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Research ArticleResearch Article: New Research, Cognition and Behavior

Dorsal Raphe 5-HT Neurons Utilize, But Do Not Generate, Negative Aversive Prediction Errors

Rachel A. Walker, Rebecca L. Suthard, Taylor N. Perison, Nora M. Sheehan, Caitlin C. Dwyer, Jillian K. Lee, Eghosa K. Enabulele, Madelyn H. Ray and Michael A. McDannald
eNeuro 25 January 2022, 9 (1) ENEURO.0132-21.2022; DOI: https://doi.org/10.1523/ENEURO.0132-21.2022
Rachel A. Walker
Department of Psychology and Neuroscience, Boston College, Chestnut Hill, MA 02467
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Rebecca L. Suthard
Department of Psychology and Neuroscience, Boston College, Chestnut Hill, MA 02467
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Taylor N. Perison
Department of Psychology and Neuroscience, Boston College, Chestnut Hill, MA 02467
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Nora M. Sheehan
Department of Psychology and Neuroscience, Boston College, Chestnut Hill, MA 02467
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Caitlin C. Dwyer
Department of Psychology and Neuroscience, Boston College, Chestnut Hill, MA 02467
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Jillian K. Lee
Department of Psychology and Neuroscience, Boston College, Chestnut Hill, MA 02467
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Eghosa K. Enabulele
Department of Psychology and Neuroscience, Boston College, Chestnut Hill, MA 02467
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Madelyn H. Ray
Department of Psychology and Neuroscience, Boston College, Chestnut Hill, MA 02467
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Michael A. McDannald
Department of Psychology and Neuroscience, Boston College, Chestnut Hill, MA 02467
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0132-21.2022
PubMed 
35078807
Published By 
Society for Neuroscience
History 
  • Received March 30, 2021
  • Revision received December 29, 2021
  • Accepted January 11, 2022
  • Published online January 25, 2022.
Copyright & Usage 
Copyright © 2022 Walker et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Rachel A. Walker,
  2. Rebecca L. Suthard,
  3. Taylor N. Perison,
  4. Nora M. Sheehan,
  5. Caitlin C. Dwyer,
  6. Jillian K. Lee,
  7. Eghosa K. Enabulele,
  8. Madelyn H. Ray and
  9. Michael A. McDannald
  1. Department of Psychology and Neuroscience, Boston College, Chestnut Hill, MA 02467
  1. Correspondence should be addressed to Rachel A. Walker at rachel.a.zacharias{at}gmail.com or Michael A. McDannald at michael.mcdannald{at}bc.edu.
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Author contributions

  1. Author contributions: R.A.W. and M.A.M. designed research; R.A.W., R.L.S., T.N.P., N.M.S., C.C.D., J.K.L., E.K.E., M.H.R., and M.A.M. performed research; R.A.W. and M.A.M. analyzed data; R.A.W. and M.A.M. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by National Institutes of Health National Institute of Mental Health Grants R01MH117791 and R00DA034010 (to M.A.M.).

Funding

  • HHS | NIH | National Institute of Mental Health (NIMH)

    R01MH117791; R00DA034010

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Dorsal Raphe 5-HT Neurons Utilize, But Do Not Generate, Negative Aversive Prediction Errors
Rachel A. Walker, Rebecca L. Suthard, Taylor N. Perison, Nora M. Sheehan, Caitlin C. Dwyer, Jillian K. Lee, Eghosa K. Enabulele, Madelyn H. Ray, Michael A. McDannald
eNeuro 25 January 2022, 9 (1) ENEURO.0132-21.2022; DOI: 10.1523/ENEURO.0132-21.2022

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Dorsal Raphe 5-HT Neurons Utilize, But Do Not Generate, Negative Aversive Prediction Errors
Rachel A. Walker, Rebecca L. Suthard, Taylor N. Perison, Nora M. Sheehan, Caitlin C. Dwyer, Jillian K. Lee, Eghosa K. Enabulele, Madelyn H. Ray, Michael A. McDannald
eNeuro 25 January 2022, 9 (1) ENEURO.0132-21.2022; DOI: 10.1523/ENEURO.0132-21.2022
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Keywords

  • discrimination
  • extinction
  • fear
  • prediction error
  • serotonin
  • Tph2-cre

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