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Research ArticleResearch Article: New Research, Disorders of the Nervous System

Protein Profiling of RGS6, a Pleiotropic Gene Implicated in Numerous Neuropsychiatric Disorders, Reveals Multi-Isoformic Expression and a Novel Brain-Specific Isoform

K. E. Ahlers-Dannen, J. Yang, M. M. Spicer, B. Maity, A. Stewart, J. G. Koland and R. A. Fisher
eNeuro 8 December 2021, 9 (1) ENEURO.0379-21.2021; https://doi.org/10.1523/ENEURO.0379-21.2021
K. E. Ahlers-Dannen
Department of Neuroscience and Pharmacology, The Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242
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J. Yang
Department of Neuroscience and Pharmacology, The Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242
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M. M. Spicer
Department of Neuroscience and Pharmacology, The Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242
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B. Maity
Department of Neuroscience and Pharmacology, The Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242
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A. Stewart
Department of Neuroscience and Pharmacology, The Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242
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J. G. Koland
Department of Neuroscience and Pharmacology, The Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242
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R. A. Fisher
Department of Neuroscience and Pharmacology, The Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0379-21.2021
PubMed 
34880111
Published By 
Society for Neuroscience
History 
  • Received September 17, 2021
  • Revision received November 22, 2021
  • Accepted November 24, 2021
  • Published online December 8, 2021.
Copyright & Usage 
Copyright © 2022 Ahlers-Dannen et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. K. E. Ahlers-Dannen,
  2. J. Yang,
  3. M. M. Spicer,
  4. B. Maity,
  5. A. Stewart,
  6. J. G. Koland and
  7. R. A. Fisher
  1. Department of Neuroscience and Pharmacology, The Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242
  1. Correspondence should be addressed to R. A. Fisher at rory-fisher{at}uiowa.edu.
  • B. Maity’s present address: Center of Biomedical Research Lucknow, Uttar Pradesh 226014, India.

  • A. Stewart’s present address: Department of Pharmacology, Florida Atlantic University, Boca Raton, FL 33431.

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Author contributions

  1. Author contributions: K.E.A.-D., J.Y., and R.A.F. designed research; K.E.A.-D., J.Y., M.M.S., B.M., A.S., J.G.K., and R.A.F. performed research; K.E.A.-D., J.Y., and R.A.F. contributed unpublished reagents/analytic tools; K.E.A.-D., J.Y., M.M.S., and R.A.F. analyzed data; K.E.A.-D., J.Y., and R.A.F. wrote the paper.

  • B. Maity’s present address: Center of Biomedical Research Lucknow, Uttar Pradesh 226014, India.

  • A. Stewart’s present address: Department of Pharmacology, Florida Atlantic University, Boca Raton, FL 33431.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by National Institutes of Health Grants CA161882 and AA025919 and MJ Fox Grant 11551.

  • *K.E.A.-D. and J.Y. are co-first authors.

Funding

  • HHS | NIH | National Institute on Alcohol Abuse and Alcoholism (NIAAA)

    AA025919
  • HHS | NIH | National Cancer Institute (NCI)

    CA161882
  • Michael J. Fox Foundation for Parkinson's Research (MJFF)

    MJ Fox 11551

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  • You are viewing the most recent version of this article.
  • previous version (December 08, 2021).

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Dec 2021286099
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Jan 202214813977
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Jul 2025912126
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Total 2025661374262
Jan 20261115326
Feb 2026620425
Mar 20261011742
Apr 202644717
Total 202631521110
Total82246141194
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Protein Profiling of RGS6, a Pleiotropic Gene Implicated in Numerous Neuropsychiatric Disorders, Reveals Multi-Isoformic Expression and a Novel Brain-Specific Isoform
K. E. Ahlers-Dannen, J. Yang, M. M. Spicer, B. Maity, A. Stewart, J. G. Koland, R. A. Fisher
eNeuro 8 December 2021, 9 (1) ENEURO.0379-21.2021; DOI: 10.1523/ENEURO.0379-21.2021

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Protein Profiling of RGS6, a Pleiotropic Gene Implicated in Numerous Neuropsychiatric Disorders, Reveals Multi-Isoformic Expression and a Novel Brain-Specific Isoform
K. E. Ahlers-Dannen, J. Yang, M. M. Spicer, B. Maity, A. Stewart, J. G. Koland, R. A. Fisher
eNeuro 8 December 2021, 9 (1) ENEURO.0379-21.2021; DOI: 10.1523/ENEURO.0379-21.2021
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Keywords

  • expression
  • isoforms
  • neuropsychiatric
  • pleiotropic
  • RGS6
  • splicing

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