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Research ArticleResearch Article: New Research, Neuronal Excitability

Altered Phosphorylation of the Proteasome Subunit Rpt6 Has Minimal Impact on Synaptic Plasticity and Learning

Samantha L. Scudder, Frankie R. Gonzales, Kristin K. Howell, Ivar S. Stein, Lara E. Dozier, Stephan G. Anagnostaras, Karen Zito and Gentry N. Patrick
eNeuro 3 March 2021, 8 (3) ENEURO.0073-20.2021; https://doi.org/10.1523/ENEURO.0073-20.2021
Samantha L. Scudder
1Section of Neurobiology, Division of Biological Sciences, University of California San Diego, La Jolla, CA 92093-0347
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Frankie R. Gonzales
1Section of Neurobiology, Division of Biological Sciences, University of California San Diego, La Jolla, CA 92093-0347
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Kristin K. Howell
2Molecular Cognition Laboratory, Department of Psychology, University of California San Diego, La Jolla, CA 92093-0109
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Ivar S. Stein
3Center for Neuroscience, University of California, Davis, CA 95618-4859
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Lara E. Dozier
1Section of Neurobiology, Division of Biological Sciences, University of California San Diego, La Jolla, CA 92093-0347
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Stephan G. Anagnostaras
2Molecular Cognition Laboratory, Department of Psychology, University of California San Diego, La Jolla, CA 92093-0109
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Karen Zito
3Center for Neuroscience, University of California, Davis, CA 95618-4859
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Gentry N. Patrick
1Section of Neurobiology, Division of Biological Sciences, University of California San Diego, La Jolla, CA 92093-0347
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0073-20.2021
PubMed 
33658307
Published By 
Society for Neuroscience
History 
  • Received February 25, 2020
  • Revision received January 13, 2021
  • Accepted January 27, 2021
  • Published online March 3, 2021.
Copyright & Usage 
Copyright © 2021 Scudder et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Samantha L. Scudder1,*,
  2. Frankie R. Gonzales1,*,
  3. Kristin K. Howell2,
  4. Ivar S. Stein3,
  5. Lara E. Dozier1,
  6. Stephan G. Anagnostaras2,
  7. Karen Zito3 and
  8. Gentry N. Patrick1
  1. 1Section of Neurobiology, Division of Biological Sciences, University of California San Diego, La Jolla, CA 92093-0347
  2. 2Molecular Cognition Laboratory, Department of Psychology, University of California San Diego, La Jolla, CA 92093-0109
  3. 3Center for Neuroscience, University of California, Davis, CA 95618-4859
  1. Correspondence should be addressed to Gentry N. Patrick at gpatrick{at}ucsd.edu.
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Author contributions

  1. Author contributions: S.L.S., F.R.G., K.K.H., I.S.S., L.E.D., S.G.A., K.Z., and G.N.P. designed research; S.L.S., F.R.G., K.K.H., I.S.S., L.E.D., S.G.A., K.Z., and G.N.P. performed research; S.L.S., F.R.G., K.K.H., I.S.S., L.E.D., S.G.A., K.Z., and G.N.P. analyzed data; S.L.S., F.R.G., and G.N.P. wrote the paper.

  2. ↵* S.L.S. and F.R.G. contributed equally to this work.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by National Science Foundation Graduate Research Fellowships (S.L.S. and K.K.H.) and National Institutes of Health Grants NS060847 (to G.N.P.), DA020041 (to S.G.A.), and NS062736 (to K.Z.).

Funding

  • NIH

    DA020041; NS062736; NS060847
  • NSF GRFP

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  • previous version (March 03, 2021).

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Altered Phosphorylation of the Proteasome Subunit Rpt6 Has Minimal Impact on Synaptic Plasticity and Learning
Samantha L. Scudder, Frankie R. Gonzales, Kristin K. Howell, Ivar S. Stein, Lara E. Dozier, Stephan G. Anagnostaras, Karen Zito, Gentry N. Patrick
eNeuro 3 March 2021, 8 (3) ENEURO.0073-20.2021; DOI: 10.1523/ENEURO.0073-20.2021

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Altered Phosphorylation of the Proteasome Subunit Rpt6 Has Minimal Impact on Synaptic Plasticity and Learning
Samantha L. Scudder, Frankie R. Gonzales, Kristin K. Howell, Ivar S. Stein, Lara E. Dozier, Stephan G. Anagnostaras, Karen Zito, Gentry N. Patrick
eNeuro 3 March 2021, 8 (3) ENEURO.0073-20.2021; DOI: 10.1523/ENEURO.0073-20.2021
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Keywords

  • degradation
  • dendritic spines
  • LTP
  • plasticity
  • proteasome
  • Rpt6

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