Figure 3. Wheel-running activity acquired by the WRAQ system under different entrainment schedules. A–D, Actograms of mouse wheel-running activity under LD (A), DD (B), and LL (C, D) conditions. E, Bar graph of the presumptive distance traveled on the wheel for mice kept under LD (gray), DD (black), and LL (white) entrainment. F, Line plots of the periodograms analyzing wheel-running activity recorded for 8 d under LD (blue, n = 10), DD (gray, n = 10), and LL (red, n = 7) based on the Lomb–Scargle method. Data are presented as mean (solid lines) ± SEM (error bars and shading). Contrasts are statistically significant differences of mean values between groups (repeated-measures ANOVA followed by Tukey’s post hoc test); *p < 0.05, †p < 0.01, ‡p < 0.001.