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Research ArticleResearch Article: New Research, Disorders of the Nervous System

Protein Nanoparticles Modified with PDGF-B as a Novel Therapy After Acute Cerebral Infarction

Soh Takagishi, Koichi Arimura, Masaharu Murata, Katsuma Iwaki, Tomohiro Okuda, Keisuke Ido, Ataru Nishimura, Sayoko Narahara, Takahito Kawano and Koji Iihara
eNeuro 30 August 2021, 8 (5) ENEURO.0098-21.2021; DOI: https://doi.org/10.1523/ENEURO.0098-21.2021
Soh Takagishi
1Department of Neurosurgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan
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  • ORCID record for Soh Takagishi
Koichi Arimura
1Department of Neurosurgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan
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Masaharu Murata
2Center for Advanced Medical Innovation, Kyushu University, Fukuoka 812-8582, Japan
3Department of Advanced Medical Initiatives, Faculty of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan
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Katsuma Iwaki
1Department of Neurosurgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan
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Tomohiro Okuda
1Department of Neurosurgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan
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Keisuke Ido
1Department of Neurosurgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan
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Ataru Nishimura
1Department of Neurosurgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan
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Sayoko Narahara
2Center for Advanced Medical Innovation, Kyushu University, Fukuoka 812-8582, Japan
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Takahito Kawano
2Center for Advanced Medical Innovation, Kyushu University, Fukuoka 812-8582, Japan
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Koji Iihara
1Department of Neurosurgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan
4National Cerebral and Cardiovascular Center, Suita, Japan, Osaka 564-8565, Japan
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0098-21.2021
PubMed 
34462309
Published By 
Society for Neuroscience
History 
  • Received March 4, 2021
  • Revision received August 18, 2021
  • Accepted August 21, 2021
  • Published online August 30, 2021.
Copyright & Usage 
Copyright © 2021 Takagishi et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Soh Takagishi1,
  2. Koichi Arimura1,
  3. Masaharu Murata2,3,
  4. Katsuma Iwaki1,
  5. Tomohiro Okuda1,
  6. Keisuke Ido1,
  7. Ataru Nishimura1,
  8. Sayoko Narahara2,
  9. Takahito Kawano2 and
  10. Koji Iihara1,4
  1. 1Department of Neurosurgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan
  2. 2Center for Advanced Medical Innovation, Kyushu University, Fukuoka 812-8582, Japan
  3. 3Department of Advanced Medical Initiatives, Faculty of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan
  4. 4National Cerebral and Cardiovascular Center, Suita, Japan, Osaka 564-8565, Japan
  1. Correspondence should be addressed to Koichi Arimura at arimura.koichi.001{at}m.kyushu-u.ac.jp.
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Author contributions

  1. Author contributions: S.T., K.A., M.M., A.N., and K.Ii. designed research; S.T., K.Iw., T.O., K.Id., and S.N. performed research; S.T., K.Iw., S.N., and T.K. analyzed data; S.T., K.A., and T.K. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by from the Ministry of Education, Culture, Sports, Science and Technology of Japan Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research (KAKENHI) 18K16588 (to K.A.), 18K12079 (to T.K.), and 19H04470 (to M.M.) and by a Bristol Myers Squibb Research grant (K.A.).

Funding

  • JSPS KAKENHI

    18K16588; 18K12079; 19H04470
  • Bristol-Myers Squibb (BMS)

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  • You are viewing the most recent version of this article.
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Protein Nanoparticles Modified with PDGF-B as a Novel Therapy After Acute Cerebral Infarction
Soh Takagishi, Koichi Arimura, Masaharu Murata, Katsuma Iwaki, Tomohiro Okuda, Keisuke Ido, Ataru Nishimura, Sayoko Narahara, Takahito Kawano, Koji Iihara
eNeuro 30 August 2021, 8 (5) ENEURO.0098-21.2021; DOI: 10.1523/ENEURO.0098-21.2021

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Protein Nanoparticles Modified with PDGF-B as a Novel Therapy After Acute Cerebral Infarction
Soh Takagishi, Koichi Arimura, Masaharu Murata, Katsuma Iwaki, Tomohiro Okuda, Keisuke Ido, Ataru Nishimura, Sayoko Narahara, Takahito Kawano, Koji Iihara
eNeuro 30 August 2021, 8 (5) ENEURO.0098-21.2021; DOI: 10.1523/ENEURO.0098-21.2021
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Keywords

  • cerebral infarction
  • nanoparticle
  • neuroprotection
  • pericyte
  • platelet-derived growth factor PDGF-B

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