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Research ArticleResearch Article: New Research, Disorders of the Nervous System

Beneficial Effects of Transplanted Human Bone Marrow Endothelial Progenitors on Functional and Cellular Components of Blood-Spinal Cord Barrier in ALS Mice

Svitlana Garbuzova-Davis, Kayla J. Boccio, Alexander Llauget, Robert Shell, Surafuale Hailu, Hilmi Mustafa, Jared Ehrhart, Paul R. Sanberg, Stanley H. Appel and Cesario V. Borlongan
eNeuro 3 September 2021, 8 (5) ENEURO.0314-21.2021; https://doi.org/10.1523/ENEURO.0314-21.2021
Svitlana Garbuzova-Davis
1Center of Excellence for Aging and Brain Repair, University of South Florida, Morsani College of Medicine, Tampa, FL 33612
2Department of Neurosurgery and Brain Repair, University of South Florida, Morsani College of Medicine, Tampa, FL 33612
3Department of Molecular Pharmacology and Physiology, University of South Florida, Morsani College of Medicine, Tampa, FL 33612
4Department of Pathology and Cell Biology, University of South Florida, Morsani College of Medicine, Tampa, FL 33612
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  • ORCID record for Svitlana Garbuzova-Davis
Kayla J. Boccio
1Center of Excellence for Aging and Brain Repair, University of South Florida, Morsani College of Medicine, Tampa, FL 33612
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Alexander Llauget
1Center of Excellence for Aging and Brain Repair, University of South Florida, Morsani College of Medicine, Tampa, FL 33612
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Robert Shell
1Center of Excellence for Aging and Brain Repair, University of South Florida, Morsani College of Medicine, Tampa, FL 33612
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Surafuale Hailu
1Center of Excellence for Aging and Brain Repair, University of South Florida, Morsani College of Medicine, Tampa, FL 33612
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Hilmi Mustafa
1Center of Excellence for Aging and Brain Repair, University of South Florida, Morsani College of Medicine, Tampa, FL 33612
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Jared Ehrhart
1Center of Excellence for Aging and Brain Repair, University of South Florida, Morsani College of Medicine, Tampa, FL 33612
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Paul R. Sanberg
1Center of Excellence for Aging and Brain Repair, University of South Florida, Morsani College of Medicine, Tampa, FL 33612
2Department of Neurosurgery and Brain Repair, University of South Florida, Morsani College of Medicine, Tampa, FL 33612
4Department of Pathology and Cell Biology, University of South Florida, Morsani College of Medicine, Tampa, FL 33612
5Department of Psychiatry, University of South Florida, Morsani College of Medicine, Tampa, FL 33612
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Stanley H. Appel
6Stanley H. Appel Department of Neurology, Houston Methodist Neurological Institute, Houston, TX 77030
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Cesario V. Borlongan
1Center of Excellence for Aging and Brain Repair, University of South Florida, Morsani College of Medicine, Tampa, FL 33612
2Department of Neurosurgery and Brain Repair, University of South Florida, Morsani College of Medicine, Tampa, FL 33612
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0314-21.2021
PubMed 
34479980
Published By 
Society for Neuroscience
History 
  • Received July 24, 2021
  • Revision received August 26, 2021
  • Accepted August 30, 2021
  • Published online September 3, 2021.
Copyright & Usage 
Copyright © 2021 Garbuzova-Davis et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Svitlana Garbuzova-Davis1,2,3,4,
  2. Kayla J. Boccio1,
  3. Alexander Llauget1,
  4. Robert Shell1,
  5. Surafuale Hailu1,
  6. Hilmi Mustafa1,
  7. Jared Ehrhart1,
  8. Paul R. Sanberg1,2,4,5,
  9. Stanley H. Appel6 and
  10. Cesario V. Borlongan1,2
  1. 1Center of Excellence for Aging and Brain Repair, University of South Florida, Morsani College of Medicine, Tampa, FL 33612
  2. 2Department of Neurosurgery and Brain Repair, University of South Florida, Morsani College of Medicine, Tampa, FL 33612
  3. 3Department of Molecular Pharmacology and Physiology, University of South Florida, Morsani College of Medicine, Tampa, FL 33612
  4. 4Department of Pathology and Cell Biology, University of South Florida, Morsani College of Medicine, Tampa, FL 33612
  5. 5Department of Psychiatry, University of South Florida, Morsani College of Medicine, Tampa, FL 33612
  6. 6Stanley H. Appel Department of Neurology, Houston Methodist Neurological Institute, Houston, TX 77030
  1. Correspondence should be addressed to Svitlana Garbuzova-Davis at sgarbuzo{at}usf.edu.
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Author contributions

  1. Author contributions: S.G.-D., P.R.S., S.H.A., and C.V.B. designed research; K.J.B., A.L., R.S., S.H., H.M., and J.E. performed research; S.G.-D., K.J.B., A.L., R.S., S.H., and J.E. analyzed data; S.G.-D. and H.M. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by the National Institutes of Health National Institute of Neurological Disorders and Stroke Grant 1R01NS090962.

Funding

  • NIH, NINDS

    1R01NS090962

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  • previous version (September 03, 2021).

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Sep 2021765285239
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Nov 202123141168
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Total 2021891939557
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Jul 202408425
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Total 202429957200
Jan 202568013
Feb 2025011518
Mar 202539720
Apr 202518511
May 202537614
Jun 20250233
Total 20251347679
Total104540651401
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Beneficial Effects of Transplanted Human Bone Marrow Endothelial Progenitors on Functional and Cellular Components of Blood-Spinal Cord Barrier in ALS Mice
Svitlana Garbuzova-Davis, Kayla J. Boccio, Alexander Llauget, Robert Shell, Surafuale Hailu, Hilmi Mustafa, Jared Ehrhart, Paul R. Sanberg, Stanley H. Appel, Cesario V. Borlongan
eNeuro 3 September 2021, 8 (5) ENEURO.0314-21.2021; DOI: 10.1523/ENEURO.0314-21.2021

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Beneficial Effects of Transplanted Human Bone Marrow Endothelial Progenitors on Functional and Cellular Components of Blood-Spinal Cord Barrier in ALS Mice
Svitlana Garbuzova-Davis, Kayla J. Boccio, Alexander Llauget, Robert Shell, Surafuale Hailu, Hilmi Mustafa, Jared Ehrhart, Paul R. Sanberg, Stanley H. Appel, Cesario V. Borlongan
eNeuro 3 September 2021, 8 (5) ENEURO.0314-21.2021; DOI: 10.1523/ENEURO.0314-21.2021
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Keywords

  • ALS
  • blood-spinal cord barrier
  • G93A SOD1 mice
  • human bone marrow-derived stem cells
  • repair
  • transplantation

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