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Research ArticleResearch Article: New Research, Disorders of the Nervous System

SCD Inhibition Protects from α-Synuclein-Induced Neurotoxicity But Is Toxic to Early Neuron Cultures

Justin W. Nicholatos, Joost Groot, Shekhar Dhokai, David Tran, Lori Hrdlicka, Thomas M. Carlile, Melissa Bennion, Isin Dalkilic-Liddle, Warren D. Hirst and Andreas Weihofen
eNeuro 22 July 2021, 8 (4) ENEURO.0166-21.2021; https://doi.org/10.1523/ENEURO.0166-21.2021
Justin W. Nicholatos
1Neurodegeneration Research Unit, Biogen, Cambridge, MA 02142
2Biogen Postdoctoral Scientist Program, Biogen, Cambridge, MA 02142
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Joost Groot
3Translational Genome Sciences, Biogen, Cambridge, MA 02142
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Shekhar Dhokai
4Biologics Drug Discovery, Biogen, Cambridge, MA 02142
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David Tran
1Neurodegeneration Research Unit, Biogen, Cambridge, MA 02142
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Lori Hrdlicka
1Neurodegeneration Research Unit, Biogen, Cambridge, MA 02142
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Thomas M. Carlile
3Translational Genome Sciences, Biogen, Cambridge, MA 02142
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Melissa Bennion
5Bioassays and High-Throughput Screens, Biogen, Cambridge, MA 02142
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Isin Dalkilic-Liddle
4Biologics Drug Discovery, Biogen, Cambridge, MA 02142
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Warren D. Hirst
1Neurodegeneration Research Unit, Biogen, Cambridge, MA 02142
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Andreas Weihofen
1Neurodegeneration Research Unit, Biogen, Cambridge, MA 02142
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0166-21.2021
PubMed 
34301719
Published By 
Society for Neuroscience
History 
  • Received April 7, 2021
  • Revision received July 8, 2021
  • Accepted July 13, 2021
  • Published online July 22, 2021.
Copyright & Usage 
Copyright © 2021 Nicholatos et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Justin W. Nicholatos1,2,
  2. Joost Groot3,
  3. Shekhar Dhokai4,
  4. David Tran1,
  5. Lori Hrdlicka1,
  6. Thomas M. Carlile3,
  7. Melissa Bennion5,
  8. Isin Dalkilic-Liddle4,
  9. Warren D. Hirst1 and
  10. Andreas Weihofen1
  1. 1Neurodegeneration Research Unit, Biogen, Cambridge, MA 02142
  2. 2Biogen Postdoctoral Scientist Program, Biogen, Cambridge, MA 02142
  3. 3Translational Genome Sciences, Biogen, Cambridge, MA 02142
  4. 4Biologics Drug Discovery, Biogen, Cambridge, MA 02142
  5. 5Bioassays and High-Throughput Screens, Biogen, Cambridge, MA 02142
  1. Correspondence should be addressed to Andreas Weihofen at andreas.weihofen{at}biogen.com.
  • J. Groot’s present address: Inzen Therapeutics, Cambridge, MA, 02139. L. Hrdlicka’s present address: AbbVie, Cambridge Research Center, Cambridge, MA, 02139.

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Author contributions

  1. Author contributions: A.W., W.D.H., and J.W.N. designed research; A.W., J.W.N., D.T., L.H., T.M.C., S.D., M.B., I.D.-L., and J.G. performed research; M.B. contributed unpublished reagents/analytic tools; A.W., J.W.N., and J.G. analyzed data; A.W. and J.W.N. wrote the paper.

  • J. Groot’s present address: Inzen Therapeutics, Cambridge, MA, 02139. L. Hrdlicka’s present address: AbbVie, Cambridge Research Center, Cambridge, MA, 02139.

Disclosures

  • All authors are current or former employees of Biogen Inc.

Other Version

  • You are viewing the most recent version of this article.
  • previous version (July 22, 2021).

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Article usage: July 2021 to March 2026

AbstractFullPdf
Jul 20213170154
Aug 2021319600181
Sep 20214263571
Oct 20211830055
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Dec 2021916456
Total 20217161922586
Jan 20221416349
Feb 2022412140
Mar 2022613729
Apr 202229725
May 2022421222
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Jul 202216816
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Jan 202336020
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May 202327020
Jun 202309118
Jul 2023710017
Aug 202329628
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Total 2023411126238
Jan 20241211423
Feb 202448917
Mar 2024710328
Apr 2024510725
May 2024611025
Jun 202489623
Jul 2024711525
Aug 202478822
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Dec 2024493100
Total 2024831218343
Jan 2025610719
Feb 2025213029
Mar 2025513025
Apr 2025511117
May 202559527
Jun 20251011325
Jul 20251411833
Aug 20251111334
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Oct 20251413324
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Dec 20252014634
Total 20251151490314
Jan 20261515938
Feb 20261423427
Mar 202649416
Total 20263348781
Total104576281892
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SCD Inhibition Protects from α-Synuclein-Induced Neurotoxicity But Is Toxic to Early Neuron Cultures
Justin W. Nicholatos, Joost Groot, Shekhar Dhokai, David Tran, Lori Hrdlicka, Thomas M. Carlile, Melissa Bennion, Isin Dalkilic-Liddle, Warren D. Hirst, Andreas Weihofen
eNeuro 22 July 2021, 8 (4) ENEURO.0166-21.2021; DOI: 10.1523/ENEURO.0166-21.2021

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SCD Inhibition Protects from α-Synuclein-Induced Neurotoxicity But Is Toxic to Early Neuron Cultures
Justin W. Nicholatos, Joost Groot, Shekhar Dhokai, David Tran, Lori Hrdlicka, Thomas M. Carlile, Melissa Bennion, Isin Dalkilic-Liddle, Warren D. Hirst, Andreas Weihofen
eNeuro 22 July 2021, 8 (4) ENEURO.0166-21.2021; DOI: 10.1523/ENEURO.0166-21.2021
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Keywords

  • cell-based assays
  • lipids
  • neurotoxicity
  • Parkinson’s disease
  • SCD
  • synuclein

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