Skip to main content

Main menu

  • HOME
  • CONTENT
    • Early Release
    • Featured
    • Current Issue
    • Issue Archive
    • Blog
    • Collections
    • Podcast
  • TOPICS
    • Cognition and Behavior
    • Development
    • Disorders of the Nervous System
    • History, Teaching and Public Awareness
    • Integrative Systems
    • Neuronal Excitability
    • Novel Tools and Methods
    • Sensory and Motor Systems
  • ALERTS
  • FOR AUTHORS
  • ABOUT
    • Overview
    • Editorial Board
    • For the Media
    • Privacy Policy
    • Contact Us
    • Feedback
  • SUBMIT

User menu

Search

  • Advanced search
eNeuro
eNeuro

Advanced Search

 

  • HOME
  • CONTENT
    • Early Release
    • Featured
    • Current Issue
    • Issue Archive
    • Blog
    • Collections
    • Podcast
  • TOPICS
    • Cognition and Behavior
    • Development
    • Disorders of the Nervous System
    • History, Teaching and Public Awareness
    • Integrative Systems
    • Neuronal Excitability
    • Novel Tools and Methods
    • Sensory and Motor Systems
  • ALERTS
  • FOR AUTHORS
  • ABOUT
    • Overview
    • Editorial Board
    • For the Media
    • Privacy Policy
    • Contact Us
    • Feedback
  • SUBMIT
PreviousNext
Research ArticleResearch Article: New Research, Development

Astrocyte-Derived Thrombospondin Induces Cortical Synaptogenesis in a Sex-Specific Manner

Anna Mazur, Ean H. Bills, Kayla M. DeSchepper, James C. Williamson, Brandon J. Henderson and W. Christopher Risher
eNeuro 15 July 2021, 8 (4) ENEURO.0014-21.2021; https://doi.org/10.1523/ENEURO.0014-21.2021
Anna Mazur
Department of Biomedical Sciences, Joan C. Edwards School of Medicine at Marshall University, Huntington, WV 25701
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ean H. Bills
Department of Biomedical Sciences, Joan C. Edwards School of Medicine at Marshall University, Huntington, WV 25701
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Kayla M. DeSchepper
Department of Biomedical Sciences, Joan C. Edwards School of Medicine at Marshall University, Huntington, WV 25701
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
James C. Williamson
Department of Biomedical Sciences, Joan C. Edwards School of Medicine at Marshall University, Huntington, WV 25701
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Brandon J. Henderson
Department of Biomedical Sciences, Joan C. Edwards School of Medicine at Marshall University, Huntington, WV 25701
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Brandon J. Henderson
W. Christopher Risher
Department of Biomedical Sciences, Joan C. Edwards School of Medicine at Marshall University, Huntington, WV 25701
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for W. Christopher Risher
  • Article
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF
Loading

Article Information

DOI 
https://doi.org/10.1523/ENEURO.0014-21.2021
PubMed 
34266964
Published By 
Society for Neuroscience
History 
  • Received January 12, 2021
  • Revision received June 22, 2021
  • Accepted July 3, 2021
  • Published online July 15, 2021.
Copyright & Usage 
Copyright © 2021 Mazur et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Anna Mazur,
  2. Ean H. Bills,
  3. Kayla M. DeSchepper,
  4. James C. Williamson,
  5. Brandon J. Henderson and
  6. W. Christopher Risher
  1. Department of Biomedical Sciences, Joan C. Edwards School of Medicine at Marshall University, Huntington, WV 25701
  1. Correspondence should be addressed to W. Christopher Risher at risherw{at}marshall.edu.
View Full Text

Author contributions

  1. Author contributions: W.C.R. designed research; A.M., E.H.B., K.M.D., J.C.W., B.J.H., and W.C.R. performed research; A.M., B.J.H., and W.C.R. analyzed data; A.M. and W.C.R. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by the National Institutes of Health Grant 1R15MH126345-01 (to W.C.R.), Marshall University startup funds (B.J.H. and W.C.R.), the Marshall University Undergraduate Creative Discovery and Research Scholar Award (E.H.B.), the Marshall University Genomics and Bioinformatics Core, the West Virginia IDeA Network of Biomedical Research Excellence (WV-INBRE) Grant P20GM103434, the COBRE ACCORD Grant 1P20GM121299, and the West Virginia Clinical and Translational Science Institute (WV-CTSI) Grant 2U54GM104942.

Funding

  • Marshall University

  • HHS | NIH | National Institute of General Medical Sciences (NIGMS)

    P20GM103434; 1P20GM121299; 2U54GM104942
  • HHS | NIH | National Institute of Mental Health (NIMH)

    1R15MH126345-01

Other Version

  • You are viewing the most recent version of this article.
  • previous version (July 15, 2021).

Online Impact

 

Article usage

Select a custom date range for the past year
E.g., 2026-04-13
to
E.g., 2026-04-13

Article usage: July 2021 to April 2026

AbstractFullPdf
Jul 2021135456315
Aug 2021287547109
Sep 20213725941
Oct 20212130944
Nov 20211219430
Dec 20211116346
Total 202117221528585
Jan 20221415627
Feb 2022129830
Mar 2022816332
Apr 202228925
May 2022613720
Jun 2022410413
Jul 2022410624
Aug 202238325
Sep 202246426
Oct 202239319
Nov 2022109125
Dec 202226114
Total 2022721245280
Jan 202319217
Feb 202328513
Mar 202329717
Apr 20232858
May 2023210125
Jun 202319314
Jul 2023712424
Aug 2023310936
Sep 2023311015
Oct 2023510213
Nov 20231012428
Dec 20231013431
Total 2023481256241
Jan 20241310011
Feb 202489720
Mar 2024910515
Apr 20241833628
May 2024512827
Jun 2024410822
Jul 202479317
Aug 2024710539
Sep 2024610518
Oct 2024511424
Nov 2024110718
Dec 2024711316
Total 2024901511255
Jan 20251312128
Feb 2025810525
Mar 2025109513
Apr 2025411522
May 2025111917
Jun 2025610612
Jul 20251011633
Aug 2025911320
Sep 2025914228
Oct 2025920135
Nov 20251518514
Dec 2025719431
Total 20251011612278
Jan 20262731037
Feb 20261720927
Mar 20261122671
Apr 2026265620
Total 202681801155
Total211479531794
Back to top

In this issue

eneuro: 8 (4)
eNeuro
Vol. 8, Issue 4
July/August 2021
  • Table of Contents
  • Index by author
  • Ed Board (PDF)
Email

Thank you for sharing this eNeuro article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Astrocyte-Derived Thrombospondin Induces Cortical Synaptogenesis in a Sex-Specific Manner
(Your Name) has forwarded a page to you from eNeuro
(Your Name) thought you would be interested in this article in eNeuro.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Print
View Full Page PDF
Citation Tools
Astrocyte-Derived Thrombospondin Induces Cortical Synaptogenesis in a Sex-Specific Manner
Anna Mazur, Ean H. Bills, Kayla M. DeSchepper, James C. Williamson, Brandon J. Henderson, W. Christopher Risher
eNeuro 15 July 2021, 8 (4) ENEURO.0014-21.2021; DOI: 10.1523/ENEURO.0014-21.2021

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Respond to this article
Share
Astrocyte-Derived Thrombospondin Induces Cortical Synaptogenesis in a Sex-Specific Manner
Anna Mazur, Ean H. Bills, Kayla M. DeSchepper, James C. Williamson, Brandon J. Henderson, W. Christopher Risher
eNeuro 15 July 2021, 8 (4) ENEURO.0014-21.2021; DOI: 10.1523/ENEURO.0014-21.2021
Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Significance Statement
    • Introduction
    • Materials and Methods
    • Results
    • Discussion
    • Acknowledgments
    • Footnotes
    • References
    • Synthesis
    • Author Response
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF

Keywords

  • astrocytes
  • cortex
  • estrogen
  • sex differences
  • synaptogenesis
  • thrombospondin

Responses to this article

Respond to this article

Jump to comment:

No eLetters have been published for this article.

Related Articles

Cited By...

More in this TOC Section

Research Article: New Research

  • Environmental Enrichment Attenuates Fentanyl-Seeking Behavior and Protects Against Stress-Induced Reinstatement in Both Male and Female Rats
  • Microglial morphological complexity in the piriform cortex is associated with olfactory aversion following chronic stress
  • Dopamine and calcium dynamics in the nucleus accumbens core during food seeking
Show more Research Article: New Research

Development

  • Astrocyte-derived PTPRZ1 regulates excitatory synapse density in the mouse cortex
  • sAPPα Inhibits Neurite Outgrowth in Primary Mouse Neurons via GABA B Receptor Subunit 1a
  • Partial Deletion of Cxcl12 from Hippocampal Cajal–Retzius Cells Does Not Disrupt Dentate Gyrus Development or Neurobehaviors
Show more Development

Subjects

  • Development
  • Home
  • Alerts
  • Follow SFN on BlueSky
  • Visit Society for Neuroscience on Facebook
  • Follow Society for Neuroscience on Twitter
  • Follow Society for Neuroscience on LinkedIn
  • Visit Society for Neuroscience on Youtube
  • Follow our RSS feeds

Content

  • Early Release
  • Current Issue
  • Latest Articles
  • Issue Archive
  • Blog
  • Browse by Topic

Information

  • For Authors
  • For the Media

About

  • About the Journal
  • Editorial Board
  • Privacy Notice
  • Contact
  • Feedback
(eNeuro logo)
(SfN logo)

Copyright © 2026 by the Society for Neuroscience.
eNeuro eISSN: 2373-2822

The ideas and opinions expressed in eNeuro do not necessarily reflect those of SfN or the eNeuro Editorial Board. Publication of an advertisement or other product mention in eNeuro should not be construed as an endorsement of the manufacturer’s claims. SfN does not assume any responsibility for any injury and/or damage to persons or property arising from or related to any use of any material contained in eNeuro.