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Research ArticleResearch Article: New Research, Disorders of the Nervous System

Intrauterine Growth Restriction Causes Abnormal Embryonic Dentate Gyrus Neurogenesis in Mouse Offspring That Leads to Adult Learning and Memory Deficits

Ashley S. Brown, Matthew Wieben, Shelby Murdock, Jill Chang, Maria L. V. Dizon, Mark St. Pierre, Raul Chavez-Valdez, Richard I. Dorsky and Camille M. Fung
eNeuro 20 September 2021, 8 (5) ENEURO.0062-21.2021; https://doi.org/10.1523/ENEURO.0062-21.2021
Ashley S. Brown
1Division of Neonatology, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah 84158
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Matthew Wieben
2University of Utah, Salt Lake City, Utah 84108
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Shelby Murdock
2University of Utah, Salt Lake City, Utah 84108
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Jill Chang
3Division of Neonatology, Department of Pediatrics, Northwestern University, Chicago, Illinois 60611
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Maria L. V. Dizon
3Division of Neonatology, Department of Pediatrics, Northwestern University, Chicago, Illinois 60611
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Mark St. Pierre
4Division of Neonatology, Department of Pediatrics, Johns Hopkins University, Baltimore, Maryland 21287
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Raul Chavez-Valdez
4Division of Neonatology, Department of Pediatrics, Johns Hopkins University, Baltimore, Maryland 21287
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Richard I. Dorsky
5Department of Neurobiology and Anatomy, University of Utah, Salt Lake City, Utah 84108
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Camille M. Fung
1Division of Neonatology, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah 84158
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0062-21.2021
PubMed 
34544755
Published By 
Society for Neuroscience
History 
  • Received February 14, 2021
  • Revision received September 8, 2021
  • Accepted September 14, 2021
  • Published online September 20, 2021.
Copyright & Usage 
Copyright © 2021 Brown et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Ashley S. Brown1,
  2. Matthew Wieben2,
  3. Shelby Murdock2,
  4. Jill Chang3,
  5. Maria L. V. Dizon3,
  6. Mark St. Pierre4,
  7. Raul Chavez-Valdez4,
  8. Richard I. Dorsky5 and
  9. Camille M. Fung1
  1. 1Division of Neonatology, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah 84158
  2. 2University of Utah, Salt Lake City, Utah 84108
  3. 3Division of Neonatology, Department of Pediatrics, Northwestern University, Chicago, Illinois 60611
  4. 4Division of Neonatology, Department of Pediatrics, Johns Hopkins University, Baltimore, Maryland 21287
  5. 5Department of Neurobiology and Anatomy, University of Utah, Salt Lake City, Utah 84108
  1. Correspondence should be addressed to Camille M. Fung at camille.fung{at}hsc.utah.edu.
View Full Text

Author contributions

  1. Author contributions: A.S.B., R.C.-V., R.I.D., and C.M.F. designed research; A.S.B., M.W., S.M., J.C., R.C.-V., M.S.P., and C.M.F. performed research; A.S.B., M.W., S.M., J.C., M.L.V.D., R.C.-V., and C.M.F. analyzed data; M.L.V.D., R.C.-V., R.I.D., and C.M.F. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • M.L.V.D. is supported by National Institute of Neurological Disorders and Stroke (NINDS) Grant R01-NS-086945. R.C.V. is supported by NINDS Grant K08-NS-096115, the JHU-SOM Clinician Scientist Award, and The Thomas Wilson Foundation. The majority of funding for this work was provided by the Division of Pediatric Neonatology at the University of Utah School of Medicine.

Funding

  • HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS)

    R01NS086945; K08NS096115

Other Version

  • You are viewing the most recent version of this article.
  • previous version (September 20, 2021).

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Article usage: September 2021 to January 2026

AbstractFullPdf
Sep 20212370109
Oct 2021187282126
Nov 20213719559
Dec 20211612445
Total 2021477601339
Jan 20221611631
Feb 2022106125
Mar 2022188428
Apr 202278028
May 2022511329
Jun 2022110217
Jul 202238324
Aug 202276615
Sep 202235027
Oct 202268024
Nov 202256917
Dec 202255919
Total 202286963284
Jan 202326434
Feb 20230588
Mar 202306414
Apr 20234688
May 20231729
Jun 202328515
Jul 202349022
Aug 202336927
Sep 202386628
Oct 202388716
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Dec 202349316
Total 202344896215
Jan 202457714
Feb 202458219
Mar 202468316
Apr 202458319
May 202459016
Jun 2024139022
Jul 202449426
Aug 2024119428
Sep 202479928
Oct 2024510618
Nov 202478325
Dec 202478412
Total 2024801065243
Jan 202598918
Feb 2025109720
Mar 202559011
Apr 202549318
May 202599723
Jun 20252110120
Jul 20251616638
Aug 2025118027
Sep 2025614326
Oct 20251411624
Nov 20251715130
Dec 20251913849
Total 20251411361304
Jan 20263311768
Total 20263311768
Total86150031453
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Intrauterine Growth Restriction Causes Abnormal Embryonic Dentate Gyrus Neurogenesis in Mouse Offspring That Leads to Adult Learning and Memory Deficits
Ashley S. Brown, Matthew Wieben, Shelby Murdock, Jill Chang, Maria L. V. Dizon, Mark St. Pierre, Raul Chavez-Valdez, Richard I. Dorsky, Camille M. Fung
eNeuro 20 September 2021, 8 (5) ENEURO.0062-21.2021; DOI: 10.1523/ENEURO.0062-21.2021

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Intrauterine Growth Restriction Causes Abnormal Embryonic Dentate Gyrus Neurogenesis in Mouse Offspring That Leads to Adult Learning and Memory Deficits
Ashley S. Brown, Matthew Wieben, Shelby Murdock, Jill Chang, Maria L. V. Dizon, Mark St. Pierre, Raul Chavez-Valdez, Richard I. Dorsky, Camille M. Fung
eNeuro 20 September 2021, 8 (5) ENEURO.0062-21.2021; DOI: 10.1523/ENEURO.0062-21.2021
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Keywords

  • embryonic dentate gyrus neurogenesis
  • fetal growth restriction
  • hypertensive disease of pregnancy
  • intrauterine growth restriction
  • learning and memory
  • neural stem cell

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