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Research ArticleResearch Article: New Research, Disorders of the Nervous System

Single Dose of Amphetamine Induces Delayed Subregional Attenuation of Cholinergic Interneuron Activity in the Striatum

Samira Ztaou, Soo Jung Oh, Sophia Tepler, Sixtine Fleury, Miriam Matamales, Jesus Bertran-Gonzalez, Nao Chuhma and Stephen Rayport
eNeuro 30 August 2021, 8 (5) ENEURO.0196-21.2021; https://doi.org/10.1523/ENEURO.0196-21.2021
Samira Ztaou
1Department of Molecular Therapeutics, New York State Psychiatric Institute, New York, NY 10032
2Department of Psychiatry, Columbia University, New York, NY 10032
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  • ORCID record for Samira Ztaou
Soo Jung Oh
1Department of Molecular Therapeutics, New York State Psychiatric Institute, New York, NY 10032
2Department of Psychiatry, Columbia University, New York, NY 10032
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Sophia Tepler
1Department of Molecular Therapeutics, New York State Psychiatric Institute, New York, NY 10032
2Department of Psychiatry, Columbia University, New York, NY 10032
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Sixtine Fleury
1Department of Molecular Therapeutics, New York State Psychiatric Institute, New York, NY 10032
2Department of Psychiatry, Columbia University, New York, NY 10032
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Miriam Matamales
3Decision Neuroscience Laboratory, School of Psychology, University of New South Wales, Sydney, NSW 2052, Australia
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Jesus Bertran-Gonzalez
3Decision Neuroscience Laboratory, School of Psychology, University of New South Wales, Sydney, NSW 2052, Australia
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Nao Chuhma
1Department of Molecular Therapeutics, New York State Psychiatric Institute, New York, NY 10032
2Department of Psychiatry, Columbia University, New York, NY 10032
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Stephen Rayport
1Department of Molecular Therapeutics, New York State Psychiatric Institute, New York, NY 10032
2Department of Psychiatry, Columbia University, New York, NY 10032
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0196-21.2021
PubMed 
34462310
Published By 
Society for Neuroscience
History 
  • Received May 3, 2021
  • Revision received August 9, 2021
  • Accepted August 23, 2021
  • Published online August 30, 2021.
Copyright & Usage 
Copyright © 2021 Ztaou et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Samira Ztaou1,2,
  2. Soo Jung Oh1,2,
  3. Sophia Tepler1,2,
  4. Sixtine Fleury1,2,
  5. Miriam Matamales3,
  6. Jesus Bertran-Gonzalez3,
  7. Nao Chuhma1,2 and
  8. Stephen Rayport1,2
  1. 1Department of Molecular Therapeutics, New York State Psychiatric Institute, New York, NY 10032
  2. 2Department of Psychiatry, Columbia University, New York, NY 10032
  3. 3Decision Neuroscience Laboratory, School of Psychology, University of New South Wales, Sydney, NSW 2052, Australia
  1. Correspondence should be addressed to Samira Ztaou at samira.ztaou{at}nyspi.columbia.edu or Stephen Rayport at stephen.rayport{at}nyspi.columbia.edu.
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Author contributions

  1. Author contributions: S.Z. and S.R. designed research; S.Z., S.J.O., S.T., and S.F. performed research; S.Z., M.M., and J.B.-G. analyzed data; S.Z., N.C., and S.R. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by National Institutes of Health Grants R01 DA038966 and R01 MH117128 (to S.R.), Philippe Foundation (to S.Z.), Australian Research Council Grants DP190102511 and DP210102700, and National Health and Medical Research Council Grants APP1165990 (to J.B.-G. and M.M.) and FT200100502 (to J.B.-G.).

Funding

  • HHS | NIH | National Institute on Drug Abuse (NIDA)

    NIH R01 DA038966
  • HHS | NIH | National Institute of Mental Health (NIMH)

    NIH R01 MH117128
  • Australian Research Council (ARC)

    ARC DP190102511; ARC DP210102700; FT200100502
  • Department of Health | National Health and Medical Research Council (NHMRC)

    NHMRC APP1165990

Other Version

  • You are viewing the most recent version of this article.
  • previous version (August 30, 2021).

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Article usage: August 2021 to January 2026

AbstractFullPdf
Aug 20213205
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Oct 20216940886
Nov 20212313731
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Total 2021376812273
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Apr 202226413
May 202239425
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Jul 202247612
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Total 202271806181
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Jul 202379013
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Apr 202468713
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Total 2024351073140
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Feb 2025611611
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Apr 202549634
May 2025211213
Jun 2025810917
Jul 2025210715
Aug 202549527
Sep 2025814125
Oct 2025811428
Nov 20251513516
Dec 20251122248
Total 2025741445263
Jan 2026119928
Total 2026119928
Total60852061038
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eneuro: 8 (5)
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September/October 2021
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Single Dose of Amphetamine Induces Delayed Subregional Attenuation of Cholinergic Interneuron Activity in the Striatum
Samira Ztaou, Soo Jung Oh, Sophia Tepler, Sixtine Fleury, Miriam Matamales, Jesus Bertran-Gonzalez, Nao Chuhma, Stephen Rayport
eNeuro 30 August 2021, 8 (5) ENEURO.0196-21.2021; DOI: 10.1523/ENEURO.0196-21.2021

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Single Dose of Amphetamine Induces Delayed Subregional Attenuation of Cholinergic Interneuron Activity in the Striatum
Samira Ztaou, Soo Jung Oh, Sophia Tepler, Sixtine Fleury, Miriam Matamales, Jesus Bertran-Gonzalez, Nao Chuhma, Stephen Rayport
eNeuro 30 August 2021, 8 (5) ENEURO.0196-21.2021; DOI: 10.1523/ENEURO.0196-21.2021
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Keywords

  • Acetylcholine
  • dopamine
  • fluorescence imaging
  • phosphorylated ribosomal protein S6
  • psychostimulant

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