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Research ArticleResearch Article: New Research, Disorders of the Nervous System

Intercellular Adhesion Molecule-1-Induced Posttraumatic Brain Injury Neuropathology in the Prefrontal Cortex and Hippocampus Leads to Sensorimotor Function Deficits and Psychological Stress

Saurav Bhowmick, Anitha Malat, Danielle Caruso, Nizmi Ponery, Veera D’Mello, Christina Finn and P. M. Abdul-Muneer
eNeuro 16 June 2021, 8 (4) ENEURO.0242-21.2021; https://doi.org/10.1523/ENEURO.0242-21.2021
Saurav Bhowmick
1Laboratory of CNS injury and Molecular Therapy, JFK Neuroscience Institute, Hackensack Meridian Health JFK University Medical Center, Edison, NJ 08820
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Anitha Malat
1Laboratory of CNS injury and Molecular Therapy, JFK Neuroscience Institute, Hackensack Meridian Health JFK University Medical Center, Edison, NJ 08820
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Danielle Caruso
1Laboratory of CNS injury and Molecular Therapy, JFK Neuroscience Institute, Hackensack Meridian Health JFK University Medical Center, Edison, NJ 08820
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Nizmi Ponery
1Laboratory of CNS injury and Molecular Therapy, JFK Neuroscience Institute, Hackensack Meridian Health JFK University Medical Center, Edison, NJ 08820
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Veera D’Mello
1Laboratory of CNS injury and Molecular Therapy, JFK Neuroscience Institute, Hackensack Meridian Health JFK University Medical Center, Edison, NJ 08820
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Christina Finn
1Laboratory of CNS injury and Molecular Therapy, JFK Neuroscience Institute, Hackensack Meridian Health JFK University Medical Center, Edison, NJ 08820
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P. M. Abdul-Muneer
1Laboratory of CNS injury and Molecular Therapy, JFK Neuroscience Institute, Hackensack Meridian Health JFK University Medical Center, Edison, NJ 08820
2Department of Neurology, Hackensack Meridian School of Medicine, Nutley, NJ 07110
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0242-21.2021
PubMed 
34135004
Published By 
Society for Neuroscience
History 
  • Received May 29, 2021
  • Accepted June 4, 2021
  • Published online June 16, 2021.
Copyright & Usage 
Copyright © 2021 Bhowmick et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Saurav Bhowmick1,
  2. Anitha Malat1,
  3. Danielle Caruso1,
  4. Nizmi Ponery1,
  5. Veera D’Mello1,
  6. Christina Finn1 and
  7. P. M. Abdul-Muneer1,2
  1. 1Laboratory of CNS injury and Molecular Therapy, JFK Neuroscience Institute, Hackensack Meridian Health JFK University Medical Center, Edison, NJ 08820
  2. 2Department of Neurology, Hackensack Meridian School of Medicine, Nutley, NJ 07110
  1. Correspondence should be addressed to P. M. Abdul-Muneer at mohammed.muneer{at}hmhn.org.
  • D. Caruso’s present address: Environmental and Occupational Health Sciences Institute, 170 Frelinghuysen Road, Piscataway, NJ 08854.

  • C. Finn’s present address: The Center for Plastic Surgery, McLean, VA.

  • V. D’Mello’s present address: Department of Pharmacology, Physiology, and Neuroscience, Rutgers University, 185 South Orange Ave, Newark, NJ 07103.

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Author contributions

  1. Author contributions: P.M.A.-M. designed research; S.B., A.M., D.C., N.P., V.D., and C.F. performed research; S.B. and P.M.A.-M. analyzed data; S.B. and P.M.A.-M. wrote the paper.

  • D. Caruso’s present address: Environmental and Occupational Health Sciences Institute, 170 Frelinghuysen Road, Piscataway, NJ 08854.

  • C. Finn’s present address: The Center for Plastic Surgery, McLean, VA.

  • V. D’Mello’s present address: Department of Pharmacology, Physiology, and Neuroscience, Rutgers University, 185 South Orange Ave, Newark, NJ 07103.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by the New Jersey Commission on Brain Injury Research Grant CBIR19PIL010 and the Neuroscience Institute at JFK Medical Center (P.M.A.-M.).

Funding

  • New Jersey Commission on Brain Injury Research (NJCBIR)

    CBIR19PIL010

Other Version

  • You are viewing the most recent version of this article.
  • previous version (June 16, 2021).

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Article usage: June 2021 to February 2026

AbstractFullPdf
Jun 20215060145
Jul 2021251384150
Aug 202177451109
Sep 20213120964
Oct 20212621882
Nov 2021714249
Dec 20211413863
Total 20219121542662
Jan 20222115152
Feb 2022118632
Mar 2022511141
Apr 202227241
May 2022310839
Jun 202229734
Jul 202227324
Aug 202217321
Sep 202287631
Oct 202267527
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Dec 202223817
Total 2022721030392
Jan 202326327
Feb 202328826
Mar 202329621
Apr 202349318
May 202347623
Jun 202329429
Jul 2023710032
Aug 202379743
Sep 2023810621
Oct 2023112029
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Dec 2023913050
Total 2023531194346
Jan 2024011734
Feb 202469124
Mar 2024411647
Apr 20241214838
May 2024110735
Jun 202429830
Jul 202429528
Aug 202498225
Sep 2024610928
Oct 202449625
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Total 2024521266401
Jan 2025311136
Feb 2025169433
Mar 2025110629
Apr 2025710132
May 202539825
Jun 20251010540
Jul 20251211341
Aug 2025410326
Sep 2025417115
Oct 20251211131
Nov 20251811925
Dec 20251113834
Total 20251011370367
Jan 20261215626
Feb 2026113411
Total 20261329037
Total120366922205
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eneuro: 8 (4)
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Intercellular Adhesion Molecule-1-Induced Posttraumatic Brain Injury Neuropathology in the Prefrontal Cortex and Hippocampus Leads to Sensorimotor Function Deficits and Psychological Stress
Saurav Bhowmick, Anitha Malat, Danielle Caruso, Nizmi Ponery, Veera D’Mello, Christina Finn, P. M. Abdul-Muneer
eNeuro 16 June 2021, 8 (4) ENEURO.0242-21.2021; DOI: 10.1523/ENEURO.0242-21.2021

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Intercellular Adhesion Molecule-1-Induced Posttraumatic Brain Injury Neuropathology in the Prefrontal Cortex and Hippocampus Leads to Sensorimotor Function Deficits and Psychological Stress
Saurav Bhowmick, Anitha Malat, Danielle Caruso, Nizmi Ponery, Veera D’Mello, Christina Finn, P. M. Abdul-Muneer
eNeuro 16 June 2021, 8 (4) ENEURO.0242-21.2021; DOI: 10.1523/ENEURO.0242-21.2021
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Keywords

  • traumatic brain injury
  • ICAM-1 signaling
  • LFA-1 and Mac-1
  • cerebral blood flow
  • neuroinflammation
  • neurodegeneration

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  • Sensory-cell population integrity required to preserve minimal and normal vestibulo-ocular reflexes reveals the critical role of type I hair cells in canal- and otolith-specific functions
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