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Research ArticleResearch Article: New Research, Cognition and Behavior

Effects of Withdrawal from Cocaine Self-Administration on Rat Orbitofrontal Cortex Parvalbumin Neurons Expressing Cre recombinase: Sex-Dependent Changes in Neuronal Function and Unaltered Serotonin Signaling

Andrew M. Wright, Agustin Zapata, Alexander F. Hoffman, Julie C. Necarsulmer, Lamarque M. Coke, Reinis Svarcbahs, Christopher T. Richie, James Pickel, Bruce T. Hope, Brandon K. Harvey and Carl R. Lupica
eNeuro 3 June 2021, 8 (4) ENEURO.0017-21.2021; https://doi.org/10.1523/ENEURO.0017-21.2021
Andrew M. Wright
1Electrophysiology Research Section, Cellular Neurobiology Branch with: Cellular and Neurocomputational Systems Branch
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Agustin Zapata
1Electrophysiology Research Section, Cellular Neurobiology Branch with: Cellular and Neurocomputational Systems Branch
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Alexander F. Hoffman
1Electrophysiology Research Section, Cellular Neurobiology Branch with: Cellular and Neurocomputational Systems Branch
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  • ORCID record for Alexander F. Hoffman
Julie C. Necarsulmer
2Molecular Mechanisms of Cellular Stress and Inflammation Section
3Optogenetics and Transgenic Technology Core
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  • ORCID record for Julie C. Necarsulmer
Lamarque M. Coke
2Molecular Mechanisms of Cellular Stress and Inflammation Section
3Optogenetics and Transgenic Technology Core
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Reinis Svarcbahs
2Molecular Mechanisms of Cellular Stress and Inflammation Section
3Optogenetics and Transgenic Technology Core
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Christopher T. Richie
3Optogenetics and Transgenic Technology Core
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James Pickel
5Transgenic Technology Core, Intramural Research Program, National Institute of Mental Health, Bethesda, MD 20892
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Bruce T. Hope
4Neuronal Ensembles in Drug Addiction Section Integrative Neuroscience Branch, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore, MD 21224
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Brandon K. Harvey
2Molecular Mechanisms of Cellular Stress and Inflammation Section
3Optogenetics and Transgenic Technology Core
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Carl R. Lupica
1Electrophysiology Research Section, Cellular Neurobiology Branch with: Cellular and Neurocomputational Systems Branch
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  • ORCID record for Carl R. Lupica
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0017-21.2021
PubMed 
34083381
Published By 
Society for Neuroscience
History 
  • Received January 9, 2021
  • Revision received May 14, 2021
  • Accepted May 20, 2021
  • Published online June 3, 2021.
Copyright & Usage 
Copyright © 2021 Wright et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Andrew M. Wright1,
  2. Agustin Zapata1,
  3. Alexander F. Hoffman1,
  4. Julie C. Necarsulmer2,3,
  5. Lamarque M. Coke2,3,
  6. Reinis Svarcbahs2,3,
  7. Christopher T. Richie3,
  8. James Pickel5,
  9. Bruce T. Hope4,
  10. Brandon K. Harvey2,3 and
  11. Carl R. Lupica1
  1. 1Electrophysiology Research Section, Cellular Neurobiology Branch with: Cellular and Neurocomputational Systems Branch
  2. 2Molecular Mechanisms of Cellular Stress and Inflammation Section
  3. 3Optogenetics and Transgenic Technology Core
  4. 4Neuronal Ensembles in Drug Addiction Section Integrative Neuroscience Branch, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore, MD 21224
  5. 5Transgenic Technology Core, Intramural Research Program, National Institute of Mental Health, Bethesda, MD 20892
  1. Correspondence should be addressed to Carl R. Lupica at clupica{at}nih.gov.
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Author contributions

  1. Author contributions: A.M.W., A.Z., C.T.R., J.P., B.T.H., B.K.H., and C.R.L. designed research; A.M.W., A.Z., A.F.H., J.C.N., L.M.C., R.S., and C.T.R. performed research; C.T.R., J.P., B.T.H., and B.K.H. contributed unpublished reagents/analytic tools; A.M.W., A.Z., A.F.H., J.C.N., L.M.C., R.S., C.T.R., B.T.H., B.K.H., and C.R.L. analyzed data; A.M.W., A.F.H., C.T.R., B.T.H., B.K.H., and C.R.L. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • This work supported by the National Institutes of Health, National Institute on Drug Abuse Intramural Research Program (IRP), and National Institute of Mental Health IRP.

Funding

  • HHS | NIH | National Institute on Drug Abuse (NIDA)

    1ZIADA000599
  • HHS | NIH | National Institute of Mental Health (NIMH)

Other Version

  • You are viewing the most recent version of this article.
  • previous version (June 03, 2021).

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Jun 20214210208
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Aug 20214858286
Sep 20211732266
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Jul 202238151
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May 20241510731
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Aug 20241010051
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Total 20251071317347
Jan 20261220628
Feb 20261223990
Mar 2026221039
Total 202646548127
Total119774622017
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Effects of Withdrawal from Cocaine Self-Administration on Rat Orbitofrontal Cortex Parvalbumin Neurons Expressing Cre recombinase: Sex-Dependent Changes in Neuronal Function and Unaltered Serotonin Signaling
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Effects of Withdrawal from Cocaine Self-Administration on Rat Orbitofrontal Cortex Parvalbumin Neurons Expressing Cre recombinase: Sex-Dependent Changes in Neuronal Function and Unaltered Serotonin Signaling
Andrew M. Wright, Agustin Zapata, Alexander F. Hoffman, Julie C. Necarsulmer, Lamarque M. Coke, Reinis Svarcbahs, Christopher T. Richie, James Pickel, Bruce T. Hope, Brandon K. Harvey, Carl R. Lupica
eNeuro 3 June 2021, 8 (4) ENEURO.0017-21.2021; DOI: 10.1523/ENEURO.0017-21.2021

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Effects of Withdrawal from Cocaine Self-Administration on Rat Orbitofrontal Cortex Parvalbumin Neurons Expressing Cre recombinase: Sex-Dependent Changes in Neuronal Function and Unaltered Serotonin Signaling
Andrew M. Wright, Agustin Zapata, Alexander F. Hoffman, Julie C. Necarsulmer, Lamarque M. Coke, Reinis Svarcbahs, Christopher T. Richie, James Pickel, Bruce T. Hope, Brandon K. Harvey, Carl R. Lupica
eNeuro 3 June 2021, 8 (4) ENEURO.0017-21.2021; DOI: 10.1523/ENEURO.0017-21.2021
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Keywords

  • addiction
  • electrophysiology
  • orbitofrontal cortex
  • parvalbumin
  • self-administration
  • serotonin

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