Article Figures & Data
Figures
- Figure 1.
Patients having Parkinson’s disease with ongoing trimetazidine treatment (A), new initiations or withdrawal (B) from 2010 to 2016 and interrupted time series models. EMA, European Medicines Agency; PD, Parkinson’s disease; TMZ, trimetazidine.
- Figure 2.
Possible indications for ongoing TMZ treatment (A) and new initiations on the drug (B) in PD from 2010 to 2016. The following categorizations were used: (1) antianginal indication (ICD-10-CM I20, on-label prescriptions); (2) other cardiological indications (ICD-10-CM I00-I99 with the exemption of ICD-10-CM I20, possibly off-label prescriptions after the EMA warning); (3) ophthalmological indications (ICD-10-CM H30-H36, definitely off-label prescriptions after the EMA warning); and (4) otological indications (ICD-10-CM H80-H83, definitely off-label indications after the EMA warning). Other non-investigated disorders might have also served as the basis of TMZ use or initiation. One patient might have had more than one diagnosis. ICD-10-CM, International Classification of WHO Diseases, 10th Revision, Clinical Modification.
Tables
Estimate Standard error t value p value ARIMA model parameters 1 Outcomes No transformation Constant 3726.399 145.993 25.525 <0.001 AR Lag 1 0.609 0.446 1.364 0.206 Time period No transformation Numerator Lag 0 259.585 38.550 6.734 <0.001 Phase No transformation Numerator Lag 0 3144.925 305.505 10.294 <0.001 Interact No transformation Numerator Lag 0 −530.221 50.743 −10.449 <0.001 ARIMA model parameters 2 Outcomes No transformation Constant 3725.494 145.369 25.628 <0.001 AR Lag 1 0.605 0.447 1.352 0.209 Phase No transformation Numerator Lag 0 −37.185 133.227 −0.279 0.786 6 months preintervention No transformation Numerator Lag 0 259.901 38.473 6.755 <0.001 6 months postintervention No transformation Numerator Lag 0 −270.593 29.031 −9.321 <0.001 ARIMA model parameters 3 Outcomes No transformation Constant 3725.852 145.951 25.528 <0.001 AR Lag 1 0.609 0.446 1.364 0.206 Phase No transformation Numerator Lag 0 −567.264 151.953 −3.733 0.005 12 months preintervention No transformation Numerator Lag 0 259.802 38.542 6.741 <0.001 12 months postintervention No transformation Numerator Lag 0 −270.729 29.187 −9.276 <0.001 ARIMA model parameters 4 Outcomes No transformation Constant 3725.668 145.560 25.595 <0.001 AR Lag 1 0.606 0.447 1.356 0.208 Phase No transformation Numerator Lag 0 −1097.990 183.443 −5.985 <0.001 18 months preintervention No transformation Numerator Lag 0 259.844 38.496 6.750 <0.001 18 months postintervention No transformation Numerator Lag 0 −270.607 29.076 −9.307 <0.001 ARIMA model parameters 5 Outcomes No transformation Constant 3724.868 145.799 25.548 <0.001 AR Lag 1 0.608 0.447 1.362 0.206 Phase No transformation Numerator Lag 0 −1629.819 222.141 −7.337 <0.001 24 months preintervention No transformation Numerator Lag 0 260.098 38.526 6.751 <0.001 24 months postintervention No transformation Numerator Lag 0 −270.753 29.171 −9.282 <0.001 ARIMA model parameters 6 Outcomes No transformation Constant 3724.800 145.744 25.557 <0.001 AR Lag 1 0.608 0.447 1.362 0.206 Phase No transformation Numerator Lag 0 −2160.452 264.907 −8.156 <0.001 30 months preintervention No transformation Numerator Lag 0 260.093 38.520 6.752 <0.001 30 months postintervention No transformation Numerator Lag 0 −270.776 29.142 −9.291 <0.001 ARIMA model parameters 7 Outcomes No transformation Constant 3725.820 145.699 25.572 <0.001 AR Lag 1 0.607 0.447 1.359 0.207 Phase No transformation Numerator Lag 0 −2688.893 309.975 −8.675 <0.001 36 months preintervention No transformation Numerator Lag 0 259.782 38.514 6.745 <0.001 36 months postintervention No transformation Numerator Lag 0 −270.635 29.101 −9.300 <0.001 ARIMA model parameters 8 Outcomes No transformation Constant 3725.288 145.465 25.609 <0.001 AR Lag 1 0.606 0.447 1.354 0.209 Phase No transformation Numerator Lag 0 −3220.464 356.342 −9.038 <0.001 42 months preintervention No transformation Numerator Lag 0 259.944 38.486 6.754 <0.001 42 months postintervention No transformation Numerator Lag 0 −270.626 29.045 −9.317 <0.001 ARIMA model parameters 9 Outcomes No transformation Constant 3725.283 145.604 25.585 <0.001 AR Lag 1 0.607 0.447 1.357 0.208 Phase No transformation Numerator Lag 0 −3751.680 404.167 −9.282 <0.001 48 months preintervention No transformation Numerator Lag 0 259.969 38.501 6.752 <0.001 48 months postintervention No transformation Numerator Lag 0 −270.673 29.106 −9.300 <0.001 ARIMA model parameters 10 Outcomes No transformation Constant 3725.515 146.026 25.513 <0.001 AR Lag 1 0.610 0.446 1.368 0.205 Phase No transformation Numerator Lag 0 −4282.119 453.283 −9.447 <0.001 54 months preintervention No transformation Numerator Lag 0 259.869 38.551 6.741 <0.001 54 months postintervention No transformation Numerator Lag 0 −270.905 29.197 −9.279 <0.001 Estimate Standard error t value p value ARIMA model parameters 1 Outcomes No transformation Constant 82.121 47.138 1.742 0.115 AR Lag 1 −0.343 0.567 −0.605 0.560 Time period No transformation Numerator Lag 0 34.983 14.450 2.421 0.039 Phase No transformation Numerator Lag 0 327.730 75.612 4.334 0.002 Interact No transformation Numerator Lag 0 −49.690 15.668 −3.171 0.011 ARIMA model parameters 2 Outcomes No transformation Constant 82.142 47.147 1.742 0.115 AR Lag 1 −0.343 0.567 −0.605 0.560 Phase No transformation Numerator Lag 0 29.606 55.124 0.537 0.604 6 months preintervention No transformation Numerator Lag 0 34.977 14.453 2.420 0.039 6 months postintervention No transformation Numerator Lag 0 −14.705 6.041 −2.434 0.038 ARIMA model parameters 3 Outcomes No transformation Constant 82.141 47.146 1.742 0.115 AR Lag 1 −0.343 0.567 −0.605 0.560 Phase No transformation Numerator Lag 0 −20.078 65.658 −0.306 0.767 12 months preintervention No transformation Numerator Lag 0 34.977 14.452 2.420 0.039 12 months postintervention No transformation Numerator Lag 0 −14.706 6.041 −2.434 0.038 ARIMA model parameters 4 Outcomes No transformation Constant 82.139 47.146 1.742 0.115 AR Lag 1 −0.343 0.567 −0.605 0.560 Phase No transformation Numerator Lag 0 −69.764 77.938 −0.895 0.394 18 months preintervention No transformation Numerator Lag 0 34.978 14.452 2.420 0.039 18 months postintervention No transformation Numerator Lag 0 −14.706 6.041 −2.434 0.038 ARIMA model parameters 5 Outcomes No transformation Constant 82.137 47.145 1.742 0.115 AR Lag 1 −0.343 0.567 −0.605 0.560 Phase No transformation Numerator Lag 0 −119.451 91.262 −1.309 0.223 24 months preintervention No transformation Numerator Lag 0 34.979 14.452 2.420 0.039 24 months postintervention No transformation Numerator Lag 0 −14.706 6.041 −2.434 0.038 ARIMA model parameters 6 Outcomes No transformation Constant 82.134 47.144 1.742 0.115 AR Lag 1 −0.343 0.567 −0.605 0.560 Phase No transformation Numerator Lag 0 −169.141 105.233 −1.607 0.142 30 months preintervention No transformation Numerator Lag 0 34.979 14.452 2.420 0.039 30 months postintervention No transformation Numerator Lag 0 −14.706 6.041 −2.434 0.038 ARIMA model parameters 7 Outcomes No transformation Constant 82.131 47.142 1.742 0.115 AR Lag 1 −0.343 0.567 −0.605 0.560 Phase No transformation Numerator Lag 0 −218.834 119.624 −1.829 0.101 36 months preintervention No transformation Numerator Lag 0 34.980 14.451 2.421 0.039 36 months postintervention No transformation Numerator Lag 0 −14.706 6.041 −2.435 0.038 ARIMA model parameters 8 Outcomes No transformation Constant 82.128 47.141 1.742 0.115 AR Lag 1 −0.343 0.567 −0.605 0.560 Phase No transformation Numerator Lag 0 −268.529 134.300 −1.999 0.077 42 months preintervention No transformation Numerator Lag 0 34.981 14.451 2.421 0.039 42 months postintervention No transformation Numerator Lag 0 −14.706 6.040 −2.435 0.038 ARIMA model parameters 9 Outcomes No transformation Constant 82.125 47.140 1.742 0.115 AR Lag 1 −0.343 0.567 −0.605 0.560 Phase No transformation Numerator Lag 0 −318.228 149.176 −2.133 0.062 48 months preintervention No transformation Numerator Lag 0 34.982 14.450 2.421 0.039 48 months postintervention No transformation Numerator Lag 0 −14.707 6.040 −2.435 0.038 ARIMA model parameters 10 Outcomes No transformation Constant 82.121 47.139 1.742 0.115 AR Lag 1 −0.343 0.567 −0.605 0.560 Phase No transformation Numerator Lag 0 −367.929 164.198 −2.241 0.052 54 months preintervention No transformation Numerator Lag 0 34.983 14.450 2.421 0.039 54 months postintervention No transformation Numerator Lag 0 −14.707 6.040 −2.435 0.038 Estimate Standard error t value p value ARIMA model parameters 1 Outcomes No transformation Constant 776.317 103.231 7.520 <0.001 AR Lag 1 −0.297 0.326 −0.910 0.386 Time period No transformation Numerator Lag 0 −118.993 31.738 −3.749 0.005 Phase No transformation Numerator Lag 0 −396.802 155.769 −2.547 0.031 Interact No transformation Numerator Lag 0 105.419 32.868 3.207 0.011 ARIMA model parameters 2 Outcomes No transformation Constant 776.291 103.227 7.520 <0.001 AR Lag 1 −0.297 0.326 −0.911 0.386 Phase No transformation Numerator Lag 0 235.690 124.116 1.899 0.090 6 months preintervention No transformation Numerator Lag 0 −118.985 31.736 −3.749 0.005 6 months postintervention No transformation Numerator Lag 0 −13.573 12.070 −1.125 0.290 ARIMA model parameters 3 Outcomes No transformation Constant 776.294 103.228 70.520 <0.001 AR Lag 1 −0.297 0.326 −0.911 0.386 Phase No transformation Numerator Lag 0 341.105 146.596 2.327 0.045 12 months preintervention No transformation Numerator Lag 0 −118.986 31.736 −3.749 0.005 12 months postintervention No transformation Numerator Lag 0 −13.574 12.070 −1.125 0.290 ARIMA model parameters 4 Outcomes No transformation Constant 776.297 103.228 7.520 <0.001 AR Lag 1 −0.297 0.326 −0.911 0.386 Phase No transformation Numerator Lag 0 446.522 172.443 2.589 0.029 18 months preintervention No transformation Numerator Lag 0 −118.987 31.736 −3.749 0.005 18 months postintervention No transformation Numerator Lag 0 −13.574 12.070 −1.125 0.290 ARIMA model parameters 5 Outcomes No transformation Constant 776.301 103.229 7.520 <0.001 AR Lag 1 −0.297 0.326 −0.911 0.386 Phase No transformation Numerator Lag 0 551.942 200.359 2.755 0.022 24 months preintervention No transformation Numerator Lag 0 −118.988 31.737 −3.749 0.005 24 months postintervention No transformation Numerator Lag 0 −13.574 12.070 −1.125 0.290 ARIMA model parameters 6 Outcomes No transformation Constant 776.305 103.229 7.520 <0.001 AR Lag 1 −0.297 0.326 −0.911 0.386 Phase No transformation Numerator Lag 0 657.365 229.590 2.863 0.019 30 months preintervention No transformation Numerator Lag 0 −118.989 31.737 −3.749 0.005 30 months postintervention No transformation Numerator Lag 0 −13.574 12.070 −1.125 0.290 ARIMA model parameters 7 Outcomes No transformation Constant 776.310 103.230 7.520 <0.001 AR Lag 1 −0.297 0.326 −0.910 0.386 Phase No transformation Numerator Lag 0 762.790 259.693 2.937 0.017 36 months preintervention No transformation Numerator Lag 0 −118.991 31.737 −3.749 0.005 36 months postintervention No transformation Numerator Lag 0 −13.574 12.071 −1.125 0.290 ARIMA model parameters 8 Outcomes No transformation Constant 776.315 103.231 7.520 <0.001 AR Lag 1 −0.297 0.326 −0.910 0.386 Phase No transformation Numerator Lag 0 868.219 290.398 2.990 0.015 42 months preintervention No transformation Numerator Lag 0 −118.992 31.737 −3.749 0.005 42 months postintervention No transformation Numerator Lag 0 −13.574 12.071 −1.125 0.290 ARIMA model parameters 9 Outcomes No transformation Constant 776.320 103.232 7.520 <0.001 AR Lag 1 −0.297 0.326 −0.910 0.386 Phase No transformation Numerator Lag 0 973.651 321.531 3.028 0.014 48 months preintervention No transformation Numerator Lag 0 −118.994 31.738 −3.749 0.005 48 months postintervention No transformation Numerator Lag 0 −13.574 12.071 −1.125 0.290 ARIMA model parameters 10 Outcomes No transformation Constant 776.325 103.233 7.520 <0.001 AR Lag 1 −0.297 0.326 −0.910 0.386 Phase No transformation Numerator Lag 0 1079.087 352.980 3.057 0.014 54 months preintervention No transformation Numerator Lag 0 −118.995 31.738 −3.749 0.005 54 months postintervention No transformation Numerator Lag 0 −13.574 12.071 −1.125 0.290
In this issue
Trimetazidine Use in Parkinson’s Disease: Is It a Resolved Problem?
