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Research ArticleResearch Article: New Research, Disorders of the Nervous System

Drug-Induced Hyperglycemia as a Potential Contributor to Translational Failure of Uncompetitive NMDA Receptor Antagonists

Eric Yuhsiang Wang and Ted Weita Lai
eNeuro 3 December 2021, 8 (6) ENEURO.0346-21.2021; https://doi.org/10.1523/ENEURO.0346-21.2021
Eric Yuhsiang Wang
1Graduate Institute of Biomedical Sciences, China Medical University, Taichung 404, Taiwan
2School of Medicine, China Medical University, Taichung 404, Taiwan
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Ted Weita Lai
1Graduate Institute of Biomedical Sciences, China Medical University, Taichung 404, Taiwan
2School of Medicine, China Medical University, Taichung 404, Taiwan
3Drug Development Center, China Medical University, Taichung 404, Taiwan
4Translational Medicine Research Center, China Medical University Hospital, Taichung 404, Taiwan
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0346-21.2021
PubMed 
34862204
Published By 
Society for Neuroscience
History 
  • Received August 21, 2021
  • Revision received October 24, 2021
  • Accepted November 26, 2021
  • Published online December 3, 2021.
Copyright & Usage 
Copyright © 2021 Wang and Lai This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Eric Yuhsiang Wang1,2 and
  2. Ted Weita Lai1,2,3,4
  1. 1Graduate Institute of Biomedical Sciences, China Medical University, Taichung 404, Taiwan
  2. 2School of Medicine, China Medical University, Taichung 404, Taiwan
  3. 3Drug Development Center, China Medical University, Taichung 404, Taiwan
  4. 4Translational Medicine Research Center, China Medical University Hospital, Taichung 404, Taiwan
  1. Correspondence should be addressed to Ted Weita Lai at ted.weita{at}me.com.
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Author contributions

  1. Author contributions: E.Y.W. and T.W.L. designed research; E.Y.W. performed research; E.Y.W. and T.W.L. analyzed data; T.W.L. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by research grants from the China Medical University (CMU109-MF-28), Ministry of Science and Technology (MOST109-2320-B-039-010), National Health Research Institutes (NHRI-EX110-10803NI), and Drug Development Center, China Medical University, from the Featured Areas Research Center Program within the framework of the Higher Education Sprout Project by the Ministry of Education in Taiwan. E.Y.W. was supported by an undergraduate student research award from the Ministry of Science and Technology (MOST110-2813-C-039-027-B).

Funding

  • China Medical University (CMU) [Taiwan]

    CMU109-MF-28
  • Ministry of Science and Technology, Taiwan (MOST)

    MOST109-2320-B-039-010
  • National Health Research Institutes (NHRI)

    NHRI-EX110-10803NI

Other Version

  • You are viewing the most recent version of this article.
  • previous version (December 03, 2021).

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Dec 202138734143
Total 202138734143
Jan 202213527770
Feb 20222739241
Mar 20221211833
Apr 2022118630
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Jun 202298511
Jul 202286510
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Jan 202326113
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Apr 20230793
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Jul 20232868
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Total 2023441037108
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May 2024109713
Jun 202478210
Jul 202468212
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Jan 2025109716
Feb 2025210111
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Jun 202598425
Jul 20251511538
Aug 202589730
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Oct 20251311824
Nov 20251811215
Dec 20251112324
Total 20251151253235
Jan 2026138914
Total 2026138914
Total8735069901
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eneuro: 8 (6)
eNeuro
Vol. 8, Issue 6
November/December 2021
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Drug-Induced Hyperglycemia as a Potential Contributor to Translational Failure of Uncompetitive NMDA Receptor Antagonists
Eric Yuhsiang Wang, Ted Weita Lai
eNeuro 3 December 2021, 8 (6) ENEURO.0346-21.2021; DOI: 10.1523/ENEURO.0346-21.2021

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Drug-Induced Hyperglycemia as a Potential Contributor to Translational Failure of Uncompetitive NMDA Receptor Antagonists
Eric Yuhsiang Wang, Ted Weita Lai
eNeuro 3 December 2021, 8 (6) ENEURO.0346-21.2021; DOI: 10.1523/ENEURO.0346-21.2021
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Keywords

  • circadian
  • excitotoxicity
  • hyperglycemia
  • neuroprotection
  • NMDA receptor
  • stroke

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