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Research ArticleResearch Article: New Research, Sensory and Motor Systems

TMEM16A and TMEM16B Modulate Pheromone-Evoked Action Potential Firing in Mouse Vomeronasal Sensory Neurons

Andres Hernandez-Clavijo, Nicole Sarno, Kevin Y. Gonzalez-Velandia, Rudolf Degen, David Fleck, Jason R. Rock, Marc Spehr, Anna Menini and Simone Pifferi
eNeuro 25 August 2021, 8 (5) ENEURO.0179-21.2021; https://doi.org/10.1523/ENEURO.0179-21.2021
Andres Hernandez-Clavijo
1Neurobiology Group, SISSA, International School for Advanced Studies, Trieste 34136, Italy
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Nicole Sarno
1Neurobiology Group, SISSA, International School for Advanced Studies, Trieste 34136, Italy
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Kevin Y. Gonzalez-Velandia
1Neurobiology Group, SISSA, International School for Advanced Studies, Trieste 34136, Italy
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Rudolf Degen
2Department of Chemosensation, Institute for Biology II, RWTH Aachen University, Aachen D-52074, Germany
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David Fleck
2Department of Chemosensation, Institute for Biology II, RWTH Aachen University, Aachen D-52074, Germany
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Jason R. Rock
3Center for Regenerative Medicine, Boston University School of Medicine, Boston 02118, MA
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Marc Spehr
2Department of Chemosensation, Institute for Biology II, RWTH Aachen University, Aachen D-52074, Germany
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Anna Menini
1Neurobiology Group, SISSA, International School for Advanced Studies, Trieste 34136, Italy
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Simone Pifferi
1Neurobiology Group, SISSA, International School for Advanced Studies, Trieste 34136, Italy
4Department of Experimental and Clinical Medicine, Università Politecnica delle Marche, Ancona 60126, Italy
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0179-21.2021
PubMed 
34433575
Published By 
Society for Neuroscience
History 
  • Received April 22, 2021
  • Revision received June 21, 2021
  • Accepted July 6, 2021
  • Published online August 25, 2021.
Copyright & Usage 
Copyright © 2021 Hernandez-Clavijo et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Andres Hernandez-Clavijo1,
  2. Nicole Sarno1,
  3. Kevin Y. Gonzalez-Velandia1,
  4. Rudolf Degen2,
  5. David Fleck2,
  6. Jason R. Rock3,
  7. Marc Spehr2,
  8. Anna Menini1 and
  9. Simone Pifferi1,4
  1. 1Neurobiology Group, SISSA, International School for Advanced Studies, Trieste 34136, Italy
  2. 2Department of Chemosensation, Institute for Biology II, RWTH Aachen University, Aachen D-52074, Germany
  3. 3Center for Regenerative Medicine, Boston University School of Medicine, Boston 02118, MA
  4. 4Department of Experimental and Clinical Medicine, Università Politecnica delle Marche, Ancona 60126, Italy
  1. Correspondence should be addressed to Anna Menini at menini{at}sissa.it or Marc Spehr at m.spehr{at}sensorik.rwth-aachen.de.
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Author contributions

  1. Author contributions: A.H.-C., N.S., K.Y.G.-V., R.D., D.F., M.S., A.M., and S.P. designed research; A.H.-C., N.S., K.Y.G.-V., R.D., and D.F. performed research; J.R.R. contributed unpublished reagents/analytic tools; A.H.-C., N.S., K.Y.G.-V., R.D., D.F., M.S., A.M., and S.P. analyzed data; A.H.-C., N.S., R.D., M.S., A.M., and S.P. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by Deutsche Forschungsgemeinschaft (DFG; German Research Foundation) Grants 368482240/GRK2416 (to R.D. and M.S.) and the German Academic Scholarship Foundation (to R.D.).

Funding

  • Deutsche Forschungsgemeinschaft (DFG)

    368482240/GRK2416; 378028035

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TMEM16A and TMEM16B Modulate Pheromone-Evoked Action Potential Firing in Mouse Vomeronasal Sensory Neurons
Andres Hernandez-Clavijo, Nicole Sarno, Kevin Y. Gonzalez-Velandia, Rudolf Degen, David Fleck, Jason R. Rock, Marc Spehr, Anna Menini, Simone Pifferi
eNeuro 25 August 2021, 8 (5) ENEURO.0179-21.2021; DOI: 10.1523/ENEURO.0179-21.2021

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TMEM16A and TMEM16B Modulate Pheromone-Evoked Action Potential Firing in Mouse Vomeronasal Sensory Neurons
Andres Hernandez-Clavijo, Nicole Sarno, Kevin Y. Gonzalez-Velandia, Rudolf Degen, David Fleck, Jason R. Rock, Marc Spehr, Anna Menini, Simone Pifferi
eNeuro 25 August 2021, 8 (5) ENEURO.0179-21.2021; DOI: 10.1523/ENEURO.0179-21.2021
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Keywords

  • ion channel
  • sensory
  • TMEM16
  • vomeronasal

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