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Research ArticleResearch Article: New Research, Development

A Shared Transcriptional Identity for Forebrain and Dentate Gyrus Neural Stem Cells from Embryogenesis to Adulthood

Michael J. Borrett, Brendan T. Innes, Nareh Tahmasian, Gary D. Bader, David R. Kaplan and Freda D. Miller
eNeuro 13 January 2022, 9 (1) ENEURO.0271-21.2021; DOI: https://doi.org/10.1523/ENEURO.0271-21.2021
Michael J. Borrett
2Institute of Medical Science, University of Toronto, Toronto, Ontario M5G 1A8, Canada
2Institute of Medical Science, University of Toronto, Toronto, Ontario M5G 1A8, Canada
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Brendan T. Innes
3The Donnelly Centre, University of Toronto, Toronto, Ontario M5G 1A8, Canada
4Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5G 1A8, Canada
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Nareh Tahmasian
2Institute of Medical Science, University of Toronto, Toronto, Ontario M5G 1A8, Canada
2Institute of Medical Science, University of Toronto, Toronto, Ontario M5G 1A8, Canada
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Gary D. Bader
3The Donnelly Centre, University of Toronto, Toronto, Ontario M5G 1A8, Canada
4Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5G 1A8, Canada
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David R. Kaplan
2Institute of Medical Science, University of Toronto, Toronto, Ontario M5G 1A8, Canada
2Institute of Medical Science, University of Toronto, Toronto, Ontario M5G 1A8, Canada
4Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5G 1A8, Canada
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Freda D. Miller
2Institute of Medical Science, University of Toronto, Toronto, Ontario M5G 1A8, Canada
2Institute of Medical Science, University of Toronto, Toronto, Ontario M5G 1A8, Canada
4Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5G 1A8, Canada
5Department of Physiology, University of Toronto, Toronto, Ontario M5G 1A8, Canada
6Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada
7Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0271-21.2021
PubMed 
35027446
Published By 
Society for Neuroscience
History 
  • Received June 15, 2021
  • Revision received November 10, 2021
  • Accepted November 15, 2021
  • Published online January 13, 2022.
Copyright & Usage 
Copyright © 2022 Borrett et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Michael J. Borrett1,2,
  2. Brendan T. Innes3,4,
  3. Nareh Tahmasian1,2,
  4. Gary D. Bader3,4,
  5. David R. Kaplan1,2,4 and
  6. Freda D. Miller1,2,4,5,6,7
  1. 1Program in Neuroscience and Mental Health, Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada
  2. 2Institute of Medical Science, University of Toronto, Toronto, Ontario M5G 1A8, Canada
  3. 3The Donnelly Centre, University of Toronto, Toronto, Ontario M5G 1A8, Canada
  4. 4Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5G 1A8, Canada
  5. 5Department of Physiology, University of Toronto, Toronto, Ontario M5G 1A8, Canada
  6. 6Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada
  7. 7Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada
  1. Correspondence should be addressed to Freda D. Miller at freda.miller{at}msl.ubc.ca.
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Author contributions

  1. Author contributions: M.J.B., B.T.I., G.D.B., D.R.K., and F.D.M. designed research; N.T. performed research; M.J.B., B.T.I., D.R.K., and F.D.M. analyzed data; M.J.B., D.R.K., and F.D.M. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by the Canadian Institutes of Health Research (CIHR) and the Canada First Research Excellence Fund “Medicine by Design” (F.D.M., D.R.K., and G.D.B.). M.J.B. was supported by the CIHR.

Funding

  • Gouvernement du Canada | Canadian Institutes of Health Research (CIHR)

  • CFREF ‘Medicine by Design’

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  • previous version (January 13, 2022).
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A Shared Transcriptional Identity for Forebrain and Dentate Gyrus Neural Stem Cells from Embryogenesis to Adulthood
Michael J. Borrett, Brendan T. Innes, Nareh Tahmasian, Gary D. Bader, David R. Kaplan, Freda D. Miller
eNeuro 13 January 2022, 9 (1) ENEURO.0271-21.2021; DOI: 10.1523/ENEURO.0271-21.2021

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A Shared Transcriptional Identity for Forebrain and Dentate Gyrus Neural Stem Cells from Embryogenesis to Adulthood
Michael J. Borrett, Brendan T. Innes, Nareh Tahmasian, Gary D. Bader, David R. Kaplan, Freda D. Miller
eNeuro 13 January 2022, 9 (1) ENEURO.0271-21.2021; DOI: 10.1523/ENEURO.0271-21.2021
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Keywords

  • forebrain neural stem cells
  • neurodevelopment
  • single-cell RNA-sequencing

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