Skip to main content

Main menu

  • HOME
  • CONTENT
    • Early Release
    • Featured
    • Current Issue
    • Issue Archive
    • Blog
    • Collections
    • Podcast
  • TOPICS
    • Cognition and Behavior
    • Development
    • Disorders of the Nervous System
    • History, Teaching and Public Awareness
    • Integrative Systems
    • Neuronal Excitability
    • Novel Tools and Methods
    • Sensory and Motor Systems
  • ALERTS
  • FOR AUTHORS
  • ABOUT
    • Overview
    • Editorial Board
    • For the Media
    • Privacy Policy
    • Contact Us
    • Feedback
  • SUBMIT

User menu

Search

  • Advanced search
eNeuro
eNeuro

Advanced Search

 

  • HOME
  • CONTENT
    • Early Release
    • Featured
    • Current Issue
    • Issue Archive
    • Blog
    • Collections
    • Podcast
  • TOPICS
    • Cognition and Behavior
    • Development
    • Disorders of the Nervous System
    • History, Teaching and Public Awareness
    • Integrative Systems
    • Neuronal Excitability
    • Novel Tools and Methods
    • Sensory and Motor Systems
  • ALERTS
  • FOR AUTHORS
  • ABOUT
    • Overview
    • Editorial Board
    • For the Media
    • Privacy Policy
    • Contact Us
    • Feedback
  • SUBMIT
PreviousNext
Research ArticleResearch Article: New Research, Development

Increased RET Activity Coupled with a Reduction in the RET Gene Dosage Causes Intestinal Aganglionosis in Mice

Mitsumasa Okamoto, Toshihiro Uesaka, Keisuke Ito and Hideki Enomoto
eNeuro 6 May 2021, 8 (3) ENEURO.0534-20.2021; https://doi.org/10.1523/ENEURO.0534-20.2021
Mitsumasa Okamoto
Division for Neural Differentiation and Regeneration, Department of Physiology and Cell Biology, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Toshihiro Uesaka
Division for Neural Differentiation and Regeneration, Department of Physiology and Cell Biology, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Keisuke Ito
Division for Neural Differentiation and Regeneration, Department of Physiology and Cell Biology, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Hideki Enomoto
Division for Neural Differentiation and Regeneration, Department of Physiology and Cell Biology, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Hideki Enomoto
  • Article
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF
Loading

Article Information

DOI 
https://doi.org/10.1523/ENEURO.0534-20.2021
PubMed 
33958373
Published By 
Society for Neuroscience
History 
  • Received December 8, 2020
  • Revision received March 24, 2021
  • Accepted April 13, 2021
  • Published online May 6, 2021.
Copyright & Usage 
Copyright © 2021 Okamoto et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Mitsumasa Okamoto,
  2. Toshihiro Uesaka,
  3. Keisuke Ito and
  4. Hideki Enomoto
  1. Division for Neural Differentiation and Regeneration, Department of Physiology and Cell Biology, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan
  1. Correspondence should be addressed to Hideki Enomoto at enomotoh{at}med.kobe-u.ac.jp.
View Full Text

Author contributions

  1. Author contributions: T.U. and H.E. designed research; M.O., T.U., and K.I. performed research; M.O., T.U., K.I., and H.E. analyzed data; H.E. contributed unpublished reagents/analytic tools; H.E. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by Japan Society for the Promotion of Science, Japan, Grants 17H03550, 17K19527, and 16K08466; Grant-in-Aid for Scientific Research on Innovative Areas “Stem Cell Aging and Disease” 25115002 from MEXT; the Takeda Science Foundation; and the Yakult Bio-Science Foundation.

Funding

  • Japan Society for the Promotion of Science (JSPS)

    17H03550; 17K19527; 16K08466
  • Grants-in-Aid for Scientific Research on Innovative Areas

    #25115002
  • Takeda Science Foundation

  • Yakult Bio-Science Foundation

Other Version

  • You are viewing the most recent version of this article.
  • previous version (May 06, 2021).

Online Impact

 

Article usage

Select a custom date range for the past year
E.g., 2026-06-08
to
E.g., 2026-06-08

Article usage: May 2021 to April 2026

AbstractFullPdf
May 20212840113
Jun 202147236959
Jul 20216222423
Aug 20213118714
Sep 20211616722
Oct 20211316732
Nov 20218104105
Dec 2021410122
Total 20218901319390
Jan 202299414
Feb 202264310
Mar 202235612
Apr 2022427014
May 202218632
Jun 20225837
Jul 202255612
Aug 202224913
Sep 202225511
Oct 2022346124
Nov 2022422216
Dec 20221368
Total 2022451511173
Jan 20232438
Feb 20230607
Mar 20233745
Apr 20234798
May 20231554
Jun 20230718
Jul 202327218
Aug 202327721
Sep 202337513
Oct 20236806
Nov 20230774
Dec 2023510027
Total 202328863129
Jan 20240727
Feb 202407315
Mar 202418014
Apr 202478011
May 202428222
Jun 202448319
Jul 202437615
Aug 202437415
Sep 202467120
Oct 20243788
Nov 202427715
Dec 202448011
Total 202435926172
Jan 202579620
Feb 20253855
Mar 202518014
Apr 202538214
May 20250774
Jun 202514799
Jul 20251311725
Aug 202539227
Sep 2025912322
Oct 20251211021
Nov 20251713844
Dec 20251412548
Total 2025961204253
Jan 20261712927
Feb 20261518520
Mar 20261217334
Apr 20261322349
Total 202657710130
Total115165331247
Back to top

In this issue

eneuro: 8 (3)
eNeuro
Vol. 8, Issue 3
May/June 2021
  • Table of Contents
  • Index by author
  • Ed Board (PDF)
Email

Thank you for sharing this eNeuro article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Increased RET Activity Coupled with a Reduction in the RET Gene Dosage Causes Intestinal Aganglionosis in Mice
(Your Name) has forwarded a page to you from eNeuro
(Your Name) thought you would be interested in this article in eNeuro.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Print
View Full Page PDF
Citation Tools
Increased RET Activity Coupled with a Reduction in the RET Gene Dosage Causes Intestinal Aganglionosis in Mice
Mitsumasa Okamoto, Toshihiro Uesaka, Keisuke Ito, Hideki Enomoto
eNeuro 6 May 2021, 8 (3) ENEURO.0534-20.2021; DOI: 10.1523/ENEURO.0534-20.2021

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Respond to this article
Share
Increased RET Activity Coupled with a Reduction in the RET Gene Dosage Causes Intestinal Aganglionosis in Mice
Mitsumasa Okamoto, Toshihiro Uesaka, Keisuke Ito, Hideki Enomoto
eNeuro 6 May 2021, 8 (3) ENEURO.0534-20.2021; DOI: 10.1523/ENEURO.0534-20.2021
Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Significance Statement
    • Introduction
    • Materials and Methods
    • Results
    • Discussion
    • Acknowledgments
    • Footnotes
    • References
    • Synthesis
    • Author Response
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF

Keywords

  • cell signaling
  • enteric nervous system
  • Hirschsprung’s disease
  • neuronal differentiation
  • RET

Responses to this article

Respond to this article

Jump to comment:

No eLetters have been published for this article.

Related Articles

Cited By...

More in this TOC Section

Research Article: New Research

  • Disrupting motor cortical regional activity during motor sequence skill training impairs human motor visuomotor skill acquisition and learning that is not sequence-specific
  • Whole-Brain Mapping of Neuronal Activity Associated with Vocal Socialization Behaviors in Adult Mice
  • Effect of Functionally Selective Dopamine D1 Receptor Agonists on Complex Cognitive Processes in a Rodent Touchscreen Operant Chamber Task
Show more Research Article: New Research

Development

  • The Interaction between Sleep and Development on Wake EEG Oscillations
  • Astrocyte-Derived PTPRZ1 Regulates Excitatory Synapse Density in the Mouse Cortex
  • sAPPα Inhibits Neurite Outgrowth in Primary Mouse Neurons via GABA B Receptor Subunit 1a
Show more Development

Subjects

  • Development
  • Home
  • Alerts
  • Follow SFN on BlueSky
  • Visit Society for Neuroscience on Facebook
  • Follow Society for Neuroscience on Twitter
  • Follow Society for Neuroscience on LinkedIn
  • Visit Society for Neuroscience on Youtube
  • Follow our RSS feeds

Content

  • Early Release
  • Current Issue
  • Latest Articles
  • Issue Archive
  • Blog
  • Browse by Topic

Information

  • For Authors
  • For the Media

About

  • About the Journal
  • Editorial Board
  • Privacy Notice
  • Contact
  • Feedback
(eNeuro logo)
(SfN logo)

Copyright © 2026 by the Society for Neuroscience.
eNeuro eISSN: 2373-2822

The ideas and opinions expressed in eNeuro do not necessarily reflect those of SfN or the eNeuro Editorial Board. Publication of an advertisement or other product mention in eNeuro should not be construed as an endorsement of the manufacturer’s claims. SfN does not assume any responsibility for any injury and/or damage to persons or property arising from or related to any use of any material contained in eNeuro.