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Research ArticleResearch Article: New Research, Neuronal Excitability

Electronic Nicotine Vapor Exposure Produces Differential Changes in Central Amygdala Neuronal Activity, Thermoregulation and Locomotor Behavior in Male Mice

M. Zhu, M. Echeveste Sanchez, E. A. Douglass, J. V. Jahad, T. D. Hanback, T. N. Guhr Lee, C. R. Esther Jr., M. Cole, A. J. Roberts and M. A. Herman
eNeuro 28 July 2021, 8 (4) ENEURO.0189-21.2021; https://doi.org/10.1523/ENEURO.0189-21.2021
M. Zhu
1Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599
2Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599
3Neuroscience Curriculum, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599
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M. Echeveste Sanchez
2Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599
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E. A. Douglass
2Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599
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J. V. Jahad
1Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599
2Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599
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T. D. Hanback
2Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599
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T. N. Guhr Lee
4Division of Pediatric Pulmonology, Department of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599
5Marsico Lung Institute/Cystic Fibrosis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599
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C. R. Esther Jr.
4Division of Pediatric Pulmonology, Department of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599
5Marsico Lung Institute/Cystic Fibrosis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599
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M. Cole
6Animal Models Core, The Scripps Research Institute, La Jolla, CA 92037
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A. J. Roberts
6Animal Models Core, The Scripps Research Institute, La Jolla, CA 92037
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M. A. Herman
1Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599
2Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0189-21.2021
PubMed 
34321216
Published By 
Society for Neuroscience
History 
  • Received April 30, 2021
  • Revision received July 19, 2021
  • Accepted July 21, 2021
  • Published online July 28, 2021.
Copyright & Usage 
Copyright © 2021 Zhu et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. M. Zhu1,2,3,
  2. M. Echeveste Sanchez2,
  3. E. A. Douglass2,
  4. J. V. Jahad1,2,
  5. T. D. Hanback2,
  6. T. N. Guhr Lee4,5,
  7. C. R. Esther Jr.4,5,
  8. M. Cole6,
  9. A. J. Roberts6 and
  10. M. A. Herman1,2
  1. 1Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599
  2. 2Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599
  3. 3Neuroscience Curriculum, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599
  4. 4Division of Pediatric Pulmonology, Department of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599
  5. 5Marsico Lung Institute/Cystic Fibrosis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599
  6. 6Animal Models Core, The Scripps Research Institute, La Jolla, CA 92037
  1. Correspondence should be addressed to M. A. Herman at melissa_herman{at}unc.edu.
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Author contributions

  1. Author contributions: M.Z. and M.A.H. designed research; M.Z., M.E.S., E.A.D., J.V.J., T.D.H., T.N.G.L., C.R.E., M.C., A.J.R., and M.A.H. performed research; M.Z., M.E.S., E.A.D., J.V.J., T.D.H., T.N.G.L., C.R.E., M.C., A.J.R., and M.A.H. analyzed data; M.Z., M.E.S., and M.A.H. wrote the paper.

Disclosures

  • M.C. is proprietor of La Jolla Alcohol Research, Inc. and PI of the Small Business Innovation Research Grant R44 DA041967 supporting further commercialization of the inhalation equipment. All other authors declare no competing financial interests.

  • This work was supported by National Institutes of Health Grants F31-DA-053064 (to M.Z.), T32-NS-007431 (to M.Z.), P30-ES10126 (to C.R.E.), P01-HL-108808 (to C.R.E.), and P30-DK-065988 (to C.R.E.); The Scripps Research Institute Animal Models Core (A.J.R.); and National Institutes of Health Grants AA-026858 (to M.A.H.) and AA-011605 (to M.A.H.).

Funding

  • HHS | NIH | National Institute on Drug Abuse (NIDA)

    F31-DA-053064
  • HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS)

    T32-NS-007431
  • HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

    P30-DK-065988
  • HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI)

    P01-HL-108808
  • HHS | NIH | National Institute of Environmental Health Sciences (NIEHS)

    P30-ES10126
  • Scripps Research Institute (The Scripps Research Institute)

  • HHS | NIH | National Institute on Alcohol Abuse and Alcoholism (NIAAA)

    AA-026858; AA-011605

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  • previous version (July 28, 2021).

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Apr 2025518528
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Total 2025451071151
Total95368491356
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Electronic Nicotine Vapor Exposure Produces Differential Changes in Central Amygdala Neuronal Activity, Thermoregulation and Locomotor Behavior in Male Mice
M. Zhu, M. Echeveste Sanchez, E. A. Douglass, J. V. Jahad, T. D. Hanback, T. N. Guhr Lee, C. R. Esther Jr., M. Cole, A. J. Roberts, M. A. Herman
eNeuro 28 July 2021, 8 (4) ENEURO.0189-21.2021; DOI: 10.1523/ENEURO.0189-21.2021

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Electronic Nicotine Vapor Exposure Produces Differential Changes in Central Amygdala Neuronal Activity, Thermoregulation and Locomotor Behavior in Male Mice
M. Zhu, M. Echeveste Sanchez, E. A. Douglass, J. V. Jahad, T. D. Hanback, T. N. Guhr Lee, C. R. Esther Jr., M. Cole, A. J. Roberts, M. A. Herman
eNeuro 28 July 2021, 8 (4) ENEURO.0189-21.2021; DOI: 10.1523/ENEURO.0189-21.2021
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Keywords

  • central amygdala
  • locomotion
  • Neuronal Firing
  • Nicotine inhalation
  • thermoregulation
  • Vapor exposure

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