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Research ArticleResearch Article: New Research, Sensory and Motor Systems

Photoreceptor cKO of OTX2 Enhances OTX2 Intercellular Transfer in the Retina and Causes Photophobia

Pasquale Pensieri, Annabelle Mantilleri, Damien Plassard, Takahisa Furukawa, Kenneth L. Moya, Alain Prochiantz and Thomas Lamonerie
eNeuro 2 September 2021, 8 (5) ENEURO.0229-21.2021; https://doi.org/10.1523/ENEURO.0229-21.2021
Pasquale Pensieri
1Université Côte d’Azur, Centre National de la Recherche Scientifique, Institut National de la Santé et de la Recherche Médicale, Institut de Biologie Valrose, Nice 06108, France
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Annabelle Mantilleri
1Université Côte d’Azur, Centre National de la Recherche Scientifique, Institut National de la Santé et de la Recherche Médicale, Institut de Biologie Valrose, Nice 06108, France
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Damien Plassard
2Plateforme GenomEast, Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch 67404, France
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Takahisa Furukawa
3Laboratory for Molecular and Developmental Biology, Institute for Protein Research, Osaka University, Osaka 565-0871, Japan
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  • ORCID record for Takahisa Furukawa
Kenneth L. Moya
4Centre for Interdisciplinary Research in Biology (CIRB), Collège de France, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 7241, Institut National de la Santé et de la Recherche Médicale Unité 1050, Paris 75005, France
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Alain Prochiantz
4Centre for Interdisciplinary Research in Biology (CIRB), Collège de France, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 7241, Institut National de la Santé et de la Recherche Médicale Unité 1050, Paris 75005, France
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Thomas Lamonerie
1Université Côte d’Azur, Centre National de la Recherche Scientifique, Institut National de la Santé et de la Recherche Médicale, Institut de Biologie Valrose, Nice 06108, France
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0229-21.2021
PubMed 
34475267
Published By 
Society for Neuroscience
History 
  • Received May 20, 2021
  • Revision received July 26, 2021
  • Accepted August 3, 2021
  • Published online September 2, 2021.
Copyright & Usage 
Copyright © 2021 Pensieri et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Pasquale Pensieri1,*,
  2. Annabelle Mantilleri1,*,
  3. Damien Plassard2,
  4. Takahisa Furukawa3,
  5. Kenneth L. Moya4,
  6. Alain Prochiantz4 and
  7. Thomas Lamonerie1
  1. 1Université Côte d’Azur, Centre National de la Recherche Scientifique, Institut National de la Santé et de la Recherche Médicale, Institut de Biologie Valrose, Nice 06108, France
  2. 2Plateforme GenomEast, Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch 67404, France
  3. 3Laboratory for Molecular and Developmental Biology, Institute for Protein Research, Osaka University, Osaka 565-0871, Japan
  4. 4Centre for Interdisciplinary Research in Biology (CIRB), Collège de France, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 7241, Institut National de la Santé et de la Recherche Médicale Unité 1050, Paris 75005, France
  1. Correspondence should be addressed to Thomas Lamonerie at thomas.lamonerie{at}univ-cotedazur.fr.
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Author contributions

  1. Author contributions: K.L.M., A.P., and T.L. designed research; P.P., A.M., and D.P. performed research; T.F. contributed unpublished reagents/analytic tools; P.P., A.M., D.P., T.F., K.L.M., A.P., and T.L. analyzed data; T.L. wrote the paper.

  2. ↵* P.P. and A.M. contributed equally to this work.

Disclosures

  • K.L.M. and A.P. are listed on patents for the use of homeoproteins to treat neurodegenerative disease, and each holds equity in a startup company with that aim. All other authors declare no competing financial interests.

  • This work was supported by the Agence Nationale de la Recherche Grant ANR-16-CE16-0003-NeuroprOtx.

Funding

  • Agence Nationale de la Recherche (ANR)

    ANR-16-CE16-0003-NeuroprOtx

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  • You are viewing the most recent version of this article.
  • previous version (September 02, 2021).

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Sep 20213760170
Oct 202174302112
Nov 20212618253
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Total 2021486620361
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Total 202376938234
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May 202469125
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Jul 202418762
Aug 2024686126
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Total 20245311651316
Jan 202558240
Feb 20259121304
Mar 20257108364
Apr 202519529
May 20252398
Total 202524445745
Total73041262946
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eneuro: 8 (5)
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September/October 2021
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Photoreceptor cKO of OTX2 Enhances OTX2 Intercellular Transfer in the Retina and Causes Photophobia
Pasquale Pensieri, Annabelle Mantilleri, Damien Plassard, Takahisa Furukawa, Kenneth L. Moya, Alain Prochiantz, Thomas Lamonerie
eNeuro 2 September 2021, 8 (5) ENEURO.0229-21.2021; DOI: 10.1523/ENEURO.0229-21.2021

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Photoreceptor cKO of OTX2 Enhances OTX2 Intercellular Transfer in the Retina and Causes Photophobia
Pasquale Pensieri, Annabelle Mantilleri, Damien Plassard, Takahisa Furukawa, Kenneth L. Moya, Alain Prochiantz, Thomas Lamonerie
eNeuro 2 September 2021, 8 (5) ENEURO.0229-21.2021; DOI: 10.1523/ENEURO.0229-21.2021
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Keywords

  • arrestin-1
  • homeoprotein transfer
  • mouse
  • Otx2
  • photoreceptors
  • retina

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