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Research ArticleResearch Article: New Research, Disorders of the Nervous System

Seizure Prediction in Genetic Rat Models of Absence Epilepsy: Improved Performance through Multiple-Site Cortico-Thalamic Recordings Combined with Machine Learning

Björn Budde, Vladimir Maksimenko, Kelvin Sarink, Thomas Seidenbecher, Gilles van Luijtelaar, Tim Hahn, Hans-Christian Pape and Annika Lüttjohann
eNeuro 15 November 2021, 9 (1) ENEURO.0160-21.2021; https://doi.org/10.1523/ENEURO.0160-21.2021
Björn Budde
1Institute of Physiology I, University of Münster, 48149 Münster, Germany
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Vladimir Maksimenko
2Neuroscience and Cognitive Technology Lab, Innopolis University, 42055 Innopolis, Republic of Tatarstan, Russia
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Kelvin Sarink
3Institute for Translational Psychiatry, University of Münster, 48149 Münster, Germany
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Thomas Seidenbecher
1Institute of Physiology I, University of Münster, 48149 Münster, Germany
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Gilles van Luijtelaar
4Donders Institute for Brain, Cognition and Behavoiur, Radboud University Nijmegen, 6525 GD Nijmegen, The Netherlands
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Tim Hahn
3Institute for Translational Psychiatry, University of Münster, 48149 Münster, Germany
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Hans-Christian Pape
1Institute of Physiology I, University of Münster, 48149 Münster, Germany
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Annika Lüttjohann
1Institute of Physiology I, University of Münster, 48149 Münster, Germany
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0160-21.2021
PubMed 
34782347
Published By 
Society for Neuroscience
History 
  • Received April 13, 2021
  • Revision received October 26, 2021
  • Accepted November 2, 2021
  • Published online November 15, 2021.
Copyright & Usage 
Copyright © 2022 Budde et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Björn Budde1,
  2. Vladimir Maksimenko2,
  3. Kelvin Sarink3,
  4. Thomas Seidenbecher1,
  5. Gilles van Luijtelaar4,
  6. Tim Hahn3,*,
  7. Hans-Christian Pape1,* and
  8. Annika Lüttjohann1,*
  1. 1Institute of Physiology I, University of Münster, 48149 Münster, Germany
  2. 2Neuroscience and Cognitive Technology Lab, Innopolis University, 42055 Innopolis, Republic of Tatarstan, Russia
  3. 3Institute for Translational Psychiatry, University of Münster, 48149 Münster, Germany
  4. 4Donders Institute for Brain, Cognition and Behavoiur, Radboud University Nijmegen, 6525 GD Nijmegen, The Netherlands
  1. Correspondence should be addressed to Annika Lüttjohann at annika.luettjohann{at}ukmuenster.de or Hans-Christian Pape at papechris{at}ukmuenster.de or Tim Hahn at hahnt{at}wwu.de.
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Author contributions

  1. ↵* T.H., H.-C.P., and A.L. contributed equally to this work.

  2. Author contributions: G.v.L., H.-C.P., and A.L. designed research; B.B. performed research; B.B., V.M., K.S., T.S., T.H., and A.L. analyzed data; T.S., G.v.L., T.H., H.-C.P., and A.L. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by the Innovative Medizinische Forschung (IMF) Grant LÜ121603 (to A.L.) and by a German Academic Exchange Service (DAAD) travel grant (V.M.).

Funding

  • Innovative Medizinische Forschung (IMF)

    LÜ121603
  • Deutscher Akademischer Austauschdienst (DAAD)

Other Version

  • You are viewing the most recent version of this article.
  • previous version (November 15, 2021).

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Nov 20213180123
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Jan 2022138041
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Jul 2022511123
Aug 202276814
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Total 20223161038385
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Jul 202367424
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Jan 202499017
Feb 202458522
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May 202468621
Jun 202467412
Jul 202428921
Aug 2024139726
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Total 2024861040210
Jan 2025810118
Feb 2025411019
Mar 2025610929
Apr 2025109719
May 2025811440
Jun 2025127038
Total 202548601163
Total97035661168
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Seizure Prediction in Genetic Rat Models of Absence Epilepsy: Improved Performance through Multiple-Site Cortico-Thalamic Recordings Combined with Machine Learning
Björn Budde, Vladimir Maksimenko, Kelvin Sarink, Thomas Seidenbecher, Gilles van Luijtelaar, Tim Hahn, Hans-Christian Pape, Annika Lüttjohann
eNeuro 15 November 2021, 9 (1) ENEURO.0160-21.2021; DOI: 10.1523/ENEURO.0160-21.2021

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Seizure Prediction in Genetic Rat Models of Absence Epilepsy: Improved Performance through Multiple-Site Cortico-Thalamic Recordings Combined with Machine Learning
Björn Budde, Vladimir Maksimenko, Kelvin Sarink, Thomas Seidenbecher, Gilles van Luijtelaar, Tim Hahn, Hans-Christian Pape, Annika Lüttjohann
eNeuro 15 November 2021, 9 (1) ENEURO.0160-21.2021; DOI: 10.1523/ENEURO.0160-21.2021
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Keywords

  • absence epilepsy
  • artificial neuronal network
  • GAERS
  • random forest
  • somatosensory cortex
  • spike and wave discharges

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