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Research ArticleResearch Article: New Research, Sensory and Motor Systems

Neural Dynamics in Primate Cortex during Exposure to Subanesthetic Concentrations of Nitrous Oxide

Matthew S. Willsey, Chrono S. Nu, Samuel R. Nason, Karen E. Schroeder, Brianna C. Hutchison, Elissa J. Welle, Parag G. Patil, George A. Mashour and Cynthia A. Chestek
eNeuro 16 June 2021, 8 (4) ENEURO.0479-20.2021; https://doi.org/10.1523/ENEURO.0479-20.2021
Matthew S. Willsey
1Department of Neurosurgery, University of Michigan, Ann Arbor, Michigan 48109
2Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan 48109
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  • ORCID record for Matthew S. Willsey
Chrono S. Nu
2Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan 48109
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Samuel R. Nason
2Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan 48109
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Karen E. Schroeder
3Department of Neuroscience, Columbia University, New York, New York 10027
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Brianna C. Hutchison
2Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan 48109
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Elissa J. Welle
2Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan 48109
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Parag G. Patil
1Department of Neurosurgery, University of Michigan, Ann Arbor, Michigan 48109
2Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan 48109
4Neuroscience Graduate Program, University of Michigan Medical School, Ann Arbor, Michigan 48109
5Department of Anesthesiology, University of Michigan, Ann Arbor, Michigan 48109
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George A. Mashour
1Department of Neurosurgery, University of Michigan, Ann Arbor, Michigan 48109
4Neuroscience Graduate Program, University of Michigan Medical School, Ann Arbor, Michigan 48109
5Department of Anesthesiology, University of Michigan, Ann Arbor, Michigan 48109
6Center for Consciousness Studies, University of Michigan, Ann Arbor, Michigan 48109
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Cynthia A. Chestek
2Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan 48109
4Neuroscience Graduate Program, University of Michigan Medical School, Ann Arbor, Michigan 48109
6Center for Consciousness Studies, University of Michigan, Ann Arbor, Michigan 48109
7Department of Electrical Engineering and Computer Science, University of Michigan, Ann Arbor, Michigan 48109
8Robotics Graduate Program, University of Michigan, Ann Arbor, Michigan 48109
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0479-20.2021
PubMed 
34135005
Published By 
Society for Neuroscience
History 
  • Received November 4, 2020
  • Revision received May 7, 2021
  • Accepted May 31, 2021
  • Published online June 16, 2021.
Copyright & Usage 
Copyright © 2021 Willsey et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Matthew S. Willsey1,2,*,
  2. Chrono S. Nu2,*,
  3. Samuel R. Nason2,
  4. Karen E. Schroeder3,
  5. Brianna C. Hutchison2,
  6. Elissa J. Welle2,
  7. Parag G. Patil1,2,4,5,
  8. George A. Mashour1,4,5,6,* and
  9. Cynthia A. Chestek2,4,6,7,8,*
  1. 1Department of Neurosurgery, University of Michigan, Ann Arbor, Michigan 48109
  2. 2Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan 48109
  3. 3Department of Neuroscience, Columbia University, New York, New York 10027
  4. 4Neuroscience Graduate Program, University of Michigan Medical School, Ann Arbor, Michigan 48109
  5. 5Department of Anesthesiology, University of Michigan, Ann Arbor, Michigan 48109
  6. 6Center for Consciousness Studies, University of Michigan, Ann Arbor, Michigan 48109
  7. 7Department of Electrical Engineering and Computer Science, University of Michigan, Ann Arbor, Michigan 48109
  8. 8Robotics Graduate Program, University of Michigan, Ann Arbor, Michigan 48109
  1. Correspondence should be addressed to George A. Mashour at gmashour{at}umich.edu or Cynthia A. Chestek at cchestek{at}umich.edu.
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Author contributions

  1. Author contributions: M.S.W., C.S.N., S.R.N., K.E.S., P.G.P., G.A.M., and C.A.C. designed research; M.S.W., C.S.N., S.R.N., B.C.H., E.J.W., P.G.P., and C.A.C. performed research; M.S.W., C.S.N., S.R.N., and K.E.S. contributed unpublished reagents/analytic tools; M.S.W., C.S.N., G.A.M., and C.A.C. analyzed data; M.S.W., G.A.M., and C.A.C. wrote the paper.

  2. ↵* M.S.W., C.S.N., G.A.M., and C.A.C. contributed equally to this work.

Disclosures

  • The authors declare no competing financial interests.

  • This work was funded by National Institutes of Health (NIH) Grant R01-GM-111293. M.S.W. was partially supported by NIH Grant T32-NS-007222. P.G.P. was supported by the A. Alfred Taubman Medical Research Institute.

Funding

  • HHS | National Institutes of Health (NIH)

    T32 NS007222; R01GM111293
  • A Alfred Taubman Medical Research Institute

Other Version

  • You are viewing the most recent version of this article.
  • previous version (June 16, 2021).

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Article usage: June 2021 to April 2026

AbstractFullPdf
Jun 20212370131
Jul 2021174256107
Aug 20215635272
Sep 20212616839
Oct 20211314543
Nov 2021511251
Dec 202199847
Total 20215201131490
Jan 202217717
Feb 2022415835
Mar 202254796
Apr 2022339916
May 202237716
Jun 202218018
Jul 202224010
Aug 20224428
Sep 202225514
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Total 2022291895181
Jan 202326112
Feb 20234635
Mar 20231627
Apr 20232663
May 20230543
Jun 20230668
Jul 20233686
Aug 202316722
Sep 202347315
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Total 202319818111
Jan 20246658
Feb 20244678
Mar 202447710
Apr 202448318
May 202457912
Jun 20245737
Jul 202447413
Aug 20245689
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Total 202458867113
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Feb 202576910
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May 202519210
Jun 20257828
Jul 202539115
Aug 20253886
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Total 2025731112138
Jan 20261315329
Feb 202651726
Mar 20261017934
Apr 202666729
Total 20263457198
Total73363941131
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Neural Dynamics in Primate Cortex during Exposure to Subanesthetic Concentrations of Nitrous Oxide
Matthew S. Willsey, Chrono S. Nu, Samuel R. Nason, Karen E. Schroeder, Brianna C. Hutchison, Elissa J. Welle, Parag G. Patil, George A. Mashour, Cynthia A. Chestek
eNeuro 16 June 2021, 8 (4) ENEURO.0479-20.2021; DOI: 10.1523/ENEURO.0479-20.2021

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Neural Dynamics in Primate Cortex during Exposure to Subanesthetic Concentrations of Nitrous Oxide
Matthew S. Willsey, Chrono S. Nu, Samuel R. Nason, Karen E. Schroeder, Brianna C. Hutchison, Elissa J. Welle, Parag G. Patil, George A. Mashour, Cynthia A. Chestek
eNeuro 16 June 2021, 8 (4) ENEURO.0479-20.2021; DOI: 10.1523/ENEURO.0479-20.2021
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Keywords

  • anesthesia
  • consciousness
  • nitrous oxide
  • NMDA antagonist
  • sensorimotor

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