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Research ArticleResearch Article: New Research, Disorders of the Nervous System

Seizure Phenotype and Underlying Cellular Defects in Drosophila Knock-In Models of DS (R1648C) and GEFS+ (R1648H) SCN1A Epilepsy

Alexa Joanna Roemmich, Thy Vu, Tamas Lukacsovich, Charlesice Hawkins, Soleil S. Schutte and Diane K. O’Dowd
eNeuro 2 September 2021, 8 (5) ENEURO.0002-21.2021; https://doi.org/10.1523/ENEURO.0002-21.2021
Alexa Joanna Roemmich
1Department of Developmental and Cell Biology, University of California, Irvine, Irvine, California 92697
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Thy Vu
1Department of Developmental and Cell Biology, University of California, Irvine, Irvine, California 92697
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Tamas Lukacsovich
2Faculties of Medicine and Natural Sciences, Brain Research Institute, University of Zürich, CH-8057 Zürich, Switzerland
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Charlesice Hawkins
3Office of Intramural Training and Education, National Institutes of Health, Bethesda, Maryland 20892
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Soleil S. Schutte
4Department of Anesthesiology, University of Florida, Gainesville, Florida 32610
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Diane K. O’Dowd
1Department of Developmental and Cell Biology, University of California, Irvine, Irvine, California 92697
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0002-21.2021
PubMed 
34475263
Published By 
Society for Neuroscience
History 
  • Received January 1, 2021
  • Revision received August 5, 2021
  • Accepted August 14, 2021
  • Published online September 2, 2021.
Copyright & Usage 
Copyright © 2021 Roemmich et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Alexa Joanna Roemmich1,
  2. Thy Vu1,
  3. Tamas Lukacsovich2,
  4. Charlesice Hawkins3,
  5. Soleil S. Schutte4 and
  6. Diane K. O’Dowd1
  1. 1Department of Developmental and Cell Biology, University of California, Irvine, Irvine, California 92697
  2. 2Faculties of Medicine and Natural Sciences, Brain Research Institute, University of Zürich, CH-8057 Zürich, Switzerland
  3. 3Office of Intramural Training and Education, National Institutes of Health, Bethesda, Maryland 20892
  4. 4Department of Anesthesiology, University of Florida, Gainesville, Florida 32610
  1. Correspondence should be addressed to Diane K. O’Dowd at dkodowd{at}uci.edu.
View Full Text

Author contributions

  1. Author contributions: A.J.R., T.L., S.S.S., and D.K.O. designed research; A.J.R., T.V., and C.H. performed research; A.J.R. and T.V. analyzed data; A.J.R., S.S.S., and D.K.O. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by the National Institutes of Health Grant R01-NS-083009 (D.K.O.), the Graduate Assistant in Areas of National Need Grant P200A120207, and a Graduate Dean’s Dissertation Fellowship, Graduate Division, University of California, Irvine (to A.J.R).

Funding

  • HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS)

    R01NS083009
  • Dept. of Ed. Graduate Assistance in Areas of National Need

    P200A120207
  • Graduate Dean’s Dissertation Fellowship, Graduate Division, University of California Irvine

Other Version

  • You are viewing the most recent version of this article.
  • previous version (September 02, 2021).

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Article usage: September 2021 to March 2026

AbstractFullPdf
Sep 2021430250188
Oct 20216233486
Nov 20212615333
Dec 20211923723
Total 2021537974330
Jan 20221111317
Feb 202296417
Mar 2022108120
Apr 202256818
May 202249621
Jun 202259520
Jul 202237413
Aug 202269120
Sep 202267225
Oct 202256922
Nov 202255480
Dec 202205516
Total 202269932289
Jan 20231757
Feb 202317912
Mar 20231789
Apr 202338916
May 20233708
Jun 20232807
Jul 202318916
Aug 202358423
Sep 2023148921
Oct 202379311
Nov 202368750
Dec 202369719
Total 2023501010199
Jan 2024171009
Feb 2024710327
Mar 20241512028
Apr 20241217625
May 202439320
Jun 202449321
Jul 202449735
Aug 202449314
Sep 202439312
Oct 202429916
Nov 2024410717
Dec 20241010426
Total 2024851278250
Jan 2025714441
Feb 2025315414
Mar 2025816419
Apr 2025421025
May 2025221118
Jun 20251315419
Jul 2025716039
Aug 2025716526
Sep 20251422739
Oct 20251121050
Nov 20252033770
Dec 20251124639
Total 20251072382399
Jan 20261323728
Feb 20261024721
Mar 202661029
Total 20262958658
Total87771621525
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Seizure Phenotype and Underlying Cellular Defects in Drosophila Knock-In Models of DS (R1648C) and GEFS+ (R1648H) SCN1A Epilepsy
Alexa Joanna Roemmich, Thy Vu, Tamas Lukacsovich, Charlesice Hawkins, Soleil S. Schutte, Diane K. O’Dowd
eNeuro 2 September 2021, 8 (5) ENEURO.0002-21.2021; DOI: 10.1523/ENEURO.0002-21.2021

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Seizure Phenotype and Underlying Cellular Defects in Drosophila Knock-In Models of DS (R1648C) and GEFS+ (R1648H) SCN1A Epilepsy
Alexa Joanna Roemmich, Thy Vu, Tamas Lukacsovich, Charlesice Hawkins, Soleil S. Schutte, Diane K. O’Dowd
eNeuro 2 September 2021, 8 (5) ENEURO.0002-21.2021; DOI: 10.1523/ENEURO.0002-21.2021
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Keywords

  • Drosophila
  • electrophysiology
  • epilepsy
  • Scn1a
  • sodium channel

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