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Research ArticleResearch Article: New Research, Novel Tools and Methods

Level of hM4D(Gi) DREADD Expression Determines Inhibitory and Neurotoxic Effects in the Hippocampus

Marie-Gabrielle Goossens, Lars Emil Larsen, Marijke Vergaelen, Wytse Wadman, Chris Van den Haute, Wayra Brackx, Silke Proesmans, Jana Desloovere, Emma Christiaen, Erine Craey, Christian Vanhove, Kristl Vonck, Paul Boon and Robrecht Raedt
eNeuro 7 October 2021, 8 (6) ENEURO.0105-21.2021; DOI: https://doi.org/10.1523/ENEURO.0105-21.2021
Marie-Gabrielle Goossens
14BRAIN, Department Head and Skin, Ghent University, Ghent 9000, Belgium
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Lars Emil Larsen
14BRAIN, Department Head and Skin, Ghent University, Ghent 9000, Belgium
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Marijke Vergaelen
14BRAIN, Department Head and Skin, Ghent University, Ghent 9000, Belgium
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  • ORCID record for Marijke Vergaelen
Wytse Wadman
14BRAIN, Department Head and Skin, Ghent University, Ghent 9000, Belgium
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Chris Van den Haute
2Laboratory for Neurobiology and Gene Therapy, Center for Molecular Medicine and Leuven Brain Institute, Katholieke Universiteit Leuven, Leuven 3000, Belgium
3Leuven Viral Vector Core, Center for Molecular Medicine, Katholieke Universiteit Leuven, Leuven 3000, Belgium
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Wayra Brackx
4Department of Basic and Applied Medical Sciences, Ghent University, Ghent 9000, Belgium
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Silke Proesmans
14BRAIN, Department Head and Skin, Ghent University, Ghent 9000, Belgium
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Jana Desloovere
14BRAIN, Department Head and Skin, Ghent University, Ghent 9000, Belgium
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Emma Christiaen
5Medisip, Department Electronics and Information Systems, Ghent University, Ghent 9000, Belgium
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Erine Craey
14BRAIN, Department Head and Skin, Ghent University, Ghent 9000, Belgium
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Christian Vanhove
5Medisip, Department Electronics and Information Systems, Ghent University, Ghent 9000, Belgium
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Kristl Vonck
14BRAIN, Department Head and Skin, Ghent University, Ghent 9000, Belgium
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Paul Boon
14BRAIN, Department Head and Skin, Ghent University, Ghent 9000, Belgium
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Robrecht Raedt
14BRAIN, Department Head and Skin, Ghent University, Ghent 9000, Belgium
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Level of hM4D(Gi) DREADD Expression Determines Inhibitory and Neurotoxic Effects in the Hippocampus
Marie-Gabrielle Goossens, Lars Emil Larsen, Marijke Vergaelen, Wytse Wadman, Chris Van den Haute, Wayra Brackx, Silke Proesmans, Jana Desloovere, Emma Christiaen, Erine Craey, Christian Vanhove, Kristl Vonck, Paul Boon, Robrecht Raedt
eNeuro 7 October 2021, 8 (6) ENEURO.0105-21.2021; DOI: 10.1523/ENEURO.0105-21.2021

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Level of hM4D(Gi) DREADD Expression Determines Inhibitory and Neurotoxic Effects in the Hippocampus
Marie-Gabrielle Goossens, Lars Emil Larsen, Marijke Vergaelen, Wytse Wadman, Chris Van den Haute, Wayra Brackx, Silke Proesmans, Jana Desloovere, Emma Christiaen, Erine Craey, Christian Vanhove, Kristl Vonck, Paul Boon, Robrecht Raedt
eNeuro 7 October 2021, 8 (6) ENEURO.0105-21.2021; DOI: 10.1523/ENEURO.0105-21.2021
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Keywords

  • chemogenetics
  • DREADD
  • hippocampus
  • neurotoxicity
  • rat
  • viral vector

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