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Research ArticleResearch Article: New Research, Disorders of the Nervous System

Long-Term Potentiation of Mossy Fiber Feedforward Inhibition of CA3 Pyramidal Cells Maintains E/I Balance in Epilepsy Model

Enhui Pan, Ram S. Puranam and James O. McNamara
eNeuro 23 December 2021, 9 (1) ENEURO.0375-21.2021; DOI: https://doi.org/10.1523/ENEURO.0375-21.2021
Enhui Pan
1Department of Neurology, Duke University School of Medicine, Durham, NC 27710
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Ram S. Puranam
1Department of Neurology, Duke University School of Medicine, Durham, NC 27710
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James O. McNamara
1Department of Neurology, Duke University School of Medicine, Durham, NC 27710
2Department of Neurobiology, Duke University School of Medicine, Durham, NC 27710
3Department of Pharmacology and Molecular Cancer Biology, Duke University School of Medicine, Durham, NC 27710
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0375-21.2021
PubMed 
34949685
Published By 
Society for Neuroscience
History 
  • Received September 14, 2021
  • Revision received November 11, 2021
  • Accepted December 16, 2021
  • Published online December 23, 2021.
Copyright & Usage 
Copyright © 2022 Pan et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Enhui Pan1,
  2. Ram S. Puranam1 and
  3. James O. McNamara1,2,3
  1. 1Department of Neurology, Duke University School of Medicine, Durham, NC 27710
  2. 2Department of Neurobiology, Duke University School of Medicine, Durham, NC 27710
  3. 3Department of Pharmacology and Molecular Cancer Biology, Duke University School of Medicine, Durham, NC 27710
  1. Correspondence should be addressed to James O. McNamara at jmc{at}neuro.duke.edu.
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Author contributions

  1. Author contributions: J.O.M. and E.P. designed research; E.P. and R.S.P. performed research; J.O.M., E.P., and R.S.P. analyzed data; J.O.M. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by National Institute of Neurological Disorders and Stroke Grants NS097717 and NS056217 (to J.O.M.).

Funding

  • HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS)

    NS097717; NS056217

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  • previous version (December 23, 2021).
  • You are viewing the most recent version of this article.

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eneuro: 9 (1)
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Long-Term Potentiation of Mossy Fiber Feedforward Inhibition of CA3 Pyramidal Cells Maintains E/I Balance in Epilepsy Model
Enhui Pan, Ram S. Puranam, James O. McNamara
eNeuro 23 December 2021, 9 (1) ENEURO.0375-21.2021; DOI: 10.1523/ENEURO.0375-21.2021

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Long-Term Potentiation of Mossy Fiber Feedforward Inhibition of CA3 Pyramidal Cells Maintains E/I Balance in Epilepsy Model
Enhui Pan, Ram S. Puranam, James O. McNamara
eNeuro 23 December 2021, 9 (1) ENEURO.0375-21.2021; DOI: 10.1523/ENEURO.0375-21.2021
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Keywords

  • CA3 pyramidal cells
  • feedforward inhibition
  • homeostatic
  • mossy fiber
  • status epilepticus

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