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Research ArticleResearch Article: New Research, Disorders of the Nervous System

Modeling Neurodevelopmental Disorders and Epilepsy Caused by Loss of Function of kif2a in Zebrafish

Michèle Partoens, Ann-Sofie De Meulemeester, Hoi-Khoanh Giong, Duc-Hung Pham, Jeong-Soo Lee, Peter A. de Witte and Aleksandra Siekierska
eNeuro 17 August 2021, 8 (5) ENEURO.0055-21.2021; https://doi.org/10.1523/ENEURO.0055-21.2021
Michèle Partoens
1Laboratory for Molecular Biodiscovery, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, 3000 Leuven, Belgium
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Ann-Sofie De Meulemeester
1Laboratory for Molecular Biodiscovery, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, 3000 Leuven, Belgium
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  • ORCID record for Ann-Sofie De Meulemeester
Hoi-Khoanh Giong
2Disease Target Structure Research Centre, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Republic of Korea
3KRIBB School, University of Science and Technology, Daejeon 34141, Republic of Korea
4Dementia DTC R&D Convergence Program, Korea Institute of Science and Technology, Seoul 02792, Republic of Korea
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Duc-Hung Pham
1Laboratory for Molecular Biodiscovery, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, 3000 Leuven, Belgium
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Jeong-Soo Lee
2Disease Target Structure Research Centre, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Republic of Korea
3KRIBB School, University of Science and Technology, Daejeon 34141, Republic of Korea
4Dementia DTC R&D Convergence Program, Korea Institute of Science and Technology, Seoul 02792, Republic of Korea
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Peter A. de Witte
1Laboratory for Molecular Biodiscovery, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, 3000 Leuven, Belgium
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Aleksandra Siekierska
1Laboratory for Molecular Biodiscovery, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, 3000 Leuven, Belgium
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  • ORCID record for Aleksandra Siekierska
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0055-21.2021
PubMed 
34404749
Published By 
Society for Neuroscience
History 
  • Received February 9, 2021
  • Revision received July 23, 2021
  • Accepted August 3, 2021
  • Published online August 17, 2021.
Copyright & Usage 
Copyright © 2021 Partoens et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Michèle Partoens1,
  2. Ann-Sofie De Meulemeester1,
  3. Hoi-Khoanh Giong2,3,4,
  4. Duc-Hung Pham1,
  5. Jeong-Soo Lee2,3,4,
  6. Peter A. de Witte1 and
  7. Aleksandra Siekierska1
  1. 1Laboratory for Molecular Biodiscovery, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, 3000 Leuven, Belgium
  2. 2Disease Target Structure Research Centre, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Republic of Korea
  3. 3KRIBB School, University of Science and Technology, Daejeon 34141, Republic of Korea
  4. 4Dementia DTC R&D Convergence Program, Korea Institute of Science and Technology, Seoul 02792, Republic of Korea
  1. Correspondence should be addressed to Peter A. de Witte at peter.dewitte{at}kuleuven.be.
  • D.-H. Pham’s present address: Division of Immunobiology, Cincinnati Children’s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229.

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Author contributions

  1. Author contributions: M.P., P.A.d.W., and A.S. designed research; M.P., A.-S.D.M., H.-K.G., D.-H.P., and J.-S.L. performed research; M.P., A.-S.D.M., H.-K.G., D.-H.P., J.-S.L., and A.S. analyzed data; M.P., P.A.d.W., and A.S. wrote the paper.

  • D.-H. Pham’s present address: Division of Immunobiology, Cincinnati Children’s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229.

Disclosures

  • The authors declare no competing financial interests.

  • This study received funding from the Scientific Research Foundation Flanders (FWO). M.P. is a PhD fellow of the Fund for Research Foundation Flanders (FWO, Grant 1S84418N) and A.-S.D.M. is a PhD fellow of the Fund for O6260 Research Foundation Flanders (FWO, Grant 11F2919N). J.-S.L. was supported by the National Research Council of Science & Technology of the Ministry of Science and ICT of Korea (Grant CRC-15-04-KIST) and the KRIBB Research Initiative Program. A.S. was supported by KU Leuven Internal Funding C3 (Grant C32/18/067). The Cell and Tissue Imaging Cluster at KU Leuven was supported by Hercules Grant AKUL/11/37 and FWO Grant G.0929.15.

Funding

  • Fonds Wetenschappelijk Onderzoek (FWO)

    1S84418N; 11F2919N
  • Korea Institute of Science and Technology (KIST)

    CRC-15-04-KIST
  • KU Leuven (Katholieke Universiteit Leuven)

    C32/18/067

Other Version

  • You are viewing the most recent version of this article.
  • previous version (August 17, 2021).

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Article usage: August 2021 to March 2026

AbstractFullPdf
Aug 20212330120
Sep 2021210494141
Oct 20214837198
Nov 20213314944
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Total 20215391172444
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Mar 2022129842
Apr 2022148534
May 2022615267
Jun 2022411631
Jul 2022410823
Aug 202278133
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Total 2022821117394
Jan 202326415
Feb 202305913
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Apr 20234889
May 202306917
Jun 2023137712
Jul 202337617
Aug 202387023
Sep 202348525
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Total 202355950214
Jan 202499714
Feb 202429724
Mar 202489829
Apr 2024119933
May 2024510225
Jun 2024108018
Jul 202479121
Aug 2024138530
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Total 2024881070234
Jan 2025109020
Feb 2025111223
Mar 2025610633
Apr 2025611432
May 2025610530
Jun 2025610015
Jul 20251212936
Aug 2025510023
Sep 20251515820
Oct 20251213326
Nov 2025712513
Dec 2025914842
Total 2025951420313
Jan 20261013516
Feb 2026918529
Mar 20264230
Total 20262334345
Total88260721644
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Modeling Neurodevelopmental Disorders and Epilepsy Caused by Loss of Function of kif2a in Zebrafish
Michèle Partoens, Ann-Sofie De Meulemeester, Hoi-Khoanh Giong, Duc-Hung Pham, Jeong-Soo Lee, Peter A. de Witte, Aleksandra Siekierska
eNeuro 17 August 2021, 8 (5) ENEURO.0055-21.2021; DOI: 10.1523/ENEURO.0055-21.2021

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Modeling Neurodevelopmental Disorders and Epilepsy Caused by Loss of Function of kif2a in Zebrafish
Michèle Partoens, Ann-Sofie De Meulemeester, Hoi-Khoanh Giong, Duc-Hung Pham, Jeong-Soo Lee, Peter A. de Witte, Aleksandra Siekierska
eNeuro 17 August 2021, 8 (5) ENEURO.0055-21.2021; DOI: 10.1523/ENEURO.0055-21.2021
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Keywords

  • drug-resistant epilepsy
  • KIF2A
  • malformations of cortical development
  • seizures
  • zebrafish

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