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Research ArticleResearch Article: New Research, Cognition and Behavior

Fast Periodic Auditory Stimulation Reveals a Robust Categorical Response to Voices in the Human Brain

Francesca M. Barbero, Roberta P. Calce, Siddharth Talwar, Bruno Rossion and Olivier Collignon
eNeuro 20 May 2021, 8 (3) ENEURO.0471-20.2021; DOI: https://doi.org/10.1523/ENEURO.0471-20.2021
Francesca M. Barbero
1Institute of Research in Psychology and Institute of Neuroscience, Louvain Bionics Center, University of Louvain, Louvain-la-Neuve 1348, Belgium
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Roberta P. Calce
1Institute of Research in Psychology and Institute of Neuroscience, Louvain Bionics Center, University of Louvain, Louvain-la-Neuve 1348, Belgium
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Siddharth Talwar
1Institute of Research in Psychology and Institute of Neuroscience, Louvain Bionics Center, University of Louvain, Louvain-la-Neuve 1348, Belgium
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Bruno Rossion
1Institute of Research in Psychology and Institute of Neuroscience, Louvain Bionics Center, University of Louvain, Louvain-la-Neuve 1348, Belgium
2Université de Lorraine, Centre National de la Recherche Scientifique, Centre de Recherche en Automatique de Nancy, Nancy F-54000, France
3Université de Lorraine, Service de Neurologie, Centre Hospitalier Régional et Universitaire-Nancy F-54000, France
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Olivier Collignon
1Institute of Research in Psychology and Institute of Neuroscience, Louvain Bionics Center, University of Louvain, Louvain-la-Neuve 1348, Belgium
4Center for Mind/Brain Sciences, University of Trento, Rovereto 38068, Italy
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    Figure 1.

    Experimental design for experiments 1 (A–C) and 2 (D, E). A, Three seconds excerpts of the sequences for the standard (top) and scrambled (bottom) sequences (left) with their relative spectrograms (right). B, Schematic representation of the paradigm. C, Standard and scrambled sequences: Bode magnitude plot expressing the magnitude in decibels as a function of frequency for the averaged sounds of vocal and non-vocal stimuli separately, for standard and scrambled sequences. D, Three seconds excerpts of the harmonic sequence (left) with its spectrogram (right). E, Acoustic features as a function of sound category: HNR, pitch, and spectral center of gravity.

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    Figure 2.

    Experiment 1. Voice versus object sounds. A, Responses at the base (top) and at the target frequency (bottom) for the standard (left) and scrambled (right) conditions as topographic head plots. Topographic head plots were obtained by summing the baseline subtracted amplitude at the significant harmonics. B, Source localization analysis revealed stronger coherence values at the target frequency for the standard condition (standard > scrambled) over right superior and middle temporal areas (voxels with intensity above the 95th percentile are highlighted in red). C, Signal-to-noise ratio (SNR) of voice-selective responses obtained by averaging SNR values of ROIvoice electrodes as a function of number of stimulation sequences/minutes of recording for the standard condition. D, SNR averaged spectra of ROIvoice electrodes. E, Sum of the baseline corrected amplitude (considering 10 bins on each side, excluding the immediately adjacent ones) of voice selective responses at the four significant harmonics for the standard (blue) and scrambled condition (orange). F, Responses at the target frequency for the standard (blue) and scrambled (orange) conditions as the sum of baseline subtracted amplitude at four harmonics in the left and right ROIs. G, There is no correlation between responses at the left and right ROIs across the standard and scrambled conditions.

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    Figure 3.

    Experiment 1. Responses at the voice presentation frequency for each individual (standard condition). Topographic head plots represent the sum of the baseline subtracted amplitude of significant harmonics as identified at the group level. The scale of each head plot ranges from 0 μV to the maximum (reported on top) for each subject.

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    Figure 4.

    Experiment 2. Voice versus musical instruments. A, Responses at the base and at the target frequency as topographic head plots. Topographic head plots were obtained by summing the baseline subtracted amplitude at the significant harmonics. B, SNR averaged spectra of ROIvoice electrodes.

  • Figure 5.
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    Figure 5.

    Experiment 3. Behavioral detection of voices. Sensitivity indices for the sequence (left) and isolation (right) tasks, for the three conditions. The bar plots represent the group average of d′, each dot represents an individual participant’s d′ score.

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Fast Periodic Auditory Stimulation Reveals a Robust Categorical Response to Voices in the Human Brain
Francesca M. Barbero, Roberta P. Calce, Siddharth Talwar, Bruno Rossion, Olivier Collignon
eNeuro 20 May 2021, 8 (3) ENEURO.0471-20.2021; DOI: 10.1523/ENEURO.0471-20.2021

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Fast Periodic Auditory Stimulation Reveals a Robust Categorical Response to Voices in the Human Brain
Francesca M. Barbero, Roberta P. Calce, Siddharth Talwar, Bruno Rossion, Olivier Collignon
eNeuro 20 May 2021, 8 (3) ENEURO.0471-20.2021; DOI: 10.1523/ENEURO.0471-20.2021
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Keywords

  • auditory cortex
  • electroencephalography
  • frequency tagging
  • voice

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