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Research ArticleResearch Article: New Research, Disorders of the Nervous System

Altered Cerebellar Response to Somatosensory Stimuli in the Cntnap2 Mouse Model of Autism

Marta Fernández, Carlos A. Sánchez-León, Javier Llorente, Teresa Sierra-Arregui, Shira Knafo, Javier Márquez-Ruiz and Olga Peñagarikano
eNeuro 30 September 2021, 8 (5) ENEURO.0333-21.2021; DOI: https://doi.org/10.1523/ENEURO.0333-21.2021
Marta Fernández
1Department of Pharmacology, University of the Basque Country (UPV/EHU), Leioa 48940, Spain
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Carlos A. Sánchez-León
2Department of Physiology, Anatomy and Cellular Biology, Pablo de Olavide University, Seville 41013, Spain
3Leibniz Research Center for Working Environment and Human Factors, Department of Psychology and Neurosciences, Technical University Dortmund, Dortmund 44227, Germany
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Javier Llorente
1Department of Pharmacology, University of the Basque Country (UPV/EHU), Leioa 48940, Spain
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Teresa Sierra-Arregui
1Department of Pharmacology, University of the Basque Country (UPV/EHU), Leioa 48940, Spain
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Shira Knafo
4Department of Physiology and Cell Biology, The National Institute for Biotechnology in the Negev, and The Zlotowski Center for Neuroscience, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel
6Ikerbasque, Basque Foundation for Science and Instituto Biofisika, Leioa 48940, Spain
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Javier Márquez-Ruiz
2Department of Physiology, Anatomy and Cellular Biology, Pablo de Olavide University, Seville 41013, Spain
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  • ORCID record for Javier Márquez-Ruiz
Olga Peñagarikano
1Department of Pharmacology, University of the Basque Country (UPV/EHU), Leioa 48940, Spain
5Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Leioa 48940, Spain
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0333-21.2021
PubMed 
34593517
Published By 
Society for Neuroscience
History 
  • Received August 12, 2021
  • Revision received September 1, 2021
  • Accepted September 13, 2021
  • Published online September 30, 2021.
Copyright & Usage 
Copyright © 2021 Fernández et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Marta Fernández1,
  2. Carlos A. Sánchez-León2,3,
  3. Javier Llorente1,
  4. Teresa Sierra-Arregui1,
  5. Shira Knafo4,6,
  6. Javier Márquez-Ruiz2 and
  7. Olga Peñagarikano1,5
  1. 1Department of Pharmacology, University of the Basque Country (UPV/EHU), Leioa 48940, Spain
  2. 2Department of Physiology, Anatomy and Cellular Biology, Pablo de Olavide University, Seville 41013, Spain
  3. 3Leibniz Research Center for Working Environment and Human Factors, Department of Psychology and Neurosciences, Technical University Dortmund, Dortmund 44227, Germany
  4. 4Department of Physiology and Cell Biology, The National Institute for Biotechnology in the Negev, and The Zlotowski Center for Neuroscience, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel
  5. 5Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Leioa 48940, Spain
  6. 6Ikerbasque, Basque Foundation for Science and Instituto Biofisika, Leioa 48940, Spain
  1. Correspondence should be addressed to Marta Fernández at marta.fernandez{at}ehu.eus or Javier Llorente at javier.llorente{at}ehu.eus.
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Author contributions

  1. Author contributions: S.K., J.M.-R., and O.P. designed research; M.F., C.A.S.-L., J.L., and T.S.-A. performed research; M.F., C.A.S.-L., J.L., and T.S.-A. analyzed data; S.K., J.M.-R., and O.P. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by the Spanish Ministry of Science (MCIU/AEl/FEDER) Grant RTI2018-101427-B-I00 (to O.P.), the ERANET-NEURON Grant nEUrotalk (to O.P.), the University of the Basque Country (UPV/EHU) Grant GIU18/094 (to O.P.), the Israel Science Foundation Grant 536/19 (to S.K.), the Spanish Ministry of Science Grant SAF2016-78071-R (to S.K.), and the Spanish Ministry of Economy (MINECO-FEDER) Grant BFU2017-89615-P (to J.M.-R.). M.F. holds the MINECO Predoctoral Fellowship BES-2016–078420, and T.S.-A. is a Basque Government predoctoral fellow (PRE-2020–2-0109).

Funding

  • Ministerio de Ciencia e Innovación (MICINN)

    RTI2018-101427-B-I00; SAF2016-78071-R; BFU2017-89615-P

Other Version

  • You are viewing the most recent version of this article.
  • previous version (September 30, 2021).

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Altered Cerebellar Response to Somatosensory Stimuli in the Cntnap2 Mouse Model of Autism
Marta Fernández, Carlos A. Sánchez-León, Javier Llorente, Teresa Sierra-Arregui, Shira Knafo, Javier Márquez-Ruiz, Olga Peñagarikano
eNeuro 30 September 2021, 8 (5) ENEURO.0333-21.2021; DOI: 10.1523/ENEURO.0333-21.2021

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Altered Cerebellar Response to Somatosensory Stimuli in the Cntnap2 Mouse Model of Autism
Marta Fernández, Carlos A. Sánchez-León, Javier Llorente, Teresa Sierra-Arregui, Shira Knafo, Javier Márquez-Ruiz, Olga Peñagarikano
eNeuro 30 September 2021, 8 (5) ENEURO.0333-21.2021; DOI: 10.1523/ENEURO.0333-21.2021
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Keywords

  • autism
  • Cerebellum
  • cntnap2
  • complex spike
  • Purkinje
  • sensory stimuli

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