Article Figures & Data
Figures
- Figure 1.
Characterization of chronic sugar drinking, SDE, and locomotor activity in male and female GluN1DATCreERT2 mice. A, G, Baseline sugar intake in g/kg/d after free-choice access to a bottle containing a sugar solution (5% w/v) and a bottle with tap water in the homecage for eight weeks in wild-type male (n = 26), female (n = 25), and GluN1DATCreERT2 male (n = 25) and female (n = 24) mice. B, H, Baseline locomotor activity after eight weeks of free-choice sugar drinking. C, I, Diurnal drinking pattern during baseline sucrose consumption and during the SDE. D, J, Diurnal activity pattern during baseline sucrose consumption and during the SDE. E, K, Relapse behavior measured in % change from baseline during the first 4 h of the SDE. F, L, Relative change in locomotor activity during the first 4 h of the SDE in relation to baseline activity; * indicates significant changes (p < 0.001) in sucrose consumption or activity during the SDE when compared with baseline; # indicates significant (p < 0.05) genotype differences.
- Figure 2.
Characterization of chronic sugar drinking, SDE, and locomotor activity in male and female GluN1D1CreERT2 mice. A, G, Baseline sugar intake in g/kg/d after free-choice access to a bottle containing a sugar solution (5% w/v) solution and a bottle with tap water in the homecage for eight weeks in wild-type male (n = 19), female (n = 20), and GluN1D1CreERT2 male (n = 21) and female (n = 19) mice. B, H, Baseline locomotor activity after eight weeks of free-choice sugar drinking. C, I, Diurnal drinking pattern during baseline sucrose consumption and during the SDE. D, J, Diurnal activity pattern during baseline sucrose consumption and during the SDE. E, K, Relapse behavior measured in % change from baseline during the first 4 h of the SDE. F, L, Relative change in locomotor activity during the first 4 h of the SDE in relation to baseline activity; * indicates significant changes (p < 0.05) in sucrose consumption or activity during the SDE when compared with baseline; # indicates significant (p < 0.05 or p < 0.01 for A, G, L, K, respectively) genotype differences.
- Figure 3.
Characterization of chronic sugar drinking, SDE, and locomotor activity in male and female GluA1DATCreERT2 mice. A, G, Baseline sugar intake in g/kg/d after free-choice access to a bottle containing a sugar solution (5% w/v) solution and a bottle with tap water in the homecage for eight weeks in wild-type male (n = 26), female (n = 25), and GluA1DATCreERT2 male (n = 26) and female (n = 27) mice. B, H, Baseline locomotor activity after eight weeks of free-choice sugar drinking. C, I, Diurnal drinking pattern during baseline sucrose consumption and during the SDE. D, J, Diurnal activity pattern during baseline sucrose consumption and during the SDE. E, K, Relapse behavior measured in % change from baseline during the first 4 h of the SDE. F, L, Relative change in locomotor activity during the first 4 h of the SDE in relation to baseline activity; * indicates significant changes (p < 0.01) in sucrose consumption or activity during the SDE when compared with baseline.
- Figure 4.
Characterization of chronic sugar drinking, SDE, and locomotor activity in male and female GluA1D1CreERT2 mice. A, G, Baseline sugar intake in g/kg/d after free-choice access to a bottle containing a sugar solution (5% w/v) solution and a bottle with tap water in the homecage for eight weeks in wild-type male (n = 19), female (n = 20), and GluA1D1CreERT2 male (n = 18) and female (n = 20) mice. B, H, Baseline locomotor activity after eight weeks of free-choice sugar drinking. C, I, Diurnal drinking pattern during baseline sucrose consumption and during the SDE. D, J, Diurnal activity pattern during baseline sucrose consumption and during the SDE. E, K, Relapse behavior measured in % change from baseline during the first 4 h of the SDE. F, L, Relative change in locomotor activity during the first 4 h of the SDE in relation to baseline activity; * indicates significant changes (p < 0.05) in sucrose consumption or activity during the SDE when compared with baseline; # indicates significant (p < 0.05) genotype differences.
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