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Research ArticleResearch Article: Negative Results, Disorders of the Nervous System

No Detectable Effect on Visual Responses Using Functional MRI in a Rodent Model of α-Synuclein Expression

Freja Gam Østergaard, Christian Stald Skoven, Alex R. Wade, Hartwig R. Siebner, Bettina Laursen, Kenneth Vielsted Christensen and Tim B. Dyrby
eNeuro 6 May 2021, 8 (3) ENEURO.0516-20.2021; https://doi.org/10.1523/ENEURO.0516-20.2021
Freja Gam Østergaard
1Circuit Biology, H. Lundbeck A/S, Valby DK-2500, Denmark
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Christian Stald Skoven
3Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital - Amager and Hvidovre, Copenhagen 2650, Denmark
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Alex R. Wade
2Department of Psychology, The University of York, Heslington, York YO10 5DD, United Kingdom
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Hartwig R. Siebner
3Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital - Amager and Hvidovre, Copenhagen 2650, Denmark
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Bettina Laursen
1Circuit Biology, H. Lundbeck A/S, Valby DK-2500, Denmark
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Kenneth Vielsted Christensen
1Circuit Biology, H. Lundbeck A/S, Valby DK-2500, Denmark
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Tim B. Dyrby
3Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital - Amager and Hvidovre, Copenhagen 2650, Denmark
4Department of Applied Mathematics and Computer Science, Technical University of Denmark, Kongens Lyngby 2800, Denmark
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0516-20.2021
PubMed 
33958374
Published By 
Society for Neuroscience
History 
  • Received November 30, 2020
  • Revision received April 23, 2021
  • Accepted April 30, 2021
  • Published online May 6, 2021.
Copyright & Usage 
Copyright © 2021 Østergaard et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Freja Gam Østergaard1,
  2. Christian Stald Skoven3,
  3. Alex R. Wade2,
  4. Hartwig R. Siebner3,
  5. Bettina Laursen1,
  6. Kenneth Vielsted Christensen1 and
  7. Tim B. Dyrby3,4
  1. 1Circuit Biology, H. Lundbeck A/S, Valby DK-2500, Denmark
  2. 2Department of Psychology, The University of York, Heslington, York YO10 5DD, United Kingdom
  3. 3Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital - Amager and Hvidovre, Copenhagen 2650, Denmark
  4. 4Department of Applied Mathematics and Computer Science, Technical University of Denmark, Kongens Lyngby 2800, Denmark
  1. Correspondence should be addressed to Freja Gam Østergaard at f.g.ostergaard{at}rug.nl
View Full Text

Author contributions

  1. Author contributions: F.G.Ø. and K.V.C. designed research; F.G.Ø. and C.S.S. performed research; F.G.Ø. and A.R.W. analyzed data; F.G.Ø., C.S.S., A.R.W., H.R.S., B.L., K.V.C., and T.B.D. wrote the paper.

Disclosures

  • H.R.S. has received honoraria as speaker from Sanofi Genzyme, Denmark and Novartis, Denmark, as consultant from Lundbeck AS, Denmark and Sanofi Genzyme, Denmark, and as senior editor (NeuroImage) and Editor-in-Chief (Neurimage-Clinical) from Elsevier Publishers, Amsterdam, The Netherlands. He has also received royalties as book editor from Springer Publishers, Stuttgart, Germany, and Gyldendal, Copenhagen, Denmark. All other authors declare no competing financial interests.

  • This work was supported by the European Union’s Horizon 2020 Research and Innovation Programme under the Marie Sklodowska-Curie Grant 641805. H.R.S. holds a five-year professorship in precision medicine at the Faculty of Health Sciences and Medicine, University of Copenhagen, which is sponsored by the Lundbeck Foundation Grant R186-2015-2138.

Funding

  • EC | Horizon 2020 (EU Framework Programme for Research and Innovation)

    641805
  • Lundbeckfonden (Lundbeck Foundation)

    R186-2015-2138

Other Version

  • You are viewing the most recent version of this article.
  • previous version (May 06, 2021).

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Total 2025881150185
Jan 20261712515
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Total 20261822317
Total163853921069
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eneuro: 8 (3)
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May/June 2021
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No Detectable Effect on Visual Responses Using Functional MRI in a Rodent Model of α-Synuclein Expression
Freja Gam Østergaard, Christian Stald Skoven, Alex R. Wade, Hartwig R. Siebner, Bettina Laursen, Kenneth Vielsted Christensen, Tim B. Dyrby
eNeuro 6 May 2021, 8 (3) ENEURO.0516-20.2021; DOI: 10.1523/ENEURO.0516-20.2021

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No Detectable Effect on Visual Responses Using Functional MRI in a Rodent Model of α-Synuclein Expression
Freja Gam Østergaard, Christian Stald Skoven, Alex R. Wade, Hartwig R. Siebner, Bettina Laursen, Kenneth Vielsted Christensen, Tim B. Dyrby
eNeuro 6 May 2021, 8 (3) ENEURO.0516-20.2021; DOI: 10.1523/ENEURO.0516-20.2021
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Keywords

  • α-synuclein
  • fMRI
  • rat
  • superior colliculus
  • vision

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