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Research ArticleResearch Article: New Research, Sensory and Motor Systems

Functional Characterization of Ovine Dorsal Root Ganglion Neurons Reveal Peripheral Sensitization after Osteochondral Defect

Sampurna Chakrabarti, Minji Ai, Katherine Wong, Karin Newell, Frances M. D. Henson and Ewan St. John Smith
eNeuro 20 September 2021, 8 (5) ENEURO.0237-21.2021; https://doi.org/10.1523/ENEURO.0237-21.2021
Sampurna Chakrabarti
1Department of Neuroscience, Max-Delbrück-Centrum für Molekulare Medizin (MDC), Berlin, Germany, 13125
2Department of Pharmacology, University of Cambridge, Cambridge, United Kingdom, CB2 1PD
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Minji Ai
3Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom, CB3 0ES
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Katherine Wong
2Department of Pharmacology, University of Cambridge, Cambridge, United Kingdom, CB2 1PD
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Karin Newell
3Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom, CB3 0ES
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Frances M. D. Henson
3Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom, CB3 0ES
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Ewan St. John Smith
2Department of Pharmacology, University of Cambridge, Cambridge, United Kingdom, CB2 1PD
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0237-21.2021
PubMed 
34544757
Published By 
Society for Neuroscience
History 
  • Received May 20, 2021
  • Revision received August 12, 2021
  • Accepted September 1, 2021
  • Published online September 20, 2021.
Copyright & Usage 
Copyright © 2021 Chakrabarti et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Sampurna Chakrabarti1,2,^,
  2. Minji Ai3,^,
  3. Katherine Wong2,
  4. Karin Newell3,
  5. Frances M. D. Henson3 and
  6. Ewan St. John Smith2
  1. 1Department of Neuroscience, Max-Delbrück-Centrum für Molekulare Medizin (MDC), Berlin, Germany, 13125
  2. 2Department of Pharmacology, University of Cambridge, Cambridge, United Kingdom, CB2 1PD
  3. 3Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom, CB3 0ES
  1. Correspondence should be addressed to Ewan St. John Smith at es336{at}cam.ac.uk or Frances M. D. Henson at fmdh1{at}cam.ac.uk.
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Author contributions

  1. Author contributions: S.C., M.A., K.N., F.M.D.H., and E.S.J.S. designed research; S.C., M.A., K.W., and K.N. performed research; S.C., M.A., K.W., and F.M.D.H. analyzed data; S.C., M.A., K.N., F.M.D.H., and E.S.J.S. wrote the paper.

  2. ↵^ S.C. and M.A contributed equally to this work.

Disclosures

  • The authors declare no competing financial interests.

  • S.C. was supported by the Gates Cambridge Trust Scholarship. This work was supported by the Versus Arthritis Grants RG21973 and the Biotechnology and Biological Sciences Research Council Grant BB/R006210/1 (to E.S.J.S.) and by the Horizon 2020 Grant RG90905 and the Innovate UK Grant RG87266 (to F.M.D.H.).

Funding

  • Gates Cambridge Trust

  • Versus Arthritis

    RG21973
  • Biotechnology and Biological Sciences Research Council (BBSRC)

    BB/R006210/1
  • EC | Horizon 2020 (EU Framework Programme for Research and Innovation)

    RG90905
  • Innovate UK

    RG87266

Other Version

  • You are viewing the most recent version of this article.
  • previous version (September 20, 2021).

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Sep 2021170098
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Total 2021371780343
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Total 202255896248
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Jun 2025710120
Jul 2025910422
Aug 202569122
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Total 2025621070200
Total55949331232
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Functional Characterization of Ovine Dorsal Root Ganglion Neurons Reveal Peripheral Sensitization after Osteochondral Defect
Sampurna Chakrabarti, Minji Ai, Katherine Wong, Karin Newell, Frances M. D. Henson, Ewan St. John Smith
eNeuro 20 September 2021, 8 (5) ENEURO.0237-21.2021; DOI: 10.1523/ENEURO.0237-21.2021

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Functional Characterization of Ovine Dorsal Root Ganglion Neurons Reveal Peripheral Sensitization after Osteochondral Defect
Sampurna Chakrabarti, Minji Ai, Katherine Wong, Karin Newell, Frances M. D. Henson, Ewan St. John Smith
eNeuro 20 September 2021, 8 (5) ENEURO.0237-21.2021; DOI: 10.1523/ENEURO.0237-21.2021
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Keywords

  • knee
  • neuron
  • osteochondral defect
  • pain
  • sheep model

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