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Research ArticleResearch Article: Confirmation, Novel Tools and Methods

Localizing Microemboli within the Rodent Brain through Block-Face Imaging and Atlas Registration

Matthew W. McDonald, Matthew S. Jeffers, Melissa Filadelfi, Andrea Vicencio, Gavin Heidenreich, Junzheng Wu and Gergely Silasi
eNeuro 16 July 2021, 8 (4) ENEURO.0216-21.2021; DOI: https://doi.org/10.1523/ENEURO.0216-21.2021
Matthew W. McDonald
Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada
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Matthew S. Jeffers
Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada
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Melissa Filadelfi
Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada
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Andrea Vicencio
Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada
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Gavin Heidenreich
Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada
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Junzheng Wu
Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada
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Gergely Silasi
Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0216-21.2021
PubMed 
34272259
Published By 
Society for Neuroscience
History 
  • Received May 6, 2021
  • Revision received June 27, 2021
  • Accepted July 7, 2021
  • Published online July 16, 2021.
Copyright & Usage 
Copyright © 2021 McDonald et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Matthew W. McDonald,
  2. Matthew S. Jeffers,
  3. Melissa Filadelfi,
  4. Andrea Vicencio,
  5. Gavin Heidenreich,
  6. Junzheng Wu and
  7. Gergely Silasi
  1. Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada
  1. Correspondence should be addressed to Gergely Silasi at gsilasi{at}uottawa.ca.
View Full Text

Author contributions

  1. Author contributions: M.W.M., M.S.J., and G.S. designed research; M.W.M., M.F., A.V., and G.S. performed research; G.H. and J.W. contributed unpublished reagents/analytic tools; M.W.M., M.S.J., and A.V. analyzed data; M.W.M. and G.S. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by the Canadian Institutes of Health Research Grant 427791, the Natural Sciences and Engineering Research Council of Canada Grant 06829, and the Heart and Stroke Foundation of Canada Grant 0026556. M.W.M’s salary was partially supported by the Canadian Vascular Network and the Canadian Consortium on Neurodegeneration and Aging awarded to Dale Corbett.

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Jul 2021227079
Aug 2021325549127
Sep 20213116933
Oct 20212515028
Nov 2021512931
Dec 2021810529
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Jan 202289422
Feb 202256820
Mar 202259119
Apr 2022105920
May 2022410230
Jun 202211069
Jul 202265411
Aug 202247110
Sep 202284115
Oct 202244319
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Total 202259834214
Jan 202315516
Total 202315516
Total6811991557
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eneuro: 8 (4)
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Vol. 8, Issue 4
July/August 2021
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Localizing Microemboli within the Rodent Brain through Block-Face Imaging and Atlas Registration
Matthew W. McDonald, Matthew S. Jeffers, Melissa Filadelfi, Andrea Vicencio, Gavin Heidenreich, Junzheng Wu, Gergely Silasi
eNeuro 16 July 2021, 8 (4) ENEURO.0216-21.2021; DOI: 10.1523/ENEURO.0216-21.2021

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Localizing Microemboli within the Rodent Brain through Block-Face Imaging and Atlas Registration
Matthew W. McDonald, Matthew S. Jeffers, Melissa Filadelfi, Andrea Vicencio, Gavin Heidenreich, Junzheng Wu, Gergely Silasi
eNeuro 16 July 2021, 8 (4) ENEURO.0216-21.2021; DOI: 10.1523/ENEURO.0216-21.2021
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Keywords

  • block-face
  • histology
  • Microinfarcts
  • mouse
  • stroke
  • vascular dementia

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