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Research ArticleResearch Article: New Research, Neuronal Excitability

The Impact of SST and PV Interneurons on Nonlinear Synaptic Integration in the Neocortex

Christopher Dorsett, Benjamin D. Philpot, Spencer LaVere Smith and Ikuko T. Smith
eNeuro 16 August 2021, 8 (5) ENEURO.0235-21.2021; DOI: https://doi.org/10.1523/ENEURO.0235-21.2021
Christopher Dorsett
1Neuroscience Center, Neurobiology Curriculum, University of North Carolina, Chapel Hill, North Carolina 27599
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Benjamin D. Philpot
1Neuroscience Center, Neurobiology Curriculum, University of North Carolina, Chapel Hill, North Carolina 27599
2Department of Cell Biology and Physiology, Carolina Institute for Developmental Disabilities, University of North Carolina, Chapel Hill, North Carolina 27599
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Spencer LaVere Smith
3Department of Electrical & Computer Engineering, University of California, Santa Barbara, Santa Barbara, California 93106
4Neuroscience Research Institute, University of California, Santa Barbara, Santa Barbara, California 93106
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Ikuko T. Smith
4Neuroscience Research Institute, University of California, Santa Barbara, Santa Barbara, California 93106
5Department of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, Santa Barbara, California 93106
6Department of Psychological & Brain Sciences, University of California, Santa Barbara, Santa Barbara, California 93106
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0235-21.2021
PubMed 
34400470
Published By 
Society for Neuroscience
History 
  • Received May 25, 2021
  • Revision received July 26, 2021
  • Accepted August 9, 2021
  • Published online August 16, 2021.
Copyright & Usage 
Copyright © 2021 Dorsett et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Christopher Dorsett1,
  2. Benjamin D. Philpot1,2,
  3. Spencer LaVere Smith3,4 and
  4. Ikuko T. Smith4,5,6
  1. 1Neuroscience Center, Neurobiology Curriculum, University of North Carolina, Chapel Hill, North Carolina 27599
  2. 2Department of Cell Biology and Physiology, Carolina Institute for Developmental Disabilities, University of North Carolina, Chapel Hill, North Carolina 27599
  3. 3Department of Electrical & Computer Engineering, University of California, Santa Barbara, Santa Barbara, California 93106
  4. 4Neuroscience Research Institute, University of California, Santa Barbara, Santa Barbara, California 93106
  5. 5Department of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, Santa Barbara, California 93106
  6. 6Department of Psychological & Brain Sciences, University of California, Santa Barbara, Santa Barbara, California 93106
  1. Correspondence should be addressed to Spencer LaVere Smith at sls{at}ucsb.edu or Ikuko T. Smith at ikukots{at}ucsb.edu.
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Author contributions

  1. Author contributions: C.D., B.D.P., S.L.S., and I.T.S. designed research; C.D. performed research; C.D. analyzed data; C.D., B.D.P., S.L.S., and I.T.S. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by National Institutes of Health Grant (NIH) R01-NS-091335, National Science Foundation Grant 1707287, the Human Frontier Science Program, the Klingenstein Foundation, and the Simons Foundation (to S.L.S); NIH Grant R01-NS-114086 (to B.D.P.); and a Helen Lyng White Fellowship (to I.T.S).

Funding

  • HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS)

    R01NS091335; R01NS114086; T32NS007431
  • National Science Foundation (NSF)

    1707287
  • Simons Foundation

    325407SS
  • Helen Lyng White Fellowship

Other Version

  • You are viewing the most recent version of this article.
  • previous version (August 16, 2021).

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Aug 20212590225
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Total 20237395109
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eneuro: 8 (5)
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September/October 2021
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The Impact of SST and PV Interneurons on Nonlinear Synaptic Integration in the Neocortex
Christopher Dorsett, Benjamin D. Philpot, Spencer LaVere Smith, Ikuko T. Smith
eNeuro 16 August 2021, 8 (5) ENEURO.0235-21.2021; DOI: 10.1523/ENEURO.0235-21.2021

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The Impact of SST and PV Interneurons on Nonlinear Synaptic Integration in the Neocortex
Christopher Dorsett, Benjamin D. Philpot, Spencer LaVere Smith, Ikuko T. Smith
eNeuro 16 August 2021, 8 (5) ENEURO.0235-21.2021; DOI: 10.1523/ENEURO.0235-21.2021
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Keywords

  • dendrites
  • inhibition
  • interneurons
  • nonlinearity
  • synaptic integration

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