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Research ArticleResearch Article: New Research, Neuronal Excitability

Precision Mapping of Amyloid-β Binding Reveals Perisynaptic Localization and Spatially Restricted Plasticity Deficits

Hannah S. Actor-Engel, Samantha L. Schwartz, Kevin C. Crosby, Brooke L. Sinnen, Olga Prikhodko, Harrison J. Ramsay, Jennifer N. Bourne, Christina S. Winborn, Alexandra Lucas, Katharine R. Smith, Mark L. Dell’Acqua and Matthew J. Kennedy
eNeuro 17 November 2021, 8 (6) ENEURO.0416-21.2021; DOI: https://doi.org/10.1523/ENEURO.0416-21.2021
Hannah S. Actor-Engel
1Department of Pharmacology, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO 80045
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Samantha L. Schwartz
1Department of Pharmacology, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO 80045
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Kevin C. Crosby
1Department of Pharmacology, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO 80045
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Brooke L. Sinnen
1Department of Pharmacology, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO 80045
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Olga Prikhodko
1Department of Pharmacology, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO 80045
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Harrison J. Ramsay
1Department of Pharmacology, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO 80045
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  • ORCID record for Harrison J. Ramsay
Jennifer N. Bourne
2Electron Microscopy Core, University of Colorado Anschutz Medical Campus, Aurora, CO 80045
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Christina S. Winborn
1Department of Pharmacology, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO 80045
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Alexandra Lucas
1Department of Pharmacology, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO 80045
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Katharine R. Smith
1Department of Pharmacology, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO 80045
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Mark L. Dell’Acqua
1Department of Pharmacology, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO 80045
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Matthew J. Kennedy
1Department of Pharmacology, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO 80045
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0416-21.2021
PubMed 
34789478
Published By 
Society for Neuroscience
History 
  • Received October 4, 2021
  • Revision received November 3, 2021
  • Accepted November 11, 2021
  • Published online November 17, 2021.
Copyright & Usage 
Copyright © 2021 Actor-Engel et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Hannah S. Actor-Engel1,
  2. Samantha L. Schwartz1,
  3. Kevin C. Crosby1,
  4. Brooke L. Sinnen1,
  5. Olga Prikhodko1,
  6. Harrison J. Ramsay1,
  7. Jennifer N. Bourne2†,
  8. Christina S. Winborn1,
  9. Alexandra Lucas1,
  10. Katharine R. Smith1,
  11. Mark L. Dell’Acqua1 and
  12. Matthew J. Kennedy1
  1. 1Department of Pharmacology, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO 80045
  2. 2Electron Microscopy Core, University of Colorado Anschutz Medical Campus, Aurora, CO 80045
  1. Correspondence should be addressed to Matthew J. Kennedy at matthew.kennedy{at}cuanschutz.edu.
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Author contributions

  1. Author contributions: H.S.A.-E., M.L.D., and M.J.K. designed research; H.S.A.-E., S.L.S., B.L.S., O.P., H.J.R., J.N.B., C.S.W., A.L., and M.J.K. performed research; K.R.S. contributed unpublished reagents/analytic tools; H.S.A.-E., S.L.S., K.C.C., B.L.S., O.P., and H.J.R. analyzed data; H.S.A.-E. and M.J.K. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by National Institute of Neurological Disorders and Stroke Grants R35NS116879 (to M.J.K.) and NS110383 (to M.J.K. and M.L.D.), National Institute on Aging Grants T32AG000279 (to H.S.A.-E.) and AG058005 (to M.J.K.), and the National Institute of Mental Health Grant R01MH119154 (to K.R.S.).

Funding

  • HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS)

    NS110383; NS116879
  • HHS | NIH | National Institute of Mental Health (NIMH)

    MH119154; F32MH123053
  • HHS | NIH | National Institute on Aging (NIA)

    T32AG000279; AG058005

Other Version

  • previous version (November 17, 2021).
  • You are viewing the most recent version of this article.

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Precision Mapping of Amyloid-β Binding Reveals Perisynaptic Localization and Spatially Restricted Plasticity Deficits
Hannah S. Actor-Engel, Samantha L. Schwartz, Kevin C. Crosby, Brooke L. Sinnen, Olga Prikhodko, Harrison J. Ramsay, Jennifer N. Bourne, Christina S. Winborn, Alexandra Lucas, Katharine R. Smith, Mark L. Dell’Acqua, Matthew J. Kennedy
eNeuro 17 November 2021, 8 (6) ENEURO.0416-21.2021; DOI: 10.1523/ENEURO.0416-21.2021

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Precision Mapping of Amyloid-β Binding Reveals Perisynaptic Localization and Spatially Restricted Plasticity Deficits
Hannah S. Actor-Engel, Samantha L. Schwartz, Kevin C. Crosby, Brooke L. Sinnen, Olga Prikhodko, Harrison J. Ramsay, Jennifer N. Bourne, Christina S. Winborn, Alexandra Lucas, Katharine R. Smith, Mark L. Dell’Acqua, Matthew J. Kennedy
eNeuro 17 November 2021, 8 (6) ENEURO.0416-21.2021; DOI: 10.1523/ENEURO.0416-21.2021
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Keywords

  • amyloid-β
  • LTP
  • plasticity
  • postsynaptic density
  • super-resolution
  • synapse

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