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Research ArticleResearch Article: New Research, Disorders of the Nervous System

Dysregulated mRNA Translation in the G2019S LRRK2 and LRRK2 Knock-Out Mouse Brains

Jungwoo Wren Kim, Xiling Yin, Ian Martin, Yulan Xiong, Stephen M. Eacker, Nicholas T. Ingolia, Ted M. Dawson and Valina L. Dawson
eNeuro 10 November 2021, 8 (6) ENEURO.0310-21.2021; DOI: https://doi.org/10.1523/ENEURO.0310-21.2021
Jungwoo Wren Kim
1Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205
2Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205
3Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720
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  • ORCID record for Jungwoo Wren Kim
Xiling Yin
1Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205
4Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205
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Ian Martin
1Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205
4Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205
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Yulan Xiong
1Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205
4Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205
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Stephen M. Eacker
1Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205
4Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205
5Adrienne Helis Malvin Medical Research Foundation, New Orleans, LA 70130
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Nicholas T. Ingolia
3Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720
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Ted M. Dawson
1Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205
4Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205
5Adrienne Helis Malvin Medical Research Foundation, New Orleans, LA 70130
6Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205
7Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205
8Diana Helis Henry Medical Research Foundation, New Orleans, LA 70130
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Valina L. Dawson
1Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205
2Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205
4Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205
5Adrienne Helis Malvin Medical Research Foundation, New Orleans, LA 70130
6Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205
8Diana Helis Henry Medical Research Foundation, New Orleans, LA 70130
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0310-21.2021
PubMed 
34759048
Published By 
Society for Neuroscience
History 
  • Received July 20, 2021
  • Revision received October 4, 2021
  • Accepted October 28, 2021
  • Published online November 10, 2021.
Copyright & Usage 
Copyright © 2021 Kim et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Jungwoo Wren Kim1,2,3,
  2. Xiling Yin1,4,
  3. Ian Martin1,4,
  4. Yulan Xiong1,4,
  5. Stephen M. Eacker1,4,5,
  6. Nicholas T. Ingolia3,
  7. Ted M. Dawson1,4,5,6,7,8 and
  8. Valina L. Dawson1,2,4,5,6,8
  1. 1Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205
  2. 2Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205
  3. 3Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720
  4. 4Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205
  5. 5Adrienne Helis Malvin Medical Research Foundation, New Orleans, LA 70130
  6. 6Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205
  7. 7Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205
  8. 8Diana Helis Henry Medical Research Foundation, New Orleans, LA 70130
  1. Correspondence should be addressed to Valina L. Dawson at vdawson{at}jhmi.edu or Ted M. Dawson at tdawson{at}jhmi.edu.
  • I. Martin’s present address: Jungers Center for Neurosciences Research, Parkinson Center of Oregon, Department of Neurology, Oregon Health and Science University, Portland, OR 97239.

  • Y. Xiong’s present address: Department of Neuroscience, University of Connecticut School of Medicine, Farmington, CT 06030.

  • S. M. Eacker’s present address: Phase Genomics Inc, Seattle, WA 98109.

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Author contributions

  1. Author contributions: J.W.K., T.M.D., and V.L.D. designed research; J.W.K., X.Y., I.M., Y.X., and N.T.I. performed research; J.W.K. and S.M.E. contributed unpublished reagents/analytic tools; J.W.K., X.Y., I.M., and N.T.I. analyzed data; J.W.K., T.M.D., and V.L.D. wrote the paper.

  • I. Martin’s present address: Jungers Center for Neurosciences Research, Parkinson Center of Oregon, Department of Neurology, Oregon Health and Science University, Portland, OR 97239.

  • Y. Xiong’s present address: Department of Neuroscience, University of Connecticut School of Medicine, Farmington, CT 06030.

  • S. M. Eacker’s present address: Phase Genomics Inc, Seattle, WA 98109.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by the National Institutes of Health (NIH) Grant P50 NS38377, the JPB Foundation, and the Adrienne Helis Malvin Medical Research Foundation’s Parkinson’s Disease Program M-2014. J.W.K was supported by Korea Foundation of Advanced Studies. I.M. was supported by the NIH/National Institute on Aging (NIA) Grant K01-01AG050718. Y.X. was supported by NIH/NIA Grant K01-AG046366 and The William N. & Bernice E. Bumpus Foundation Innovation Awards.

Funding

  • NIH

    P50 NS38377; K01-01AG050718; K01-AG046366
  • The JPB Foundation

  • Adrienne Helis Malvin Medical Research Foundation

    M-2014
  • Korea Foundation for Advanced Studies (KFAS)

  • The William N. & Bernice E. Bumpus Foundation

Other Version

  • previous version (November 10, 2021).
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Dysregulated mRNA Translation in the G2019S LRRK2 and LRRK2 Knock-Out Mouse Brains
Jungwoo Wren Kim, Xiling Yin, Ian Martin, Yulan Xiong, Stephen M. Eacker, Nicholas T. Ingolia, Ted M. Dawson, Valina L. Dawson
eNeuro 10 November 2021, 8 (6) ENEURO.0310-21.2021; DOI: 10.1523/ENEURO.0310-21.2021

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Dysregulated mRNA Translation in the G2019S LRRK2 and LRRK2 Knock-Out Mouse Brains
Jungwoo Wren Kim, Xiling Yin, Ian Martin, Yulan Xiong, Stephen M. Eacker, Nicholas T. Ingolia, Ted M. Dawson, Valina L. Dawson
eNeuro 10 November 2021, 8 (6) ENEURO.0310-21.2021; DOI: 10.1523/ENEURO.0310-21.2021
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Keywords

  • LRRK2
  • RPS15
  • translation

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