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Research ArticleResearch Article: New Research, Sensory and Motor Systems

Effects of Cooling Temperatures via Thermal K2P Channels on Regeneration of High-Frequency Action Potentials at Nodes of Ranvier of Rat Aβ-Afferent Nerves

Hirosato Kanda, Sotatsu Tonomura and Jianguo G. Gu
eNeuro 30 August 2021, 8 (5) ENEURO.0308-21.2021; https://doi.org/10.1523/ENEURO.0308-21.2021
Hirosato Kanda
1Department of Anesthesiology and Perioperative Medicine, School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294
2Department of Pharmacology, Hyogo University of Health Sciences, Kobe, Hyogo 650-8530, Japan
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Sotatsu Tonomura
1Department of Anesthesiology and Perioperative Medicine, School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294
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Jianguo G. Gu
1Department of Anesthesiology and Perioperative Medicine, School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0308-21.2021
PubMed 
34462308
Published By 
Society for Neuroscience
History 
  • Received July 19, 2021
  • Revision received July 28, 2021
  • Accepted August 17, 2021
  • Published online August 30, 2021.
Copyright & Usage 
Copyright © 2021 Kanda et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Hirosato Kanda1,2,
  2. Sotatsu Tonomura1 and
  3. Jianguo G. Gu1
  1. 1Department of Anesthesiology and Perioperative Medicine, School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294
  2. 2Department of Pharmacology, Hyogo University of Health Sciences, Kobe, Hyogo 650-8530, Japan
  1. Correspondence should be addressed to Jianguo G. Gu at jianguogu{at}uabmc.edu.
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Author contributions

  1. Author contributions: J.G.G. designed research; H.K. and S.T. performed research; H.K., S.T., and J.G.G. analyzed data; J.G.G. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by National Institutes of Health Grants NS109059, DE023090, and DE018661 (to J.G.G.).

Funding

  • HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS)

    NS109059
  • HHS | NIH | National Institute of Dental and Craniofacial Research (NIDCR)

    DE023090; DE018661

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  • You are viewing the most recent version of this article.
  • previous version (August 30, 2021).

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Aug 202133013
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Jun 2025107717
Jul 20251160
Total 20252650171
Total5493695805
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September/October 2021
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Effects of Cooling Temperatures via Thermal K2P Channels on Regeneration of High-Frequency Action Potentials at Nodes of Ranvier of Rat Aβ-Afferent Nerves
Hirosato Kanda, Sotatsu Tonomura, Jianguo G. Gu
eNeuro 30 August 2021, 8 (5) ENEURO.0308-21.2021; DOI: 10.1523/ENEURO.0308-21.2021

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Effects of Cooling Temperatures via Thermal K2P Channels on Regeneration of High-Frequency Action Potentials at Nodes of Ranvier of Rat Aβ-Afferent Nerves
Hirosato Kanda, Sotatsu Tonomura, Jianguo G. Gu
eNeuro 30 August 2021, 8 (5) ENEURO.0308-21.2021; DOI: 10.1523/ENEURO.0308-21.2021
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Keywords

  • Aβ-afferent nerves
  • action potential
  • cooling temperature
  • node of Ranvier
  • saltatory conduction
  • two-pore domain K+ channels

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