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Research ArticleResearch Article: New Research, Cognition and Behavior

Maternal Oxycodone Treatment Results in Neurobehavioral Disruptions in Mice Offspring

Rachel E. Martin, Madison T. Green, Jessica A. Kinkade, Robert R. Schmidt, Tess E. Willemse, A. Katrin Schenk, Jiude Mao and Cheryl S. Rosenfeld
eNeuro 26 July 2021, 8 (4) ENEURO.0150-21.2021; https://doi.org/10.1523/ENEURO.0150-21.2021
Rachel E. Martin
1Christopher S Bond Life Sciences Center, University of Missouri, Columbia, MO 65211
2Biomedical Sciences, University of Missouri, Columbia, MO 65211
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Madison T. Green
1Christopher S Bond Life Sciences Center, University of Missouri, Columbia, MO 65211
2Biomedical Sciences, University of Missouri, Columbia, MO 65211
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Jessica A. Kinkade
1Christopher S Bond Life Sciences Center, University of Missouri, Columbia, MO 65211
2Biomedical Sciences, University of Missouri, Columbia, MO 65211
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Robert R. Schmidt
1Christopher S Bond Life Sciences Center, University of Missouri, Columbia, MO 65211
2Biomedical Sciences, University of Missouri, Columbia, MO 65211
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Tess E. Willemse
1Christopher S Bond Life Sciences Center, University of Missouri, Columbia, MO 65211
2Biomedical Sciences, University of Missouri, Columbia, MO 65211
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A. Katrin Schenk
3Physics, Randolph College, Lynchburg, VA 24503
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Jiude Mao
1Christopher S Bond Life Sciences Center, University of Missouri, Columbia, MO 65211
2Biomedical Sciences, University of Missouri, Columbia, MO 65211
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Cheryl S. Rosenfeld
1Christopher S Bond Life Sciences Center, University of Missouri, Columbia, MO 65211
2Biomedical Sciences, University of Missouri, Columbia, MO 65211
4MU Institute for Data Science and Informatics, University of Missouri, Columbia, MO 65211
5Thompson Center for Autism and Neurobehavioral Disorders, University of Missouri, Columbia, MO 65211
6Genetics Area Program, University of Missouri, Columbia, MO 65211
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0150-21.2021
PubMed 
34312305
Published By 
Society for Neuroscience
History 
  • Received April 6, 2021
  • Revision received June 28, 2021
  • Accepted July 6, 2021
  • Published online July 26, 2021.
Copyright & Usage 
Copyright © 2021 Martin et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Rachel E. Martin1,2,
  2. Madison T. Green1,2,
  3. Jessica A. Kinkade1,2,
  4. Robert R. Schmidt1,2,
  5. Tess E. Willemse1,2,
  6. A. Katrin Schenk3,
  7. Jiude Mao1,2 and
  8. Cheryl S. Rosenfeld1,2,4,5,6
  1. 1Christopher S Bond Life Sciences Center, University of Missouri, Columbia, MO 65211
  2. 2Biomedical Sciences, University of Missouri, Columbia, MO 65211
  3. 3Physics, Randolph College, Lynchburg, VA 24503
  4. 4MU Institute for Data Science and Informatics, University of Missouri, Columbia, MO 65211
  5. 5Thompson Center for Autism and Neurobehavioral Disorders, University of Missouri, Columbia, MO 65211
  6. 6Genetics Area Program, University of Missouri, Columbia, MO 65211
  1. Correspondence should be addressed to Cheryl S. Rosenfeld at rosenfeldc{at}missouri.edu.
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Author contributions

  1. Author contributions: R.E.M., M.T.G., J.A.K., R.R.S., T.E.W., and J.M. performed research; A.K.S. and J.M. analyzed data; C.S.R., R.E.M., M.T.G., A.K.S., and J.M. designed research; C.S.R., R.E.M., M.T.G., J.A.K., R.R.S., A.K.S., and J.M. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by the National Institute of Environmental Health Sciences Grant 1R01ES025547 (to C.S.R.).

Funding

  • HHS | NIH | National Institute of Environmental Health Sciences (NIEHS)

    1R01ES025547

Other Version

  • You are viewing the most recent version of this article.
  • previous version (July 26, 2021).

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Jul 2021360073
Aug 2021427532168
Sep 202141538100
Oct 20212623654
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Total 20218801541482
Jan 20221412639
Feb 202297841
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Apr 202246923
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Jun 2022210529
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May 202338615
Jun 202306911
Jul 202378217
Aug 202336917
Sep 202349515
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Total 202361978199
Jan 2024179119
Feb 2024129622
Mar 202459818
Apr 2024239124
May 202479820
Jun 202478112
Jul 202478520
Aug 202478718
Sep 202489232
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Total 20241101069218
Jan 2025148819
Feb 202588733
Mar 2025410012
Apr 2025109020
May 202535412
Total 20253941996
Total120950111316
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eneuro: 8 (4)
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Maternal Oxycodone Treatment Results in Neurobehavioral Disruptions in Mice Offspring
Rachel E. Martin, Madison T. Green, Jessica A. Kinkade, Robert R. Schmidt, Tess E. Willemse, A. Katrin Schenk, Jiude Mao, Cheryl S. Rosenfeld
eNeuro 26 July 2021, 8 (4) ENEURO.0150-21.2021; DOI: 10.1523/ENEURO.0150-21.2021

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Maternal Oxycodone Treatment Results in Neurobehavioral Disruptions in Mice Offspring
Rachel E. Martin, Madison T. Green, Jessica A. Kinkade, Robert R. Schmidt, Tess E. Willemse, A. Katrin Schenk, Jiude Mao, Cheryl S. Rosenfeld
eNeuro 26 July 2021, 8 (4) ENEURO.0150-21.2021; DOI: 10.1523/ENEURO.0150-21.2021
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Keywords

  • Analgesic
  • brain
  • DOHaD
  • drug abuse
  • gene expression
  • opioid

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