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Research ArticleResearch Article: New Research, Cognition and Behavior

FKBP51 in the Oval Bed Nucleus of the Stria Terminalis Regulates Anxiety-Like Behavior

Clara Engelhardt, Fiona Tang, Radwa Elkhateib, Joeri Bordes, Lea Maria Brix, Lotte van Doeselaar, Alexander S. Häusl, Max L. Pöhlmann, Karla Schraut, Huanqing Yang, Alon Chen, Jan M. Deussing and Mathias V. Schmidt
eNeuro 6 December 2021, 8 (6) ENEURO.0425-21.2021; https://doi.org/10.1523/ENEURO.0425-21.2021
Clara Engelhardt
1Research Group Neurobiology of Stress Resilience, Max Planck Institute of Psychiatry, Munich 80804, Germany
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Fiona Tang
1Research Group Neurobiology of Stress Resilience, Max Planck Institute of Psychiatry, Munich 80804, Germany
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Radwa Elkhateib
1Research Group Neurobiology of Stress Resilience, Max Planck Institute of Psychiatry, Munich 80804, Germany
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Joeri Bordes
1Research Group Neurobiology of Stress Resilience, Max Planck Institute of Psychiatry, Munich 80804, Germany
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Lea Maria Brix
1Research Group Neurobiology of Stress Resilience, Max Planck Institute of Psychiatry, Munich 80804, Germany
2International Max Planck Research School for Translational Psychiatry (IMPRS-TP), Munich 80804, Germany
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  • ORCID record for Lea Maria Brix
Lotte van Doeselaar
1Research Group Neurobiology of Stress Resilience, Max Planck Institute of Psychiatry, Munich 80804, Germany
2International Max Planck Research School for Translational Psychiatry (IMPRS-TP), Munich 80804, Germany
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Alexander S. Häusl
1Research Group Neurobiology of Stress Resilience, Max Planck Institute of Psychiatry, Munich 80804, Germany
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Max L. Pöhlmann
1Research Group Neurobiology of Stress Resilience, Max Planck Institute of Psychiatry, Munich 80804, Germany
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Karla Schraut
1Research Group Neurobiology of Stress Resilience, Max Planck Institute of Psychiatry, Munich 80804, Germany
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Huanqing Yang
1Research Group Neurobiology of Stress Resilience, Max Planck Institute of Psychiatry, Munich 80804, Germany
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Alon Chen
3Department of Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Munich 80804, Germany
4Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel
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Jan M. Deussing
5Research Group Molecular Neurogenetics, Max Planck Institute of Psychiatry, Munich 80804, Germany
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Mathias V. Schmidt
1Research Group Neurobiology of Stress Resilience, Max Planck Institute of Psychiatry, Munich 80804, Germany
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0425-21.2021
PubMed 
34872938
Published By 
Society for Neuroscience
History 
  • Received October 11, 2021
  • Revision received November 11, 2021
  • Accepted November 15, 2021
  • Published online December 6, 2021.
Copyright & Usage 
Copyright © 2021 Engelhardt et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Clara Engelhardt1,
  2. Fiona Tang1,
  3. Radwa Elkhateib1,
  4. Joeri Bordes1,
  5. Lea Maria Brix1,2,
  6. Lotte van Doeselaar1,2,
  7. Alexander S. Häusl1,
  8. Max L. Pöhlmann1,
  9. Karla Schraut1,
  10. Huanqing Yang1,
  11. Alon Chen3,4,
  12. Jan M. Deussing5 and
  13. Mathias V. Schmidt1
  1. 1Research Group Neurobiology of Stress Resilience, Max Planck Institute of Psychiatry, Munich 80804, Germany
  2. 2International Max Planck Research School for Translational Psychiatry (IMPRS-TP), Munich 80804, Germany
  3. 3Department of Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Munich 80804, Germany
  4. 4Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel
  5. 5Research Group Molecular Neurogenetics, Max Planck Institute of Psychiatry, Munich 80804, Germany
  1. Correspondence should be addressed to Mathias V. Schmidt at mschmidt{at}psych.mpg.de.
View Full Text

Author contributions

  1. Author contributions: M.V.S. designed research; C.E., F.T., R.E., J.B., L.M.B., L.v.D., A.S.H., M.L.P., K.S., and H.Y. performed research; A.C. and J.M.D. contributed unpublished reagents/analytic tools; C.E. and F.T. analyzed data; C.E. and M.V.S. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by the “OptiMD” grant of the Federal Ministry of Education and Research (01EE1401D; to M.V.S.) and the “Kids2Health” grant of the Federal Ministry of Education and Research (01GL1743C; to M.V.S.).

Funding

  • Bundesministerium für Bildung und Forschung (BMBF)

    01EE1401D; 01GL1743C

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  • You are viewing the most recent version of this article.
  • previous version (December 06, 2021).

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Dec 2021728383269
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Jan 202217934977
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Jun 202268920
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Total 2023611052212
Jan 2024310025
Feb 2024107530
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Apr 20241611130
May 20241210223
Jun 2024259513
Jul 2024910623
Aug 202479017
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Total 20241161148254
Jan 20251010633
Feb 20251211018
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Apr 202529312
May 20251310314
Jun 2025611022
Jul 2025911242
Aug 2025911618
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Dec 2025918435
Total 20251181600271
Jan 20261119124
Feb 20261439024
Mar 202674015
Total 20263262163
Total134061061478
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FKBP51 in the Oval Bed Nucleus of the Stria Terminalis Regulates Anxiety-Like Behavior
Clara Engelhardt, Fiona Tang, Radwa Elkhateib, Joeri Bordes, Lea Maria Brix, Lotte van Doeselaar, Alexander S. Häusl, Max L. Pöhlmann, Karla Schraut, Huanqing Yang, Alon Chen, Jan M. Deussing, Mathias V. Schmidt
eNeuro 6 December 2021, 8 (6) ENEURO.0425-21.2021; DOI: 10.1523/ENEURO.0425-21.2021

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FKBP51 in the Oval Bed Nucleus of the Stria Terminalis Regulates Anxiety-Like Behavior
Clara Engelhardt, Fiona Tang, Radwa Elkhateib, Joeri Bordes, Lea Maria Brix, Lotte van Doeselaar, Alexander S. Häusl, Max L. Pöhlmann, Karla Schraut, Huanqing Yang, Alon Chen, Jan M. Deussing, Mathias V. Schmidt
eNeuro 6 December 2021, 8 (6) ENEURO.0425-21.2021; DOI: 10.1523/ENEURO.0425-21.2021
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Keywords

  • anxiety
  • BNST
  • FKBP5
  • mouse
  • stress

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