
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May 20242915136
Jun 20241411937
Jul 2024913239
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Jun 2025914228
Jul 20251115540
Aug 20251215242
Sep 20251923251
Oct 20252215234
Nov 20255246
Total 20251311605403
Total204271021945
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Chronic hM4Di-DREADD-Mediated Chemogenetic Inhibition of Forebrain Excitatory Neurons in Postnatal or Juvenile Life Does Not Alter Adult Mood-Related Behavior
Praachi Tiwari, Darshana Kapri, Amartya Pradhan, Angarika Balakrishnan, Pratik R. Chaudhari, Vidita A. Vaidya
eNeuro 3 February 2022, 9 (1) ENEURO.0381-21.2021; DOI: 10.1523/ENEURO.0381-21.2021

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Chronic hM4Di-DREADD-Mediated Chemogenetic Inhibition of Forebrain Excitatory Neurons in Postnatal or Juvenile Life Does Not Alter Adult Mood-Related Behavior
Praachi Tiwari, Darshana Kapri, Amartya Pradhan, Angarika Balakrishnan, Pratik R. Chaudhari, Vidita A. Vaidya
eNeuro 3 February 2022, 9 (1) ENEURO.0381-21.2021; DOI: 10.1523/ENEURO.0381-21.2021
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Keywords

  • anxiety
  • depression
  • DREADD
  • early life
  • Gi signaling
  • schizophrenia

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