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Research ArticleOpen Source Tools and Methods, Novel Tools and Methods

MyelTracer: A Semi-Automated Software for Myelin g-Ratio Quantification

Tobias Kaiser, Harrison Mitchell Allen, Ohyoon Kwon, Boaz Barak, Jing Wang, Zhigang He, Minqing Jiang and Guoping Feng
eNeuro 30 June 2021, 8 (4) ENEURO.0558-20.2021; https://doi.org/10.1523/ENEURO.0558-20.2021
Tobias Kaiser
1McGovern Institute for Brain Research, Cambridge, MA 02139
2Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139
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Harrison Mitchell Allen
1McGovern Institute for Brain Research, Cambridge, MA 02139
3Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA 02139
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Ohyoon Kwon
1McGovern Institute for Brain Research, Cambridge, MA 02139
2Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139
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Boaz Barak
4The Sagol School of Neuroscience and The School of Psychological Sciences, Tel Aviv University, Tel Aviv, 6997801, Israel
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Jing Wang
5F.M. Kirby Neurobiology Center, Boston Children’s Hospital, and Department of Neurology and Ophthalmology, Harvard Medical School, Boston, MA 02115
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Zhigang He
5F.M. Kirby Neurobiology Center, Boston Children’s Hospital, and Department of Neurology and Ophthalmology, Harvard Medical School, Boston, MA 02115
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Minqing Jiang
1McGovern Institute for Brain Research, Cambridge, MA 02139
2Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139
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Guoping Feng
1McGovern Institute for Brain Research, Cambridge, MA 02139
2Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139
6Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0558-20.2021
PubMed 
34193510
Published By 
Society for Neuroscience
History 
  • Received December 23, 2020
  • Revision received June 14, 2021
  • Accepted June 17, 2021
  • Published online June 30, 2021.
Copyright & Usage 
Copyright © 2021 Kaiser et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Tobias Kaiser1,2,*,
  2. Harrison Mitchell Allen1,3,*,
  3. Ohyoon Kwon1,2,*,
  4. Boaz Barak4,
  5. Jing Wang5,
  6. Zhigang He5,
  7. Minqing Jiang1,2 and
  8. Guoping Feng1,2,6
  1. 1McGovern Institute for Brain Research, Cambridge, MA 02139
  2. 2Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139
  3. 3Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA 02139
  4. 4The Sagol School of Neuroscience and The School of Psychological Sciences, Tel Aviv University, Tel Aviv, 6997801, Israel
  5. 5F.M. Kirby Neurobiology Center, Boston Children’s Hospital, and Department of Neurology and Ophthalmology, Harvard Medical School, Boston, MA 02115
  6. 6Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142
  1. Correspondence should be addressed to Minqing Jiang at minqing{at}mit.edu or Guoping Feng at fengg{at}mit.edu.
View Full Text

Author contributions

  1. Author contributions: T.K., H.M.A., M.J., and G.F. designed the research. H.M.A. wrote the software; T.K. and M.J. generated the electron microscopy data; T.K., M.J., and O.K. analyzed the data and benchmarked the software. B.B., J.W., and Z.H. contributed electron micrographs for additional analysis. T.K., M.J., and G.F. wrote the paper with inputs from all authors.

  2. ↵* T.K., H.A., and O.K. contributed equally to this work.

Disclosures

  • The authors declare no competing financial interests.

  • T.K. is supported by the Tan-Yang center for Autism Research at MIT. G.F. is supported by the National Institute of Mental Health Grant 5R01MH097104, the Poitras Center for Affective Disorders Research at MIT, Tan-Yang Center for Autism Research at MIT, Stanley Center for Psychiatric Research at Broad Institute of MIT and Harvard, Nancy Lurie Marks Family Foundation, Simons Foundation Autism Research Initiative (SFARI), and Simons Center for the Social Brain at MIT.

Funding

  • Tan-Yang Center for Autism Research at MIT

  • Simons Foundation

  • Simons Center for the Social Brain at MIT

  • HHS | NIH | National Institute of Mental Health (NIMH)

    R01MH097104
  • Poitras Center for Affective Disorders Research at MIT

  • Stanley Center for Psychiatric Research at the Broad Institute of MIT and Harvard

  • Nancy Lurie Marks Family Foundation (NLMFF)

Other Version

  • You are viewing the most recent version of this article.
  • previous version (June 30, 2021).

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AbstractFullPdf
Jun 20213009
Jul 2021874235355
Aug 2021135497135
Sep 20211925562
Oct 20212626187
Nov 20211620958
Dec 20211917756
Total 202111191634762
Jan 20221823876
Feb 20224628767
Mar 20224951559
Apr 20224040069
May 20224923182
Jun 20223726281
Jul 20221919858
Aug 20223723474
Sep 20224423653
Oct 20221153480
Nov 20224337104
Dec 2022212146
Total 20223563593849
Jan 2023319177
Feb 2023318862
Mar 2023418763
Apr 2023217348
May 2023219664
Jun 20233266108
Jul 2023526370
Aug 2023422461
Sep 20231721252
Oct 2023624972
Nov 202330265111
Dec 20231124271
Total 2023902656859
Jan 20242226191
Feb 202413243101
Mar 20241322978
Apr 20241418774
May 2024525373
Jun 20241720072
Jul 2024829697
Aug 20241321845
Sep 20241623574
Oct 20241727162
Nov 2024527863
Dec 20241131278
Total 20241542983908
Jan 2025625683
Feb 2025827386
Mar 2025830399
Apr 202515296174
May 20251032372
Jun 20251818832
Total 2025651639546
Total1784125053924
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MyelTracer: A Semi-Automated Software for Myelin g-Ratio Quantification
Tobias Kaiser, Harrison Mitchell Allen, Ohyoon Kwon, Boaz Barak, Jing Wang, Zhigang He, Minqing Jiang, Guoping Feng
eNeuro 30 June 2021, 8 (4) ENEURO.0558-20.2021; DOI: 10.1523/ENEURO.0558-20.2021

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MyelTracer: A Semi-Automated Software for Myelin g-Ratio Quantification
Tobias Kaiser, Harrison Mitchell Allen, Ohyoon Kwon, Boaz Barak, Jing Wang, Zhigang He, Minqing Jiang, Guoping Feng
eNeuro 30 June 2021, 8 (4) ENEURO.0558-20.2021; DOI: 10.1523/ENEURO.0558-20.2021
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Keywords

  • electron microscopy
  • g-ratio
  • myelin
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