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Review, Cognition and Behavior

The Role of the Lateral Habenula in Inhibitory Learning from Reward Omission

Rodrigo Sosa, Jesús Mata-Luévanos and Mario Buenrostro-Jáuregui
eNeuro 7 May 2021, 8 (3) ENEURO.0016-21.2021; https://doi.org/10.1523/ENEURO.0016-21.2021
Rodrigo Sosa
1Universidad Panamericana, Escuela de Pedagogía, 49 Álvaro del Portillo, Ciudad Granja, Zapopan, 45010, Mexico
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Jesús Mata-Luévanos
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Mario Buenrostro-Jáuregui
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0016-21.2021
PubMed 
33962969
Published By 
Society for Neuroscience
History 
  • Received January 12, 2021
  • Revision received March 26, 2021
  • Accepted March 30, 2021
  • Published online May 7, 2021.
Copyright & Usage 
Copyright © 2021 Sosa et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Rodrigo Sosa,
  2. Jesús Mata-Luévanos and
  3. Mario Buenrostro-Jáuregui
  1. 1Universidad Panamericana, Escuela de Pedagogía, 49 Álvaro del Portillo, Ciudad Granja, Zapopan, 45010, Mexico
  2. 2Universidad Iberoamericana, Laboratorio de Neurociencias, 880 Prolongación Paseo de la Reforma, Lomas de Santa Fé, Mexico City, 01219, Mexico
  1. Correspondence should be addressed to Rodrigo Sosa at rsosas{at}up.edu.mx or Mario Buenrostro-Jáuregui at mario.buenrostro{at}ibero.mx.
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Author contributions

  1. Author contributions: R.S., conceived the idea and outlined the paper; R.S., J.M.-L., and M.B.-J. wrote the paper to equal extent; R.S. and M.B.-J. worked out the figures; J.M.-L. formatted the manuscript.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by the Sistema Nacional de Investigadores (SNI) grant for RS and MB-J, and by the Consejo Nacional de Ciencia y Tecnología (CONACyT) postdoctoral fellowship grant for J.M.-L.

  • ↵1 Note that the minimal response to the target stimulus observed after extinction procedures is quite labile and responding is often susceptible to bounce back after a slight contextual change (Bouton et al., 2021), this is not accounted by the Rescorla–Wagner model.

  • ↵2 This paradigm is more broadly known as Pavlovian conditioned inhibition; however, “conditioned inhibition” is also used to designate the process that the target stimulus undergoes (here termed “inhibitory learning”), as well as the empiric demonstration that such a process has taken place (Savastano et al. 1999); therefore, here we use the term “feature-negative discrimination” for the procedure and “inhibitory learning” for the process to avoid ambiguity.

Funding

  • Consejo Nacional de Ciencia y Tecnología (CONACYT)

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  • You are viewing the most recent version of this article.
  • previous version (May 07, 2021).

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AbstractFullPdf
May 20214230181
Jun 2021280128145
Jul 20217744786
Aug 20215331343
Sep 20212022836
Oct 20211920951
Nov 20213520976
Dec 20211921461
Total 20219261748679
Jan 20222123942
Feb 20221218354
Mar 2022720565
Apr 2022515928
May 2022523840
Jun 2022218031
Jul 2022413629
Aug 2022413432
Sep 202237633
Oct 20221011856
Nov 202269737
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Total 2022831831473
Jan 2023312536
Feb 2023110518
Mar 2023710920
Apr 2023310927
May 202329827
Jun 2023011422
Jul 2023910934
Aug 202379842
Sep 2023149833
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Dec 2023812928
Total 2023741358377
Jan 20245012522
Feb 20242112133
Mar 20241512538
Apr 20242014044
May 20241011723
Jun 20242011422
Jul 20241012934
Aug 2024159335
Sep 20241810930
Oct 20241510232
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Total 20242211413365
Jan 202599732
Feb 202579018
Mar 20251311943
Apr 20251713944
May 20253312824
Jun 20252012518
Jul 20251212122
Aug 20251011335
Sep 20253121139
Oct 20251413844
Nov 20252317327
Dec 20252418950
Total 20252131643396
Jan 20261112926
Total 20261112926
Total152881222316
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eneuro: 8 (3)
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May/June 2021
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The Role of the Lateral Habenula in Inhibitory Learning from Reward Omission
Rodrigo Sosa, Jesús Mata-Luévanos, Mario Buenrostro-Jáuregui
eNeuro 7 May 2021, 8 (3) ENEURO.0016-21.2021; DOI: 10.1523/ENEURO.0016-21.2021

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The Role of the Lateral Habenula in Inhibitory Learning from Reward Omission
Rodrigo Sosa, Jesús Mata-Luévanos, Mario Buenrostro-Jáuregui
eNeuro 7 May 2021, 8 (3) ENEURO.0016-21.2021; DOI: 10.1523/ENEURO.0016-21.2021
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  • Article
    • Abstract
    • Significance Statement
    • Introduction
    • Modeling the Dynamics of Acquisition and Extinction of Responding in Reward Learning
    • Inducing, Testing, and Modeling Net Inhibitory Effects
    • Dopamine Dips Propagate from Reward Omission to Events That Predict It
    • Concurrent Reward Cues Contribute to Dopamine Dips and Their Propagation
    • The LHb Promotes Stimulus-Specific and Response-Specific Inhibitory Effects
    • The LHb Participates in Inhibitory Learning Even without Temporally Specific Reward Omission
    • The Habenulo-Meso-Cortical Excitatory Pathway May Play a Role in Negative Reward Prediction Error
    • Relevance of the LHb for Mental Health
    • Directions for Moving the Field Forward
    • Summary and Concluding Remarks
    • Acknowledgments
    • Footnotes
    • References
    • Synthesis
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF

Keywords

  • dopamine signaling
  • conditioned inhibition
  • inhibitory control
  • mesolimbic pathway
  • mesocortical pathway
  • negative reward prediction error

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