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Research ArticleResearch Article: New Research, Neuronal Excitability

TRPM4 Contributes to Subthreshold Membrane Potential Oscillations in Multiple Mouse Pacemaker Neurons

Keyong Li, Yingtang Shi, Elizabeth C. Gonye and Douglas A. Bayliss
eNeuro 3 November 2021, 8 (6) ENEURO.0212-21.2021; DOI: https://doi.org/10.1523/ENEURO.0212-21.2021
Keyong Li
Department of Pharmacology, University of Virginia, Charlottesville, VA 22908
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Yingtang Shi
Department of Pharmacology, University of Virginia, Charlottesville, VA 22908
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Elizabeth C. Gonye
Department of Pharmacology, University of Virginia, Charlottesville, VA 22908
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Douglas A. Bayliss
Department of Pharmacology, University of Virginia, Charlottesville, VA 22908
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0212-21.2021
PubMed 
34732535
Published By 
Society for Neuroscience
History 
  • Received May 11, 2021
  • Revision received October 13, 2021
  • Accepted October 21, 2021
  • Published online November 3, 2021.
Copyright & Usage 
Copyright © 2021 Li et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Keyong Li,
  2. Yingtang Shi,
  3. Elizabeth C. Gonye and
  4. Douglas A. Bayliss
  1. Department of Pharmacology, University of Virginia, Charlottesville, VA 22908
  1. Correspondence should be addressed to Douglas A. Bayliss at bayliss{at}virginia.edu.
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Author contributions

  1. Author contributions: K.L. and D.A.B. designed research; K.L. and E.C.G. performed research; Y.S. contributed unpublished reagents/analytic tools; K.L., E.C.G., and D.A.B. analyzed data; K.L. and D.A.B. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by the National Heart, Lung, and Blood Institute Grant R01 HL108609 (to D.A.B.).

Funding

  • HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI)

    HL108609

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  • previous version (November 03, 2021).
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eneuro: 8 (6)
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November/December 2021
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TRPM4 Contributes to Subthreshold Membrane Potential Oscillations in Multiple Mouse Pacemaker Neurons
Keyong Li, Yingtang Shi, Elizabeth C. Gonye, Douglas A. Bayliss
eNeuro 3 November 2021, 8 (6) ENEURO.0212-21.2021; DOI: 10.1523/ENEURO.0212-21.2021

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TRPM4 Contributes to Subthreshold Membrane Potential Oscillations in Multiple Mouse Pacemaker Neurons
Keyong Li, Yingtang Shi, Elizabeth C. Gonye, Douglas A. Bayliss
eNeuro 3 November 2021, 8 (6) ENEURO.0212-21.2021; DOI: 10.1523/ENEURO.0212-21.2021
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Keywords

  • calcium-dependent
  • cationic current
  • ICaN
  • tonic firing
  • TRP channels
  • waveform command

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