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Research ArticleResearch Article: New Research, Neuronal Excitability

Loss of KCNQ2 or KCNQ3 Leads to Multifocal Time-Varying Activity in the Neonatal Forebrain Ex Vivo

Bowen Hou, Nissi Varghese, Heun Soh, Sabato Santaniello and Anastasios V. Tzingounis
eNeuro 16 April 2021, 8 (3) ENEURO.0024-21.2021; https://doi.org/10.1523/ENEURO.0024-21.2021
Bowen Hou
1Department of Physiology and Neurobiology, University of Connecticut, Storrs, CT 06269
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Nissi Varghese
1Department of Physiology and Neurobiology, University of Connecticut, Storrs, CT 06269
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Heun Soh
1Department of Physiology and Neurobiology, University of Connecticut, Storrs, CT 06269
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Sabato Santaniello
2Department of Biomedical Engineering, University of Connecticut, Storrs, CT 06269
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Anastasios V. Tzingounis
1Department of Physiology and Neurobiology, University of Connecticut, Storrs, CT 06269
2Department of Biomedical Engineering, University of Connecticut, Storrs, CT 06269
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0024-21.2021
PubMed 
33863780
Published By 
Society for Neuroscience
History 
  • Received January 19, 2021
  • Revision received April 5, 2021
  • Accepted April 8, 2021
  • Published online April 16, 2021.
Copyright & Usage 
Copyright © 2021 Hou et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Bowen Hou1,
  2. Nissi Varghese1,
  3. Heun Soh1,
  4. Sabato Santaniello2 and
  5. Anastasios V. Tzingounis1,2
  1. 1Department of Physiology and Neurobiology, University of Connecticut, Storrs, CT 06269
  2. 2Department of Biomedical Engineering, University of Connecticut, Storrs, CT 06269
  1. Correspondence should be addressed to Anastasios V. Tzingounis at anastasios.tzingounis{at}uconn.edu or Sabato Santaniello at sabato.santaniello{at}uconn.edu.
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Author contributions

  1. Author contributions: B.H., S.S., and A.V.T. designed research; B.H., N.V., and H.S. performed research; B.H., S.S., and A.V.T. analyzed data; S.S. and A.V.T. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by National Institutes of Health Grants R01 NS101596, HL137094, NS108874 (to A.V.T.) and the National Science Foundation CAREER Award 1845348 (to S.S).

Funding

  • HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS)

    NS101596; NS108874
  • HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI)

    HL137094
  • NSF | ENG | Division of Electrical, Communications and Cyber Systems (ECCS)

    1845348

Other Version

  • You are viewing the most recent version of this article.
  • previous version (April 16, 2021).

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Article usage: April 2021 to December 2025

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Apr 20213250167
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Jun 20216026843
Jul 20212820828
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Jul 20251210320
Aug 2025108617
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Oct 2025910417
Nov 20251512415
Dec 20251176
Total 2025771091177
Total88451101206
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eneuro: 8 (3)
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May/June 2021
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Loss of KCNQ2 or KCNQ3 Leads to Multifocal Time-Varying Activity in the Neonatal Forebrain Ex Vivo
Bowen Hou, Nissi Varghese, Heun Soh, Sabato Santaniello, Anastasios V. Tzingounis
eNeuro 16 April 2021, 8 (3) ENEURO.0024-21.2021; DOI: 10.1523/ENEURO.0024-21.2021

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Loss of KCNQ2 or KCNQ3 Leads to Multifocal Time-Varying Activity in the Neonatal Forebrain Ex Vivo
Bowen Hou, Nissi Varghese, Heun Soh, Sabato Santaniello, Anastasios V. Tzingounis
eNeuro 16 April 2021, 8 (3) ENEURO.0024-21.2021; DOI: 10.1523/ENEURO.0024-21.2021
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Keywords

  • channelopathy
  • epilepsy
  • KCNQ2
  • KCNQ3
  • neurodevelopmental disorders
  • neurology

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