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Research ArticleResearch Article: New Research, Disorders of the Nervous System

High Behavioral Variability Mediated by Altered Neuronal Excitability in auts2 Mutant Zebrafish

Urvashi Jha, Igor Kondrychyn, Vladimir Korzh and Vatsala Thirumalai
eNeuro 20 September 2021, 8 (5) ENEURO.0493-20.2021; https://doi.org/10.1523/ENEURO.0493-20.2021
Urvashi Jha
1National Centre for Biological Sciences, Tata Institute of Fundamental Research, Bangalore 560065, India
2School of Chemical and Biotechnology, SASTRA Deemed University, Thanjavur 613401, India
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Igor Kondrychyn
1National Centre for Biological Sciences, Tata Institute of Fundamental Research, Bangalore 560065, India
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  • ORCID record for Igor Kondrychyn
Vladimir Korzh
3Institute of Molecular and Cell Biology, Proteos 138673, Singapore
4International Institute of Molecular and Cell Biology, Warsaw 02-109, Poland
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Vatsala Thirumalai
1National Centre for Biological Sciences, Tata Institute of Fundamental Research, Bangalore 560065, India
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0493-20.2021
PubMed 
34544758
Published By 
Society for Neuroscience
History 
  • Received November 17, 2020
  • Revision received August 25, 2021
  • Accepted August 27, 2021
  • Published online September 20, 2021.
Copyright & Usage 
Copyright © 2021 Jha et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Urvashi Jha1,2,*,
  2. Igor Kondrychyn1,*,
  3. Vladimir Korzh3,4 and
  4. Vatsala Thirumalai1
  1. 1National Centre for Biological Sciences, Tata Institute of Fundamental Research, Bangalore 560065, India
  2. 2School of Chemical and Biotechnology, SASTRA Deemed University, Thanjavur 613401, India
  3. 3Institute of Molecular and Cell Biology, Proteos 138673, Singapore
  4. 4International Institute of Molecular and Cell Biology, Warsaw 02-109, Poland
  1. Correspondence should be addressed to Vatsala Thirumalai at vatsala{at}ncbs.res.in.
  • I. Kondrychyn’s present address: RIKEN Center for Biosystems Dynamics Research, Kobe 650-0047, Japan.

  • Vladimir Korzh’s present address: International Institute of Molecular and Cell Biology, Warsaw 02-109, Poland.

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Author contributions

  1. Author contributions: U.J., I.K., and V.T. designed research; U.J. and I.K. performed research; V.K. contributed unpublished reagents/analytic tools; U.J., I.K., and V.T. analyzed data; U.J., I.K., and V.T. wrote the paper.

  2. ↵* U.J. and I.K. contributed equally to this work.

  • I. Kondrychyn’s present address: RIKEN Center for Biosystems Dynamics Research, Kobe 650-0047, Japan.

  • Vladimir Korzh’s present address: International Institute of Molecular and Cell Biology, Warsaw 02-109, Poland.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by Wellcome Trust-Department of Biotechnology India Alliance Intermediate and Senior fellowships (V.T.), Department of Biotechnology (V.T.), Science and Engineering Research Board, Department of Science and Technology (V.T.), the Department of Atomic Energy Grant VT-12-R&D-TFR-5.04-0800, a Council of Scientific and Industrial Research-University Grants Commission fellowship (U.J.), a National Centre for Biological Sciences Career Development Fellowship (I.K.). V.K.’s laboratory in the Institute of Molecular and Cellular Biology, Singapore was supported by the institutional grant to the IMCB by the Agency for Science, Technology and Research of Singapore. V.K. in Poland was supported by the Opus grant of the National Science Foundation (NCN), Poland (2016/21/B/NZ3/00354) and 2020/39/B/NZ3/02729.

Funding

  • Council for Scientific and Industrial Research, India

  • NCBS Career Development Fellowship

  • Wellcome Trust DBT India Alliance

    500040/Z/09/Z and IA/S/17/2/503297
  • Department of Biotechnology , Ministry of Science and Technology (DBT)

    BT/PR4983/MED/30/790 /2012
  • DST | Science and Engineering Research Board (SERB)

    EMR/2015/000595
  • Department of Atomic Energy, Government of India (DAE)

    VT-12-R&D-TFR-5.04-0800
  • Agency for Science, Technology and Research (A*STAR)

  • Narodowe Centrum Nauki (NCN)

    2016/21/B/NZ3/00354

Other Version

  • You are viewing the most recent version of this article.
  • previous version (September 20, 2021).

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Sep 2021320089
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Jul 202549714
Aug 2025910716
Sep 20251713421
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Total 2025871319280
Jan 20261014130
Feb 2026417314
Total 20261431444
Total90372411311
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High Behavioral Variability Mediated by Altered Neuronal Excitability in auts2 Mutant Zebrafish
Urvashi Jha, Igor Kondrychyn, Vladimir Korzh, Vatsala Thirumalai
eNeuro 20 September 2021, 8 (5) ENEURO.0493-20.2021; DOI: 10.1523/ENEURO.0493-20.2021

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High Behavioral Variability Mediated by Altered Neuronal Excitability in auts2 Mutant Zebrafish
Urvashi Jha, Igor Kondrychyn, Vladimir Korzh, Vatsala Thirumalai
eNeuro 20 September 2021, 8 (5) ENEURO.0493-20.2021; DOI: 10.1523/ENEURO.0493-20.2021
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Keywords

  • C-start
  • calcium imaging
  • escape behavior
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